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This study aimed to identify predictors and estimate time to teduglutide response among adult patients with short bowel syndrome with intestinal failure (SBS-IF) dependent on parenteral support (PS).

Post-hoc analysis was performed on individual patient data from teduglutide-treated patients in the phase III teduglutide trial STEPS and the STEPS-2 extension. Response was defined as ≥20% PS volume reduction from baseline for two consecutive visits. Early responders experienced the reduction at 20 and 24 weeks during STEPS while late responders experienced the reduction during STEPS-2. Timing and predictors for response were assessed among the treated population using Cox proportional hazard model. Time to response was compared in aetiological subgroups using Kaplan-Meier analysis. Patient characteristics and time to response were compared between early vs. late responders.

A total of 34 patients were included in this analysis; overall median time to response was 4.3 months. The presence of stoma predicteime to response to teduglutide depends on bowel anatomy and SBS-IF aetiology. IBD, presence of a stoma, and absence of ileocecal valve were associated with earlier response to teduglutide. (E/Z)-BCI mw These findings may enhance management of patients with SBS-IF; however, due to sample size limitations, additional studies are needed to confirm these findings.
Time to response to teduglutide depends on bowel anatomy and SBS-IF aetiology. IBD, presence of a stoma, and absence of ileocecal valve were associated with earlier response to teduglutide. These findings may enhance management of patients with SBS-IF; however, due to sample size limitations, additional studies are needed to confirm these findings.
Simple hyperosmolar dehydration, also termed water-loss dehydration (HD), is common in older hospitalised patients, thus increasing the risk of morbidity and mortality. Directly measured serum osmolality is the reference standard to determine HD; however, it is not a routine test due to its complexity and cost. Thus, a simple valid objective diagnostic tool to detect HD is needed. Consequently, we aimed to validate the agreement between measured s-osmolality (mOsm/kg) and calculated s-osmolarity (mOsm/L).

Patients aged >65 were included from the emergency medical department at Herlev Hospital, Copenhagen, Denmark. Exclusion criteria were eGFR< 30mmol/L, severe heart failure, decompensated cirrhosis, alcohol intake or initiated rehydration treatment. We obtained data for measured s-osmolality as well as calculated osmolarity, using the by ESPEN recommended equation [1.86x (Na
+K
)+1.15 ∗glucose+urea+14]. To determine accuracy, we used cut-off values of >295 mOsm/L versus >300 mOsm/kg.

A totpitalised medical patients. The method is markedly superior to the current clinical practice.
Survivors of critical illness experience significant skeletal muscle wasting that may predict clinical outcome. Ultrasound (US) is a noninvasive method that can measure muscle quadriceps muscle layer thickness (QMLT) at the bedside. The aim of this study was to determine the muscle loss assessed by ultrasonography (US) of the quadriceps femoris muscle in critically ill patients on mechanical ventilation and its relationship with hospital outcomes.

This study involved patients ≥18 years admitted to the intensive care unit who needed mechanical ventilation for at least 48h. The quadriceps muscle layer thickness (QMLT) in the two-thirds of the thigh was quantified using bedside US. The QMLT of the left and right legs on the first (D1), third (D3), and seventh (D7) days were measured.

US quadriceps thickness measurements were performed in 74 critically ill patients. The mean age was 62.3±19.5 years, 54.1% of the patients were men, with a BMI of 25.5±4.6kg/m2, SAPS 3 of 55.2±17.2, and NRS of 3.2±1.0. The perkness was associated with worse outcomes.
This study aims to describe the prevalence of overweight and obesity in an obesogenic environment among adolescents in the wilaya of Bejaia (eastern Algeria), and to assess their Physical Activity Level (PAL), Daily Energy Expenditure (DEE) and Total Energy Intake (TEI).

A cross-sectional study was carried out on a sample of 3038 adolescents consisting of 1635 girls and 1403 boys in middle and high schools in 19 regions of Bejaia. The average age was 14.78±2.53. Two questionnaires were assigned to collect data on their nutritional habits (24-h dietary call) and physical activity levels. BMI measurement was adopted in this study to determine the weight status of this sample and to assess the distribution of BMI, PAL, DEE, TEI over geographical areas of an administrative territory using the Student test descriptive statistical method (p<0.05).

The prevalence of obesity and overweight was equal to 3.3%, the physical activity level in adolescents was 1.72±0.21, with boys more likely to participate in sposed risk of obesity in adolescents.
RBP4, Vaspin and omentin-1 are adipokines, which play an important role in the development of obesity-related complications. The main aim of this study was to investigate the effects of different kinds of fat intake on adipokine levels in obese women.

A total of 272 obese women (BMI≥30) were included in the current cross-sectional study, according to the inclusion and exclusion criteria. Body composition was measured using a body composition analyzer. For the measurement of retinol binding protein 4 (RBP4), vaspin and omentin-1 serum concentrations, an enzyme-linked immunosorbent assay (ELISA) method was used. Dietary intake was assessed using a 3-day 24-h dietary recall.

Statistically significant differences were found between polyunsaturated fatty acid (PUFAs) and linoleic acid intake and vaspin and omentin-1 levels. In addition, there were found statistically significant relationships between cholesterol, monounsaturated fatty acid (MUFAs) and total fat intakes with omentin-1 levels. Also, RBP4 and vaspin levels were different significant with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake. Moreover, the results revealed that there were statistically significant differences between RBP4 levels and α-linolenic acid and oleic acid intake.

This study revealed that by examining RBP4, vaspin and omentin-1 as adipokines, a novel link between fat intakes and adipokine levels was found.
This study revealed that by examining RBP4, vaspin and omentin-1 as adipokines, a novel link between fat intakes and adipokine levels was found.
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