Notes

Modification of a knock-in computer mouse button label of acrodysostosis using gene therapy utilizing a rAAV9-CAG-human PRKAR1A vector.
Chemohyperthermia (CHT) with mitomycin C (MMC) is together with Bacillus Calmette-Guérin (BCG), and passive MMC, a treatment option for patients with non muscle-invasive bladder cancer. There are no data published about the impact of CHT in quality of life (QoL). We evaluated QoL and adverse events (AE) in this 3-arm observational study.

Prospective observational study from September 2016 to March 2017, we recruited consecutive patients that received adjuvant treatment after transurethral resection of bladder tumor. Patients received induction courses of either BCG, CHT, or passive MMC. Patients filled the questionnaires Functional assessment of cancer therapy for bladder cancer patients (FACT-Bl) and International prostate symptom score (IPSS) before, during, and after the induction course. A urologist documented AE using Common Terminology Criteria for AE (CTCAE criteria).

A total of 56 patients, receiving a total of 296 bladder instillations (BCG n = 27, CHT n = 14 and MMC n = 15). FACT-Bl showed staen compared with BCG.
There is considerable debate regarding the function of anterolateral knee structures, including the anterolateral ligament (ALL) and anterolateral capsule, as knee stabilizers in anterior cruciate ligament (ACL) injured knees. Medial meniscus posterior horn (MMPH) injuries have also been associated with increased knee laxity in ACL injured knees. The purpose of this cadaveric biomechanical study was to compare the effects of the anterolateral complex (ALC) injury and meniscectomy of MMPH on knee laxity in ACL injured knees.

ALC injury would have a greater effect on internal rotational laxity in ACL-injured knee than meniscectomy of MMPH.

Matched-pair 10 fresh-frozen cadaveric knees underwent biomechanical evaluation of knee laxity. After testing the intact knee and ACL sectioned knee (ACL-) in matched-pair 10 fresh-frozen cadaveric knees, two groups were established an ALC sectioning (ACL-/ALC-) group (n=5) and a MMPH meniscectomy (ACL-/MMPH-) group (n=5). Knee laxity was measured in terms of internal-ehile the MMPH may contribute to resisting external rotation and anterior translation stability in ACL-injured knee.

II, controlled laboratory study.
II, controlled laboratory study.
A tibial tubercle osteotomy (TTO) is a commonly performed procedure in young and active patients with patellofemoral complaints. Previous small patient series demonstrated a relatively high risk of complications, which appear to be technique dependent. The purpose of this large case series is to quantify the risk of procedure specific postoperative complications related to a uniform self-centering TTO technique in a large cohort, performed by two different surgeons in one center.

We hypothesize that non-union or fracture occurs in less than 1% of the procedures.

Five hundred and twenty-nine knees in four hundred and forty-seven patients who underwent a self-centering TTO with at least one year of follow-up were included. We performed a retrospective cohort review. Tibial fracture, osteotomy non-union, neurovascular complications, infection and wound complications that required surgical intervention were defined as major complications, miscellaneous complications were defined minor.

The major finding in this study is the low incidence of non-union (0.6%) and tibial fracture (0.4%). In total 9 (1.7%) major complications were reported. Minor complications included superficial wound infection in five patients, two patients had a venous thrombo-embolism (VTE).

A self-centering TTO is a relatively safe technique with a low number of non-union and fracture.

Level IV, retrospective cohort study.
Level IV, retrospective cohort study.
Addition of collagen during medial meniscal root repair (MMRR) may improve meniscal root healing minimising fibrous scar tissue formation. The purpose of this study was to verify the effect of atelocollagen on MMRR using the modified Mason-Allen stitch when compared with that of the conventional pullout repair by assessing the clinical and radiological outcomes.

It was hypothesised that atelocollagen would enhance the healing effect on the meniscal root following MMRR. Moreover, we presumed that MMRR with atelocollagen application might reduce meniscal extrusion by promoting healing.

A total of 47 patients who underwent MMRR using the modified Mason-Allen stitch between 2015 and 2016 were included, and they were divided into group A (atelocollagen application; n=25) and group R (MMRR without atelocollagen application; n=22). The postoperative clinical outcomes, radiological outcomes, and meniscal root healing and medial compartment cartilage status on follow-up magnetic resonance imaging (MRI) were comp±0.3mm following MMRR without significant differences (p=0.056 and p=0.229, respectively). The IMSI presented significant negative correlations with the root healing status and significant positive correlations with K-L grade progression (p<0.05).

Atelocollagen application during MMRR yielded lower IMSIs, suggesting better healing, than did conventional pullout root repair. https://www.selleckchem.com/products/CP-690550.html However, this technique could not demonstrate beneficial effects on meniscal extrusion.

III, retrospective case-control study.
III, retrospective case-control study.
Onset of spinal bone metastasis is a turning point in the progression of tumoral disease; although incidence is increasing, management is not standardized. Various prognostic scores are available, but advances in medical and surgical treatment have made them less well adapted, and sometimes discordant for a given patient. It would therefore be useful to develop new prognostic instruments. The aim of the present study was to identify biologic risk factors for onset of postoperative complications and death following spinal bone metastasis surgery.

A prospective multicenter study included all patients operated on for spinal bone metastasis between November 2015 and May 2017. The main epidemiologic data and biologic data (CRP, albuminemia, calcemia) were collected preoperatively. Surgical strategy, death and/or postoperative complications were collected prospectively.

Five of the initial 264 patients died during the immediate postoperative course, and 107 within 6 months. At 1 year, 57 patients remained alive.
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