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Specialist as well as carer meaningful worries when tending to youngsters that tube-feed.
Oral health is perhaps the most neglected aspect of healthcare for persons living in rehabilitation centers, compared to the general population. The caregivers play a vital role in administering daily oral care to residents in rehabilitation centers The aim of the present questionnaire-based study was to evaluate the caregivers' knowledge, attitude and practices towards oral healthcare at centers for the intellectually disabled in the Southern region of Saudi Arabia (SA). The present study was designed as a cross-sectional one-point time survey. The samples were selected by using a non-probability convenience sampling method. The self-administered closed-ended questionnaire comprised of 22 items divided into four sections, which was designed to elicit the demographic information, awareness of oral care, attitude towards oral health and practice of the oral healthcare regime among the participants. Of the164 participants, 53.0% and 47.0% were male and female, respectively. Most of the participants-54.9%-were between 30-39 years of age. Participants were almost equally distributed between educational groups, and about 87% had more than 2 years of experience. A brief overview showed a fair level of knowledge and attitude among 61.6% and 58.5% of respondents, respectively. Participants with an education level above that of high school showed good knowledge and attitude scores (p less then 0.05), whereas females showed better attitude scores compared to the males (p less then 0.05). Respondents mentioned the difficulties they faced while treating the subjects. The special healthcare workers generally had acceptable oral health knowledge and practices. #link# Caregivers who had lower education levels should be advised for training programs that addressed the importance of oral health services.Digital Twin technology has been rising in popularity thanks to the popularity of machine learning in the last decade. As the life expectancy of people around the world is increasing, so is the focus on physical activity to remain healthy especially in the current times where people are staying sedentary while in quarantine. This article aims to provide a survey on the field of Digital Twin technology focusing on machine learning and coaching techniques as they have not been explored yet. We also define what Digital Twin Coaching is and categorize the work done so far in terms of the objective of the physical activity. We also list common Digital Twin Coaching characteristics found in the articles reviewed in terms of concepts such as interactivity, privacy and security and also detail future perspectives in multimodal interaction and standardization, to name a few, that can guide researchers if they choose to work in this field. Finally, we provide a diagram for the Digital Twin Ecosystem showing the interaction between relevant entities and the information flow as well as an idealization of an ideal Digital Twin Ecosystem for team sports' athlete tracking.In this work, the plasma was used in the dielectric barrier discharge (DBD) technique for modifying the high-density polyethylene (HDPE) surface. The treatments were performed via argon or oxygen, for 10 min, at a frequency of 820 Hz, voltage of 20 kV, 2 mm distance between electrodes, and atmospheric pressure. The efficiency of the plasma was determined through the triple Langmuir probe to check if it had enough energy to promote chemical changes on the material surface. Physicochemical changes were diagnosed through surface characterization techniques such as contact angle, attenuated total reflection to Fourier transform infrared spectroscopy (ATR-FTIR), X-ray excited photoelectron spectroscopy (XPS), and atomic force microscopy (AFM). Plasma electronics temperature showed that it has enough energy to break or form chemical bonds on the material surface, impacting its wettability directly. The wettability test was performed before and after treatment through the sessile drop, using distilled water, glycerin, and dimethylformamide, to the profile of surface tensions by the Fowkes method, analyzing the contact angle variation. ATR-FTIR and XPS analyses showed that groups and bonds were altered or generated on the surface when compared with the untreated sample. The AFM showed a change in roughness, and this directly affected the increase of wettability.The Ras pathway is frequently deregulated in cancer, actively contributing to tumor development and progression. Oncogenic activation of the Ras pathway is commonly due to point mutation of one of the three Ras genes, which occurs in almost one third of human cancers. In the absence of Ras mutation, the pathway is frequently activated by alternative means, including the loss of function of Ras inhibitors. Among Ras inhibitors, the GTPase-Activating Proteins (RasGAPs) are major players, given their ability to modulate multiple cancer-related pathways. In selleck chemicals , most RasGAPs also have a multi-domain structure that allows them to act as scaffold or adaptor proteins, affecting additional oncogenic cascades. In cancer cells, various mechanisms can cause the loss of function of Ras inhibitors; here, we review the available evidence of RasGAP inactivation in cancer, with a specific focus on the mechanisms. We also consider extracellular inputs that can affect RasGAP levels and functions, implicating that specific conditions in the tumor microenvironment can foster or counteract Ras signaling through negative or positive modulation of RasGAPs. A better understanding of these conditions might have relevant clinical repercussions, since treatments to restore or enhance the function of RasGAPs in cancer would help circumvent the intrinsic difficulty of directly targeting the Ras protein.
The purposes of this study were to explore the resemblance in the weight status within couples with different family contextual factors and analyze the influence of the level of overweight or obesity of a spouse on that of the other spouse.

The data were from the sixth National Health Service Survey of Henan Province in 2018. After screening, 7432 eligible couples were finally included. Socioeconomic and demographic factors were compared by the χ
test or nonparametric test. The difference in the body mass index (BMI) of spouses was assessed by a t-test. The Pearson correlation coefficient and kappa value were used as indicators of consistency in weight status. A logistic regression analysis was used to further explore the effect of a spouse's level of overweight/obesity on that of the other spouse.

The results show that the prevalence of overweight/obesity in couples aged 20 or older is 33.76%. The Pearson correlation coefficient of the BMI within couples was 0.102 (95% CI 0.076-0.120). The kappa coefficients suggested a low resemblance in the weight status within couples (k = 0.
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