Notes

Maternity benefits throughout sufferers along with Alport syndrome.
AIMS To compare the policy positions of health and medical organisations across Australia, New Zealand, and the UK as they relate to sale and supply of nicotine vaping products (NVPs) and evaluate factors that have informed the differences in policy recommendations among these countries. selleck kinase inhibitor METHODS We used mixed methods to analyse data from position or policy statements published by health and medical organisations regarding NVPs (n = 30) and consultation documents submitted to government committees regarding policy options for the regulation of NVPs (n = 26). Quality assessment of included documents was conducted using the six-item Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Text and Opinion Papers, and findings were presented narratively. Qualitative data were coded using NVivo 12 software and analysed using thematic analysis. RESULTS An overwhelming majority of health bodies, charities and government agencies in the UK and New Zealand portrayed NVPs as a life-saving harm reduction tool. In contrast, concerns about addicting non-smoking youth to nicotine, a perceived lack of clear and convincing evidence of safety and efficacy and the potential to undermine tobacco control progress continues to define attitudes and recommendations towards NVPs among Australian health and medical organisations. Although the profoundly divided views among stakeholders seem to arise from empirical uncertainties and disagreements over the level and credibility of evidence, the source of most of these disagreements can be traced back to the fundamental and irreconcilable differences in the framing of the NVP debate, and varied tolerability of risk trade-offs associated with NVPs. CONCLUSION Progress in resolving the controversy surrounding NVP policy requires stakeholders to be frame-reflective and engage in a meaningful dialogue of risk trade-offs, as well as both intended and unintended consequences of proposed policies. BACKGROUND In New York City (NYC), 1,487 unintentional overdose deaths occurred in 2017, largely driven by the presence of fentanyls in the illicit drug market. In response to fentanyl-involved overdoses, law enforcement entities both nationally and in NYC have taken a new interest in overdose events. This study explored attitudes toward and willingness to engage with police among NYC syringe service program (SSP) participants, a population likely to have had experiences with overdose and/or police. METHODS Between March and July 2017, 332 surveys were conducted with a convenience sample of NYC SSP participants. RESULTS Most respondents (76%) reported ever being arrested for a drug-related crime. Few respondents (5%) reported a previous arrest in the context of an overdose event. Of the 62 respondents who had witnessed an overdose in the previous 12 months, 25% had not called 911 because of concerns about law enforcement. Over half (51%) of all respondents reported they would not be willing to aid police in their investigation of the person who supplied the drugs. CONCLUSION Police investigations of both fatal and non-fatal drug overdose events have the potential to exacerbate mistrust of law enforcement and discourage emergency medical service utilization among PWUD. INTRODUCTION Current discourses about the causes of the overdose crisis largely focus on the harmful effects of drugs. Prior research, however, indicates that drug use experience is shaped by complex interactions of drugs with physiological and mental "sets" of people who use drugs and the wider social and physical "setting." Zinberg's "drug, set, and setting" theoretical framework was applied to identify patterns in circumstances leading up to women's overdose. METHODS In-depth semi-structured interviews were conducted with 29 opioid-injecting street-involved women, clients of a Philadelphia harm reduction program. Qualitative analysis with deductive and inductive coding was utilized to examine transcripts for theory-driven and emerging themes. RESULTS Ten out of 29 women attributed their overdose to "drugs," reporting the unpredictable quality of street opioids, concurrent use of benzodiazepines, or chasing the "high." Thirteen women reported "set" as a type of circumstance where their emotional states were affected by a "good" or "bad" day, leading them to unusual drug consumption practices. Six women described "setting" type of circumstances where their overdose was preceded by a recent change in context, such as release from prison, which prompted unsafe drug use to address physiological or psychological dependence on drugs. CONCLUSION While all overdoses result from the pharmacological action of drugs, some overdoses were triggered by circumstances occurring in women's set or setting. Overdose prevention policies should embrace not only individual-level behavioral interventions, but also structural measures to address stress, social isolation, and risky drug use contexts that plague the lives of street-involved women who inject opioids. RATIONALE Although childhood maltreatment is known to be associated with non-suicidal self-injury (NSSI), few studies have investigated the mediating effect of self-esteem on this relationship. Additionally, it is unknown whether the impacts vary by sex or only-child status. OBJECTIVE We investigated the mediating effects of self-esteem on the relationship between childhood maltreatment and NSSI in adolescents and identified the significance of sex and only child status. METHOD An adolescent health survey was conducted in 15 schools in China between 2013 and 2014. In total, 9704 students aged 11-19 years completed standard questionnaires to report the details of childhood maltreatment, NSSI, and self-esteem. RESULTS Childhood maltreatment was negatively correlated with self-esteem and positively correlated with the frequency of NSSI. Lower self-esteem was also correlated with higher NSSI frequency. Self-esteem mediated the relationship between childhood maltreatment and NSSI, and the estimated ratio of the total effect of childhood maltreatment that could be explained by mediation through self-esteem was 16.3%. The ratio was higher in boys (28.6%) than in girls (9.9%), and it was higher in only children (31.5%) than in children with siblings (11.0%). CONCLUSIONS Childhood maltreatment is positively correlated with the frequency of NSSI and may be mediated by self-esteem. Interventions aimed at reducing NSSI associated with childhood maltreatment may be enhanced by efforts to strengthen self-esteem, especially in boys and only children.
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