Notes

Atypical dental candidiasis in a psoriatic affected individual during precise immunotherapy with the interleukin 19 inhibitor (secukinumab).
sk of intubation during resuscitation in very preterm infants.
To study the clustering and influencing factors of
carriage among kindergarten children, and to provide a scientific basis for the prevention of pneumococcal diseases.

The multi-stage stratified cluster sampling method was used to collect nasal swabs via the nasal vestibule at both sides from 1 702 kindergarten children in Liuzhou, China. A questionnaire survey was performed on their parents. The chi-square test and the random effects logistic regression analysis were used to analyze data.

The carriage rate of
was 13.16% (224/1 702) among kindergarten children. The clustering analysis showed that the class-level random effect of
carriage was statistically significant (
=2.07,
=0.038), with an intraclass correlation coefficient of 5.9%. The random effects logistic regression analysis showed that the children aged 5-7 years had a lower risk of
carriage than those aged 2-< 5 years (
=0.55, 95%
0.40-0.76,
=0.001), and the children with ≥ 5 family members living together had a higher risk of
carriage than those with < 5 family members (
=1.34, 95%
1.01-1.79,
=0.043).

carriage shows a class-level clustering effect, and age and the number of cohabitants are important influencing factors for
carriage in children.
Streptococcus pneumoniae carriage shows a class-level clustering effect, and age and the number of cohabitants are important influencing factors for Streptococcus pneumoniae carriage in children.
To systematically evaluate the efficacy and safety of levetiracetam (LEV) versus phenytoin (PHT) as second-line drugs for the treatment of convulsive status epilepticus (CSE) in children.

English and Chinese electronic databases were searched for the randomized controlled trials comparing the efficacy and safety of LEV and PHT as second-line drugs for the treatment of childhood CSE. RevMan 5.3 software was used for data analysis.

Seven studies with 1 434 children were included. The Meta analysis showed that compared with the PHT group, the LEV group achieved a significantly higher control rate of CSE (
=1.12, 95%
1.00-1.24,
=0.05), but there was no significant difference between the two groups in the recurrence rate of epilepsy within 24 hours (
=0.82, 95%
0.22-3.11,
=0.77) and the rate of further antiepileptic drug therapy (
=0.97, 95%
0.64-1.45,
=0.87). There was no significant difference in the incidence rate of adverse events between the two groups (
=0.77, 95%
0.55-1.09,
=0.15).

LEV has a better clinical effect than PHT in the treatment of children with CSE and does not increase the incidence rate of adverse events.
LEV has a better clinical effect than PHT in the treatment of children with CSE and does not increase the incidence rate of adverse events.
To study the change and significance of hippocampal volume (HCV) in children with recurrent febrile seizures.

A retrospective analysis was performed on the medical data and examination results of 34 children with recurrent febrile seizures who underwent two magnetic resonance plain scans of the head and the hippocampus from January 1, 2013 to September 30, 2019. According to the follow-up time, they were divided into the first follow-up group and the second follow-up group. According to prognosis, they were divided into a febrile seizure group, a non-febrile group and an epilepsy group. The change in HCV was analyzed and compared.

Total HCV was positively correlated with age (

=0.683,
< 0.05). The second follow-up group had a significantly larger total HCV than the first follow-up group (
< 0.05). For both groups, preschool children (≥ 3 years old) had significantly larger total HCV, left HCV, and right HCV than those at an age of < 3 years (
< 0.05). For both groups, the children with persistent seizures had significantly lower average annual increment (ΔV) of total HCV, left HCV, and right HCV than those without persistent seizures (
< 0.05). There was no significant difference in ΔV of total HCV, left HCV, and right HCV among the febrile seizure, non-febrile seizure and epilepsy groups (
> 0.05).

HCV gradually increases with age in children with recurrent febrile seizures. Persistent seizures may damage the development of the hippocampus.
HCV gradually increases with age in children with recurrent febrile seizures. Persistent seizures may damage the development of the hippocampus.
To evaluate the value of autism screening checklists in the early identification of autism spectrum disorder (ASD).

A total of 2 571 children who attended the Children's Hospital of Chongqing Medical University and completed autism screening and diagnostic test were enrolled as subjects, among whom 2 074 were diagnosed with ASD, 261 were diagnosed with global developmental delay (GDD), 206 were diagnosed with developmental language disorder (DLD), and 30 had normal development. The sensitivity, specificity, and optimal threshold value of the Modified Checklist for Autism in Toddlers (M-CHAT) and the Autism Behavior Checklist (ABC) for the early identification of ASD were evaluated by the receiver operating characteristic (ROC) curve.

The M-CHAT had a high sensitivity of 88.3% but a low specificity of 36.0% for the identification of ASD. U0126 Its sensitivity decreased with age, and was maintained above 80% for children aged 16 to < 48 months. The ABC had a high specificity of 87.3% but a low sensitivity of 27.2%, with an optimal cut-off value of 47.5 based on the ROC curve analysis. The multivariate linear regression model based on a combination of the M-CHAT and ABC for screening of ASD showed a specificity of 85.8% and a sensitivity of 56.6%.

The M-CHAT has a high sensitivity and a low specificity in the identification of ASD, with a better effect in children aged 16 to < 48 months. The ABC has a high specificity and a low sensitivity. The multiple linear regression model method based on the combined M-CHAT and ABC to screen ASD appears to be effective.
The M-CHAT has a high sensitivity and a low specificity in the identification of ASD, with a better effect in children aged 16 to less then 48 months. The ABC has a high specificity and a low sensitivity. The multiple linear regression model method based on the combined M-CHAT and ABC to screen ASD appears to be effective.
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