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Robot-assisted pancreatoduodenectomy in 3 hundred sequential cases: yearly pattern investigation and also inclination score-matched evaluation associated with perioperative as well as long-term oncologic outcomes using the open up technique.
We also demonstrated that the natural compound, ophiopogonin D, acts as a KLF3 inhibitor to promote vessels formation both in vitro and in vivo. Administration of ophiopogonin D increased the abundance of CD31hi Emcnhi vessels and accelerated bone healing. CONCLUSIONS Our findings confirmed the important role of CD31hi Emcnhi vessels in bone regeneration and provided a new target to treat bone fracture or promote bone regeneration. © 2020 The Authors. Cell Proliferation published by John Wiley & Sons Ltd.The origin of the positive temperature effect in fluorescence emission of a newly designed perylene bisimide (PBI) derivative with two naphthyl units containing ortho-methoxy group (NM) at its bay positions (PBI-2NM) was elucidated. A key point is the finding of a weak hydrogen bond ( less then 5.0 kcal mol-1 ) between the methoxy group of the NM unit and a nearby hydrogen atom of the PBI core. It is the bonding that drives co-planarization of the different aromatic units, resulting in delocalization of the π-electrons of the compound as synthesized, inducing fluorescence quenching via intramolecular charge transfer (ICT). With increasing temperature, the co-planar structure could be distorted in part, resulting in a decreased degree of ICT, and hence leading to enhanced fluorescence emission. The unique positive temperature effect in emission induced by H-bond-driven co-planarization may pave a new avenue in designing functional molecular systems complementary to conventional methods. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.Silicon-mediated fluoride abstraction is demonstrated as a means of generating the first fluorido-cyanido transition metal complexes. This new synthetic approach is exemplified by the synthesis and characterization of the heteroleptic complexes, trans-[M IV F 4 (CN) 2 ] 2- (M = Re, Os), obtained from their homoleptic [M IV F 6 ] 2- parents. As shown by combined high-field electron paramagnetic resonance spectroscopy and magnetization measurements, the partial substitution of fluoride by cyanide ligands leads to a dramatic increase in the magnetic anisotropy of trans-[ReF 4 (CN) 2 ] 2- as compared to [ReF 6 ] 2- , reflecting the severe departure from an ideal octahedral (O h point group) ligand field. This methodology paves the way toward the realization of new heteroleptic transition metal complexes that may be used as highly anisotropic building-blocks for the design of high-performance molecule-based magnetic materials. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Telomeres are DNA-protein structures located at the chromosome ends and terminating with an essential single-stranded 3'-overhang.1 Their role is to maintain genomic integrity by protecting chromosomes from degradation and illegitimate recombination. GSK-2879552 LSD1 inhibitor Telomeres progressively shorten during cell division because of the inability of DNA polymerase to replicate the 3'-end of chromosomes. Telomerase limits telomere attrition by synthesizing de novo telomere sequences at the end of chromosomes. This article is protected by copyright. All rights reserved.The onset of malignant mesothelioma (MM) is linked to exposure to asbestos fibers. Asbestos fibers are classified as serpentine (chrysotile) or amphibole, which includes the crocidolite, amosite, anthophyllite, tremolite and actinolite types. Although few studies have been conducted, anthophyllite has been shown to be associated with mesothelioma, and tremolite, a contaminant in talc and chrysotile, is a risk factor for carcinogenicity. Here, after characterizing the length and width of these fibers by scanning electron microscopy, we explored the cytotoxicity induced by tremolite and anthophyllite in cells from an immortalized human mesothelial cell line (MeT5A), murine macrophages (RAW264.7) and in a rat model. Tremolite and short anthophyllite fibers were phagocytosed and localized to vacuoles, while the long anthophyllite fibers were caught on the pseudopod of the MeT5A and Raw 264.7 cells, according to transmission electron microscopy. The results from a two-day time-lapse study revealed that tremolite was engulfed and damaged the MeT5A and RAW264.7 cells, while anthophyllite was not cytotoxic to these cells. Intraperitoneal injection of tremolite in rats induced diffuse serosal thickening, while anthophyllite formed focal fibrosis and granulomas on peritoneal serosal surfaces. Further, the loss of Cdkn2a/2b, which are the most frequently lost foci in human MM, were observed in eight cases of rat MM [homozygous deletion (5/8) and loss of heterozygosity (3/8)] by array-based comparative genomic hybridization techniques. These results indicate that tremolite initiates mesothelial injury and persistently frustrates phagocytes, causing subsequent peritoneal fibrosis and MM. The possible mechanisms of carcinogenicity based on fiber diameter/length are discussed. This article is protected by copyright. All rights reserved.OBJECTIVES To compare the effectiveness of lasers and topical desensitising agent treatments for dentine hypersensitivity. METHODS PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, and ISI Web of Knowledge were electronically searched without restrictions. Study search, selection, data extraction, and assessment of risk of bias were conducted independently by two reviewer authors. All analyses were performed using Review Manager 5.3 (Cochrane Collaboration, Copenhagen, Denmark). RESULTS This meta-analysis included 13 eligible studies that compared topical desensitising agents and NdYAG or diode laser. Four, six, and three studies were considered to have low, moderate, and high risks of bias, respectively. The follow-up period varied from immediate to 9 months. All comparisons except the 3-month NdYAG laser parallel group and 6-month diode laser group showed that the clinical efficacy of lasers for dentine hypersensitivity was not significantly different with topical desensitising agents. CONCLUSION We found low-quality evidence that was insufficient to draw any conclusions regarding the superiority of lasers or conventional topical desensitising agents in the treatment of DH. Further well-designed RCTs on this topic are needed to draw definitive conclusions. This article is protected by copyright. All rights reserved.
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