Notes

Imaging Charged Exciton Localization throughout lorrie der Waals WSe2/MoSe2 Heterobilayers.
Epithelial branching morphogenesis drives the development of organs such as the lung, salivary gland, kidney and the mammary gland. It involves cell proliferation, cell differentiation and cell migration. An elaborate network of chemical and mechanical signals between the epithelium and the surrounding mesenchymal tissues regulates the formation and growth of branching organs. Surprisingly, when cultured in isolation from mesenchymal tissues, many epithelial tissues retain the ability to exhibit branching morphogenesis even in the absence of proliferation. In this work, we propose a simple, experimentally plausible mechanism that can drive branching morphogenesis in the absence of proliferation and cross-talk with the surrounding mesenchymal tissue. The assumptions of our mathematical model derive from in vitro observations of the behaviour of mammary epithelial cells. These data show that autocrine secretion of the growth factor TGF[Formula see text]1 inhibits the formation of cell protrusions, leading to curvature-dependent inhibition of sprouting. Our hybrid cellular Potts and partial-differential equation model correctly reproduces the experimentally observed tissue-geometry-dependent determination of the sites of branching, and it suffices for the formation of self-avoiding branching structures in the absence and also in the presence of cell proliferation. This article is part of the theme issue 'Multi-scale analysis and modelling of collective migration in biological systems'.Collective migration, the movement of groups in which individuals affect the behaviour of one another, occurs at practically every scale, from bacteria up to whole species' populations. Universal principles of collective movement can be applied at all levels. In this review, we will describe the rules governing collective motility, with a specific focus on the neural crest, an embryonic stem cell population that undergoes extensive collective migration during development. We will discuss how the underlying principles of individual cell behaviour, and those that emerge from a supracellular scale, can explain collective migration. This article is part of the theme issue 'Multi-scale analysis and modelling of collective migration in biological systems'.We provide a review of recent advancements in non-local continuous models for migration, mainly from the perspective of its involvement in embryonal development and cancer invasion. Particular emphasis is placed on spatial non-locality occurring in advection terms, used to characterize a cell's motility bias according to its interactions with other cellular and acellular components in its vicinity (e.g. cell-cell and cell-tissue adhesions, non-local chemotaxis), but we also briefly address spatially non-local source terms. Following a short introduction and description of applications, we give a systematic classification of available PDE models with respect to the type of featured non-localities and review some of the mathematical challenges arising from such models, with a focus on analytical aspects. This article is part of the theme issue 'Multi-scale analysis and modelling of collective migration in biological systems'.In our digital societies, individuals massively interact through digital interfaces whose impact on collective dynamics can be important. In particular, the combination of social media filters and recommender systems can lead to the emergence of polarized and fragmented groups. In some social contexts, such segregation processes of human groups have been shown to share similarities with phase separation phenomena in physics. Here, we study the impact of information filtering on collective segregation behaviour of human groups. We report a series of experiments where groups of 22 subjects have to perform a collective segregation task that mimics the tendency of individuals to bond with other similar individuals. More precisely, the participants are each assigned a colour (red or blue) unknown to them, and have to regroup with other subjects sharing the same colour. To assist them, they are equipped with an artificial sensory device capable of detecting the majority colour in their 'environment' (defined as their k nearest neighbours, unbeknownst to them), for which we control the perception range, k = 1, 3, 5, 7, 9, 11, 13. We study the separation dynamics (emergence of unicolour groups) and the properties of the final state, and show that the value of k controls the quality of the segregation, although the subjects are totally unaware of the precise definition of the 'environment'. We also find that there is a perception range k = 7 above which the ability of the group to segregate does not improve. We introduce a model that precisely describes the random motion of a group of pedestrians in a confined space, and which faithfully reproduces and allows interpretation of the results of the segregation experiments. Finally, we discuss the strong and precise analogy between our experiment and the phase separation of two immiscible materials at very low temperature. ISA-2011B solubility dmso This article is part of the theme issue 'Multi-scale analysis and modelling of collective migration in biological systems'.
To compare the Pediatric Sleep Questionnaire (PSQ) and a less time-consuming set of 6 hierarchically arranged questions (6Q) as they relate to the pre-test probability for sleep apnea in pediatric patients.

Parents of 116 subjects between the ages of 7 and 17 answered two sleep questionnaires (the PSQ and the 6Q) distributed in random order before the subjects had sleep studies. Correlation coefficients were used for apnea-hypopnea index (AHI) prediction, while the area under the curve (AUC) was calculated for sleep apnea classification prediction.

The 6Q showed statistical significance, while the more commonly used PSQ did not, both in terms of correlating with AHI (rho=0.294,
=0.001) and predicting moderate and severe sleep apnea (AUC=0.650 and 0.788, respectively).

Although additional field validation is required, these pediatric sleep questionnaires are sensitive and easy-to-use screening tools that can greatly help in the screening for pediatric sleep apnea.
Although additional field validation is required, these pediatric sleep questionnaires are sensitive and easy-to-use screening tools that can greatly help in the screening for pediatric sleep apnea.
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