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Current Advancement In regards to the N-Arylation involving Indoles.
Angiotensin-converting enzyme (ACE) inhibitors have previously been associated with flushing and hypotension in patients undergoing TPE. Patients undergoing TPE have an activation of the prekallikrein and bradykinin system on contact with the extracorporeal membranes. ACE inhibitors potentiate this reaction by inhibiting bradykinin catabolism. Angiotensin receptor blockers (ARBs) have also been postulated to cause elevated bradykinin levels although data pertaining to the use of ARBs in TPE is limited. We hope to highlight this rare interaction in our case and emphasize the need for further data with regard to the same. Copyright © 2020, Ashok Kumar et al.Mollaret's meningitis is characterized by recurrent episodes of aseptic meningitis that last two to seven days and resolve spontaneously without any residual neurological deficit or complication. Viruses are the most common cause of aseptic meningitis and herpes simplex virus (HSV) type 2 has been noted as the most commonly associated virus in Mollaret's meningitis. We describe a rare case of a female who had four episodes of meningitis in a five-year period associated with chronic intractable migraine and papilledema attributed to Mollaret's meningitis. TD-139 in vivo Copyright © 2020, Gadhiya et al.Background Type 2 diabetes mellitus (T2DM) is associated with acute coronary syndrome, and elevated blood glucose levels on hospital admission may influence outcomes in patients with ST-elevated myocardial infarction (STEMI). We conducted this study to determine the prognostic outcome of hyperglycemia at admission on in-hospital outcomes of STEMI patients with and without T2DM. Methods This prospective study was conducted from June 13, 2018, to October 12, 2019, and included patients older than 18 years diagnosed with STEMI. For our purposes, hyperglycemia was defined as blood glucose levels >140 mg/dl. Hypertension was considered as systolic blood pressure >140 mmHg or diastolic pressure > 90 mmHg. The predictive value of glycemia on admission for outcomes was assessed via patient mortality following thrombolysis or percutaneous coronary intervention (PCI). Results Our study included 256 patients (196 men, 76.5%; 60 women, 23.5%) with a mean age of 55 ± 11 years. A total of 92 patients (35.9%) were admitted with known T2DM diagnoses 72 of them had hyperglycemia and 20 patients had euglycemia (p = 0.0001). Post-PCI mortality was six (18.8%) in the hyperglycemic group and one (2.2%) in the euglycemic group (p = 0.03). In-hospital mortality was higher in the hyperglycemic group (n = 12, 12.5%) compared to the euglycemic group (n = 6, 3.7%; p = 0.015). Significant risk factors of mortality for STEMI patients with hyperglycemia on admission were age 60 years or older (odds ratio [OR], 5.63 [1.54-20.58]; p = 0.007), heart failure on admission (OR, 6.84 [1.85-25.22)]; p = 0.003), T2DM (OR, 4.14 [0.50-33.96]; p = 0.05), and presenting with renal failure (OR, 6.78 [1.74-26.42]; p = 0.009). Conclusion Thrombolysis and PCI are effective and safe treatments in STEMI patients. Hyperglycemia has a great adverse impact on hospital outcomes in patients with or without T2DM. STEMI patients with hyperglycemia on hospital admission have higher mortality rates. Copyright © 2020, Shahid et al.Coronary arterial fistula (CAF) is an abnormal connection between one or both coronary arteries and a cardiac/extra-cardiac chamber or another vessel. Aortocoronary fistula is a rare type of CAF, which involves an anomalous connection between coronary arteries and any segment of aorta. The following case report describes the case of an adult male patient who presented with the complaint of typical chest pain. Coronary angiography was done and the diagnosis of severe three-vessel disease with an associated aortocoronary fistula was made. Coronary artery bypass grafting (CABG) was planned and performed, and the patient was discharged after a week postoperatively. Copyright © 2020, Naqvi et al.We would like to present a rare case of postoperative duodenal ischemia managed conservatively. This is an 83-year-old female who underwent an elective costotransversectomy and discectomy. The surgery was complicated by hypotension. Postoperative recovery was complicated by episodes of diarrhea and melena with a hemoglobin drop. Esophagogastroduodenoscopy (EGD) performed revealed diffusely ischemic duodenal mucosa affecting both the first and second parts. Computed tomography angiography failed to find occlusion of blood supply. The patient was managed conservatively with fluids and hemodynamic support. The blood supply to the duodenum is highly collateral making ischemia here rare. In similar case reports of successfully conservatively managed duodenal ischemia, EGD was also performed due to similar rare presentations and diagnostic challenges/uncertainties, despite EGD currently not being considered a useful adjunct in the diagnosis of acute mesenteric ischemia. They were also managed conservatively with fluid replacement, bowel reset, and proper selection of current medications. Copyright © 2020, Gupta et al.Statins are one of the most commonly used medications to lower cholesterol and have been known to cause various side effects including myalgias, myopathies, and rhabdomyolysis. Statin-induced necrotizing autoimmune myopathy (SINAM), a subtype of inflammatory myopathy, is an exceedingly rare but severe side effect of statin use that manifests as progressive muscle weakness. We describe a rapidly progressive case of SINAM in a 66-year-old Haitian female who developed debilitating symptoms after one month of statin use. Despite aggressive treatment with steroids and immunosuppressants, she failed to regain muscle strength and functional status, and remains on therapy. Given the widespread use of statins, it is important for clinicians to be aware of this condition and its presenting symptoms in order to initiate prompt treatment. Copyright © 2020, Ahmed et al.The purpose of this paper is to present a series of votive reliefs from Graeco-Roman antiquity related to disorders of the lower extremities, in order to comprehend the importance of anatomical offerings as gifts of gratitude to healing gods such as Asclepius. The selected offerings cover disorders such as varicose vein disease and deformities of the lower limbs and provide significant information on medical treatments in ancient Greece, as well as the importance of religious practices in the healing process. Copyright © 2020, Theodoraki et al.
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