Notes

[Generation as well as phenotypic portrayal of S100A9 gene knockout rodents through CRISPR/Cas9-mediated gene targeting].
However, nearly half of all papers reporting effects of propranolol did not provide an EC50 value. Some reported that very low concentrations of propranolol caused effects. The lowest concentration reported to cause an effect - in fact, a range of biochemical and physiological effects on mussels - was 0.3 ng/L. In none of these 'low concentration' papers was a sigmoidal concentration-response relationship obtained. Although inclusion of data from these papers in the ERA cause a change in the conclusion reached, we are sceptical of the repeatability of these 'low concentration' results. We conclude that concentrations of propranolol present currently in rivers throughout the world do not constitute a risk to aquatic organisms. We discuss the need to improve the quality of ecotoxicology research so that more robust ERAs acceptable to all stakeholders can be completed.Current debates identifying urban population density as a major catalyst for the spread of COVID-19, and the praise for de-densification and urban sprawl that they entail, may have dire environmental consequences. Juxtaposing competing theories about the urban antecedents of COVID-19, our key argument is that urban political attributes overshadow the effects of cities' spatial characteristics. This is true even when considering levels of compliance with movement restrictions and controlling for demographic and socio-economic conditions. Taking advantage of Israel as a living lab for studying COVID-19, we examine 271 localities during the first 3 months of the outbreak in Israel, a country where over 90% of the population is urban. check details Rather than density, we find social makeup and politics to have a critical effect. Cities with some types of political minority groups, but not others, exhibit higher infection rates. Compliance has a significant effect and density's influence on the spread of the disease is contingent on urban political attributes. We conclude with assessing how the relationship between the politics of cities and the spread of contagious diseases sheds new light on tensions between neo-Malthusian sentiments and concerns about urban sprawl and environmental degradation.Pesticides occur in urban streams globally, but the relation of occurrence to urbanization can be obscured by regional differences. In studies of five regions of the United States, we investigated the effect of region and urbanization on the occurrence and potential toxicity of dissolved pesticide mixtures. We analyzed 225 pesticide compounds in weekly discrete water samples collected during 6-12 weeks from 271 wadable streams; development in these basins ranged from undeveloped to highly urbanized. Sixteen pesticides were consistently detected in 16 urban centers across the five regions-we propose that these pesticides comprise a suite of urban signature pesticides (USP) that are all common in small U.S. urban streams. These USPs accounted for the majority of summed maximum pesticide concentrations at urban sites within each urban center. USP concentrations, mixture complexity, and potential toxicity increased with the degree of urbanization in the basin. Basin urbanization explained the most variability in icity testing.A major gap in understanding nanomaterials behaviour in the environment is a lack of reliable tools to measure their available concentrations. In this research we use diffusive gradients in thin films (DGT) for measuring concentrations of zinc oxide nanoparticles (ZNO NPs) in soils. Available nanoparticle concentrations were assessed by difference, using paired DGT devices with and without 1000 MWCO dialysis membranes to exclude NPs. We used ZnO because its toxic effects are accelerated through dissolution to Zn2+. Our test soils had different pH and organic matter (OM) contents, which both affect the dissolution rate of ZnO NPs. Woburn (pH ≈ 6.9, OM ≈ 1.8%) and Lufa (pH ≈ 5.9, OM ≈ 4.2%) soils were spiked to a single concentration of 500 mg of ZnO NPs per 1 kg of soil and the available concentrations of ZnO NPs and dissolved zinc were evaluated in 3, 7, 14, 21, 28, 60, 90, 120, 150 and 180 day intervals using DGT. The results showed that the dissolution of ZnO NPs, as well as the available concentrations of both dissolved and nanoparticulate Zn, was much higher in Lufa soil than in Woburn. This work demonstrates that DGT can be used as a simple yet reliable technique for determining concentrations of ZnO NPs in soils and probing its dissolution kinetics.Large population increases of Arctic-breeding waterfowls over recent decades have intensified the conflict with agricultural interests in both Eurasia and North America. In the spring-staging region Vesterålen in sub-Arctic Norway, sheep, dairy and meat farmers have reported reduced agricultural grassland yields due to pink-footed geese Anser brachyrhynchus and barnacle geese Branta leucopsis that rest and forage in the region for 3-4 weeks in spring on their way to their breeding grounds on Svalbard. Here, we report from an experimental exclosure design where goose access to plots at three grassland fields in Vesterålen was prevented. The experiment was conducted over 3 years between 2012 and 2014. Goose abundance varied greatly between fields and years as a function of variable spring weather and forage quantity, facilitating evaluation of longer-term impacts under contrasting grazing intensities. First and second harvest yields across fields and years were 20% and 19% higher in exclosures than in plots open for grazing, while total yields (sum of first and second harvests) were on average 27% higher. Within-year effects on harvest yields varied substantially, primarily due to highly contrasting sward development during the spring-staging periods. Cool weather (2012) led to slow sward development and little or no effects on harvest yields, warmer weather (2013) resulted in generally large effects, while variable weather (2014) led to treatment effects varying across fields, with one field experiencing 61% higher yields in exclosures while there were no significant impacts on first-harvest yields at the two other fields. Goose grazing did not increase dry weight-based proportions of weeds. Overall, the farmers' reports on yield-loss due to goose grazing were confirmed, although impacts varied substantially between years. A novel finding is that second-harvest yields were also reduced. For the most affected farmers, it is unlikely that the current subsidy scheme is sufficient to cover all the their losses.
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