Notes

The were living entire body (Som Leib) as a analytical as well as healing tool in general training.
Venomous animals hunt using bioactive peptides, but relatively little is known about venom small molecules and the resulting complex hunting behaviors. Here, we explored the specialized metabolites from the venom of the worm-hunting cone snail, Conus imperialis Using the model polychaete worm Platynereis dumerilii, we demonstrate that C. imperialis venom contains small molecules that mimic natural polychaete mating pheromones, evoking the mating phenotype in worms. The specialized metabolites from different cone snails are species-specific and structurally diverse, suggesting that the cones may adopt many different prey-hunting strategies enabled by small molecules. Predators sometimes attract prey using the prey's own pheromones, in a strategy known as aggressive mimicry. Instead, C. Selleck Senaparib imperialis uses metabolically stable mimics of those pheromones, indicating that, in biological mimicry, even the molecules themselves may be disguised, providing a twist on fake news in chemical ecology.The term "diversity," although widely used, can mean different things. Diversity can refer to heterogeneity, i.e., the distribution of people across groups, or to the representation of specific minority groups. We use a conjoint experiment with a race-balanced, national sample to uncover which properties, heterogeneity or minority representation, Americans use to evaluate the extent of racial diversity a neighborhood and whether this assessment varies by participants' race. We show that perceived diversity is strongly associated with heterogeneity. This association is stronger for Whites than for Blacks, Latinos, or Asians. In addition, Blacks, Latinos, and Asians view neighborhoods where their own group is largest as more diverse. Whites vary in their tendency to associate diversity with representation, and Whites who report conservative stances on diversity-related policy issues view predominately White neighborhoods as more diverse than predominately Black neighborhoods. People can agree that diversity is desirable while disagreeing on what makes a community diverse.Glucose-dependent insulinotropic polypeptide (GIP) communicates nutrient intake from the gut to islets, enabling optimal levels of insulin secretion via the GIP receptor (GIPR) on β cells. The GIPR is also expressed in α cells, and GIP stimulates glucagon secretion; however, the role of this action in the postprandial state is unknown. Here, we demonstrate that GIP potentiates amino acid-stimulated glucagon secretion, documenting a similar nutrient-dependent action to that described in β cells. Moreover, we demonstrate that GIP activity in α cells contributes to insulin secretion by invoking paracrine α to β cell communication. Last, specific loss of GIPR activity in α cells prevents glucagon secretion in response to a meal stimulus, limiting insulin secretion and driving glucose intolerance. Together, these data uncover an important axis by which GIPR activity in α cells is necessary to coordinate the optimal level of both glucagon and insulin secretion to maintain postprandial homeostasis.The prevention of work-related upper extremity musculoskeletal disorders (MSDs; e.g., neck pain and shoulder fatigue) requires frequent exercises of neck and shoulder that primarily rely on the assistance of joint motion monitoring devices. However, most available wearable healthcare sensors are rigid, bulky, and incapable of recognizing the full range of human motions. Here, we propose a kirigami-structured highly anisotropic piezoelectric network composite sensor that is able to monitor multiple information of joint motions, including bending direction, bending radius, and motion modes, and to distinguish them simultaneously within one sensor unit. On the basis of the modified template-assisted processing method, we design a functional piezoceramic kirigami with a honeycomb network structure that is stretchable (~100% strain), highly sensitive (15.4 mV kPa-1), and highly anisotropic to bending directions (17.3 times from 90° to 0°). An integrated monitoring system is further established to alarm the prolonged sedentary behaviors, facilitating the prevention of upper extremity MSDs.In separation and catalysis applications, adsorption and diffusion are normally considered mutually exclusive. That is, rapid diffusion is generally accompanied by weak adsorption and vice versa. In this work, we analyze the anomalous loading-dependent mechanism of p-xylene diffusion in a newly developed zeolite called SCM-15. The obtained results demonstrate that the unique system of "continuum intersecting channels" (i.e., channels made of fused cavities) plays a key role in the diffusion process for the molecule-selective pathways. At low pressure, the presence of strong adsorption sites and intersections that provide space for molecule rotation facilitates the diffusion of p-xylene along the Z direction. Upon increasing the molecular uptake, the adsorbates move faster along the X direction because of the effect of continuum intersections in reducing the diffusion barriers and thus maintaining the large diffusion coefficient of the diffusing compound. This mechanism synergistically improves the diffusion in zeolites with continuum intersecting channels.Here, we present an approach to model and adapt the mechanical regulation of morphogenesis that uses contractile cells as sculptors of engineered tissue anisotropy in vitro. Our method uses heterobifunctional cross-linkers to create mechanical boundary constraints that guide surface-directed sculpting of cell-laden extracellular matrix hydrogel constructs. Using this approach, we engineered linearly aligned tissues with structural and mechanical anisotropy. A multiscale in silico model of the sculpting process was developed to reveal that cell contractility increases as a function of principal stress polarization in anisotropic tissues. We also show that the anisotropic biophysical microenvironment of linearly aligned tissues potentiates soluble factor-mediated tenogenic and myogenic differentiation of mesenchymal stem cells. The application of our method is demonstrated by (i) skeletal muscle arrays to screen therapeutic modulators of acute oxidative injury and (ii) a 3D microphysiological model of lung cancer cachexia to study inflammatory and oxidative muscle injury induced by tumor-derived signals.
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