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Typical pathways in dementia and also diabetic retinopathy: knowing the components involving diabetes-related psychological decline.
Copyright © 2020 Wisniewski, Zierer and Hattie.Altruism can be spontaneously aroused by environmental factors. However, the mechanism behind these factors is subject to debate. We carried out a study of laboratory experiment using computer-based Mouselab method to determine the mechanism. We found that different colors altered the altruistic behaviors of people. Specifically, blue enhanced altruism, whereas red discouraged altruism. We used a process-tracing technique to monitor the selection of an adaptive strategy and demonstrate that different colors can simulate changes in information acquisition and then lead to the corresponding behaviors. The results suggested that the decision heuristic plays a mediating role in the link between colors and individual altruistic behaviors. Copyright © 2020 Nie, Lin, Tu, Fan and Wu.Computerized adaptive testing (CAT) is an efficient testing mode, which allows each examinee to answer appropriate items according his or her latent trait level. The implementation of CAT requires a large-scale item pool, and item pool needs to be frequently replenished with new items to ensure test validity and security. Online calibration is a technique to calibrate the parameters of new items in CAT, which seeds new items in the process of answering operational items, and estimates the parameters of new items through the response data of examinees on new items. The most popular estimation methods include one EM cycle method (OEM) and multiple EM cycle method (MEM) under dichotomous item response theory models. This paper extends OEM and MEM to the graded response model (GRM), a popular model for polytomous data with ordered categories. Two simulation studies were carried out to explore online calibration under a variety of conditions, including calibration design, initial item parameter calculation methods, calibration methods, calibration sample size and the number of categories. Results show that the calibration accuracy of new items were acceptable, and which were affected by the interaction of some factors, therefore some conclusions were given. Copyright © 2020 Xiong, Ding, Luo and Luo.This article aims to investigate the interaction effects of emotional valence (negative, positive) and stimulus type (sticker, face) on attention allocation and information retrieval in spatial working memory (WM). The difference in recognition of emotional faces and stickers was also further explored. Using a high-resolution event-related potential (ERP) technique, a time-locked delayed matching-to-sample task (DMST) was employed that allowed separate investigations of target, delay, and probe phases. Twenty-two subjects participated in our experiment. The results indicated that negative face can catch early attention in information encoding, which was indicated by the augmentation of the attention-related P200 amplitude. In the delay phase, the N170 component represents facial specificity and showed a negative bias against stickers. For information retrieval, the increase in the emotion-related late positive component (LPC) showed that positive emotion could damage spatial WM and consume more cognitive resources. Moreover, stickers have the ability to catch an individual's attention throughout the whole course of spatial WM with larger amplitudes of the attention-related P200, the negative slow wave (NSW), and the LPC. selleck chemical These findings highlight the role of stickers in different phases of spatial WM and provide new viewpoints for WM research on mental patients. Copyright © 2020 Li, Li, Ren, Chen and Yang.Introduction Pruritus is the primary symptom of atopic dermatitis (AD). The objective of this study was to develop a patient-reported outcome (PRO) instrument for daily administration in clinical trials to measure AD-related itch in adolescents and adults that would meet the standards described in the US Food and Drug Administration's (FDA's) PRO Guidance.Materials and methods Six focus groups were conducted with 49 patients with AD (32 adults; 17 adolescents). Three iterative rounds of cognitive debriefing interviews were conducted in 26 patients with AD (17 adults; 9 adolescents) to pretest and refine the instrument.Results AD-related itching was considered the most bothersome AD symptom by nearly two-thirds of the focus group participants. The items in the initial version of the instrument, named the Atopic Dermatitis Itch Scale (ADIS), were developed to reflect concepts most relevant to the assessment of itching as described during the focus groups. Based on results of the cognitive debriefing interviews, an 8-item final version of the ADIS was created.Conclusion The ADIS is a content valid PRO instrument addressing the concepts critical to the measurement of AD-related itching. To our knowledge, it is the first instrument developed to assess AD-related itch in patients as young as 12 years following the recommendations of the PRO Guidance.Objective To identify the amino acid (AA) and acylcarnitines (ACs) profiles in dry blood spot (DBS) of small, appropriate and large for gestational age neonates, and to investigate the difference AA and AC profiles in groups.Methods Eight thousand nine hundred and fourteen healthy singleton newborns were divided into three groups small for gestational age (SGA) (n = 713), appropriate for gestational age (AGA) (n = 7866), and LGA (n = 335). Electrospray ionization tandem mass spectrometry was taken to evaluate the concentrations of 11 AAs and 31 ACs in DBS specimens obtained from all enrolled neonates.Results Compared with the AGA neonates, except propionylcarnitine, the concentrations of SGA neonatal most AAs and AC in the newborn were higher, while those of the newborns in the LGA group were lower.Conclusion Different concentrations of AAs and ACs in the three groups suggest that SGA may be associated with under anabolic metabolism, while LGA may be associated with over anabolic metabolism.This work aims to understand intra- and interprofessional networks of general practitioners (GPs) and ear, nose, and throat specialists (ENT specialists), and in what manner supervisors in these specialties involve interns in their professional network to help them learn intra- and interprofessional collaboration. An egocentric social network approach was used to collect and analyze quantitative as well as qualitative data. For this, semi-structured interviews were held with ten GP and ten ENT specialists. GPs had significantly more interprofessional contacts than ENT specialists (p less then .01), with no significant difference in the network sizes of both professions (p = .37). All supervisors involved interns in their (ego)network actively as well as more passively. They actively discussed how collaboration with other professionals evolved, or passively assumed that an intern would learn from observing the supervisors' network interactions. Many supervisors considered the interns' initiative essential in deciding to involve an intern in their network.
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