Notes

Cost-Utility regarding Catheter Ablation pertaining to Atrial Fibrillation in Patients with Coronary heart Failure: An Economic Assessment.
Course-based undergraduate research experiences (CUREs), which often engage students as early as freshman year, have become increasingly common in biology curricula. While many studies have highlighted the benefits of CUREs, little attention has been paid to responsible and ethical conduct of research (RECR) education in such contexts. Given this observation, we adopted a mixed methods approach to explore the extent to which RECR education is being implemented and assessed in biological sciences CUREs nationwide. Survey and semistructured interview data show a general awareness of the importance of incorporating RECR education into CUREs, with all respondents addressing at least one RECR topic in their courses. However, integration of RECR education within the CURE environment primarily focuses on the application of RECR during research practice, often takes the form of corrective measures, and appears to be rarely assessed. Participants reported lack of time and materials as the main barriers to purposeful inclusion of RECR education within their courses. These results underscore a need for the CURE community to develop resources and effective models to integrate RECR education into biology CUREs.Pinellia ternata (Thunb.) Makino ex Briet. (banxia, crow-dipper) is a perennial herbaceous plant native to China, Japan, and Korea. A member of the family Araceae, it is considered an invasive weed in parts of Europe and North America. In August 2020, P. ternata plants showing blight symptoms (8% incidence in a 30-ha field) were observed, near Qianjiang City (30°50'N, 112°92'E), Hubei Province, China. Brown water-soaked lesions first appeared on flowers followed by flower blight and leaf and stem rot during periods of more than 80% humidity (Supplementary figure 1). White, cottony mycelia grew from rotted tissues and produced sporangiophores with brown to black sporangiola. To identify the causal agent, 12 diseased samples were surface disinfested with 0.5% sodium hypochlorite and 75% ethyl alcohol, then plated on potato dextrose agar (PDA) maintained at 25°C. Ten fungal isolates were selected by hyphal tip isolation and placed on fresh PDA. White fungal colonies grew rapidly that later turned pale yellow andAgricultural Science and Technology Innovation Center Project (grant no.2019-620-003-001).
Coronary artery calcification (CAC) and carotid artery intima-media thickness (cIMT) are measures of subclinical atherosclerosis in asymptomatic individuals and strong risk factors for cardiovascular disease. Type 2 diabetes (T2D) is an independent cardiovascular disease risk factor that accelerates atherosclerosis.

We performed meta-analyses of genome-wide association studies in up to 2500 T2D individuals of European ancestry (EA) and 1590 T2D individuals of African ancestry with or without exclusion of prevalent cardiovascular disease, for CAC measured by cardiac computed tomography, and 3608 individuals of EA and 838 individuals of African ancestry with T2D for cIMT measured by ultrasonography within the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium.

We replicated 2 loci (rs9369640 and rs9349379 near
and rs10757278 near
) for CAC and one locus for cIMT (rs7412 and rs445925 near
) that were previously reported in the general EA populations. We identified one novel CAC locus (rs8000449 near
at 13q13.3) at
=2.0×10
in EA. No additional loci were identified with the meta-analyses of EA and African ancestry. The expression quantitative trait loci analysis with nearby expressed genes derived from arterial wall and metabolic tissues from the Genotype-Tissue Expression project pinpoints
, encoding a matricellular protein involved in bone formation and bone matrix organization, as the potential candidate gene at this locus. In addition, we found significant associations (
<3.1×10
) for 3 previously reported coronary artery disease loci for these subclinical atherosclerotic phenotypes (rs2891168 near
and rs11170820 near
for CAC, and rs7412 near
for cIMT).

Our results provide potential biological mechanisms that could link CAC and cIMT to increased cardiovascular disease risk in individuals with T2D.
Our results provide potential biological mechanisms that could link CAC and cIMT to increased cardiovascular disease risk in individuals with T2D.A fiducial cross section for Wγ production in proton-proton collisions is measured at a center-of-mass energy of 13 TeV in 137  fb^-1 of data collected using the CMS detector at the LHC. The W→eν and μν decay modes are used in a maximum-likelihood fit to the lepton-photon invariant mass distribution to extract the combined cross section. The measured cross section is compared with theoretical expectations at next-to-leading order in quantum chromodynamics. In addition, 95% confidence level intervals are reported for anomalous triple-gauge couplings within the framework of effective field theory.Inertial-range features of turbulence are investigated using data from experimental measurements of grid turbulence and direct numerical simulations of isotropic turbulence simulated in a periodic box, both at the Taylor-scale Reynolds number R_λ∼1000. In particular, oscillations modulating the power-law scaling in the inertial range are examined for structure functions up to sixth-order moments. The oscillations in exponent ratios decrease with increasing sample size in simulations, although in experiments they survive at a low value of 4 parts in 1000 even after massive averaging. The two datasets are consistent in their intermittent character but differ in small but observable respects. Epigenetic Reader Do modulator Neither the scaling exponents themselves nor all the viscous effects are consistently reproduced by existing models of intermittency.Dielectric particles in weakly conducting fluids rotate spontaneously when subject to strong electric fields. Such Quincke rotation near a plane electrode leads to particle translation that enables physical models of active matter. In this Letter, we show that Quincke rollers can also exhibit oscillatory dynamics, whereby particles move back and forth about a fixed location. We explain how oscillations arise for micron-scale particles commensurate with the thickness of a field-induced boundary layer in the nonpolar electrolyte. This work enables the design of colloidal oscillators.
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