Notes

Order as well as maintenance of disgust reactions in the Obsessive-compulsive disorder analogue trial: Effectiveness of termination strategies through a counter-conditioning procedure.
626). A previous abdominal surgery was present in 37.5 % and 33.7% of laparoscopy and laparotomy group, respectively (p=0.449). Laparoscopy had a lower incidence of distal catheter failure (OR 0.52, 95% CI 0.38-0.72; p<0.001). No differences were revealed about the duration of surgery, LOS and infection rate.

Laparoscopic technique has a lower risk of distal catheter failure in ventriculoperitoneal shunt for the treatment of hydrocephalus. Duration of surgery, LOS and infection rate are independent by the surgical technique. The overall level of evidence is low, and no absolute conclusions can be drawn.

Hand-Assisted Laparoscopy, Hydrocephalus, Meta-Analysis, Mini-Laparotomy, Shunt Failure, Shunt Malfunction, Ventriculoperitoneal Shunt.
Hand-Assisted Laparoscopy, Hydrocephalus, Meta-Analysis, Mini-Laparotomy, Shunt Failure, Shunt Malfunction, Ventriculoperitoneal Shunt.
This study aimed to explore the role of the PI3K/AKT signaling pathway in bFGF/PDGF composite hydrogel promoting the repair of spinal cord injuries.

In this study, the spinal cord injury rat model was established using Allen's punch method. selleck chemical Healthy male Sprague Dawley rats of the clean grade were randomly divided into four groups (n=18, each) sham operation group (group S), bFGF/PDGF composite hydrogel group (group A), bFGF/PDGF composite hydrogel + LY294002 (PI3K/AKT signaling pathway inhibitor) group (group B) and bFGF/PDGF composite hydrogel + IGF-1 (PI3K/AKT signaling pathway agonist) group (group C). After the operation, the motor function of the posterior limbs, the apoptosis of the spinal cord cells and the expression of PI3K, Akt and phosphorylated Akt (p-Akt) in the spinal cord tissues of the rats in each group were detected.

BBB joint score were significantly higher (P<0.05).

BFGF/PDGF composite hydrogel can significantly promote the repair of spinal cord injuries and the mechanism is closely correlated to the activation of the PI3K/AKT signaling pathway.

BFGF, Cell apoptosis, PDGF, PI3K/Akt signaling pathway, Spinal cord injury.
BFGF, Cell apoptosis, PDGF, PI3K/Akt signaling pathway, Spinal cord injury.
We aim to evaluate the prognostic significance of tumor volume in esophageal cancer.

Patients who underwent curative resection due to esophageal cancer between the years 2015 and 2019 were included in the study. The Tumor Depth Parameter (TDP) was defined as mucosa and submucosa =1, muscularis propria =2, adventitia =3, and invasion into adjacent organs=4. The Tumor Volume Index (TVI) was defined as the major axis X the minor axis X TDP. Two groups were formed based on TVI Group 1 (low TVI) and Group 2 (high TVI). In the groups; patients were compared in terms of demographic and clinical features, intraoperative and postoperative outcomes, characteristics of the tumor and average survival.

The patients were divided into two groups based on the cut-off value of 4,000. Group 1 (low TVI) consisted of 16 patients and Group 2 (high TVI) consisted of 28 patients. Male sex ratio was higher in Group 2 (50% vs 85%, p0.011) Tumor diameter was observed to be larger in Group 2 (3.06 vs 5.54, p0.000). Adenocarcinoma histologic type was more common in Group 2 (25% vs 64.3%, p0.012). Incidence of respiratory complications was higher in Group 2 (0% vs 35.7%, p0.024),Survival time (months) was shorter in Group 2 (36 vs 11, p0.005). TVI's being over 4000 (HR)(95%-Confidence Interval ((Cl) 0.057 (0.011-0.311),p0.001) was an independent risk factor to determine the rate of survival.

TVI can be used as a prognostic factor in patients with esophageal cancer who underwent surgical therapy. TVI is closely associated with tumor histology and postoperative outcomes.

Esophageal cancer, Prognosis, Postoperative complication, Surgical manangment, Survey, Tumor volume.
Esophageal cancer, Prognosis, Postoperative complication, Surgical manangment, Survey, Tumor volume.
There is no consensus regarding optimal timing or best surgical procedure for refractory renal hyperparathyroidism patients. We aim to compare the results after three types of parathyroidectomies performed for sHPT in a single referral centre.

This study included patients on chronic hemodialysis submitted to three types of parathyroidectomy between 2010 and 2017. The primary outcome measure was relief of the symptoms and normalization of the main biochemical parameters.

All symptoms improved significantly after surgery, especially osteoatricular pains. iPth dropped significantly immediately and during the follow up in all 3 groups; on short term, iPth values for group C(tPtx) were significantly lower compared to the other 2 subgroups (p=0.009). Furthermore, 5 patients from group C presented iPth values <12 pg/ml one year post-surgery, though this values tend to improve after. Patients from group B and C developed most often acute postoperative hypocalcemia, and persistent hyperparathyroidism was encountered especially after sPtx(10.3%).

Significant improvement of both symptoms and biochemical parameters was noted in the majority of cases, regardless the parathyroidectomy type. tPtx is frequently followed by chronic hypoparathyroidism and subtotal parathyroidectomy is followed by a higher number of persistent and recurrent sHPT.

Secondary hyperparathyroidism, Parathyroidectomy, Parathyroid autotransplant.
Secondary hyperparathyroidism, Parathyroidectomy, Parathyroid autotransplant.
This study is aimed at verifying the effect of specific management modalities aimed at reducing or preventing the incidence of infections in the blood flow in relation to the use of the central venous catheter (CRBSI = catheterrelated bloodstream infection) in patients undergoing chemotherapy.

36 patients (n = 36) with a peripherally inserted venous catheter (PICC) were enrolled in the integrated medical treatment group, while 128 patients with an internal central venous catheter were enrolled in the control group. The patients in the control group underwent routine nursing, while the patients in the treatment group underwent integrated surveillance control infection treatment by doctors and were compared between these two groups l incidence of complications, CRBSI.

The incidence of complications of the CRBSI type was significantly lower in the whole treatment group than in the control group and the difference was statistically significant (p <0.05).

It is concluded that the implementation of the infection control management modality within the integration of medical care for PICC chemotherapy patients in the Oncology Department can effectively reduce the incidence of infectious complications in the bloodstream, and improve the level of nursing care in peripheral venous catheterization (PICC) with improved patient satisfaction.
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