Notes

NK-/T-cell lymphomas.
δ-opioid receptor (DOPr) agonists have analgesic efficacy in chronic pain models but development of tolerance limits their use for long-term pain management. Although agonist potential for inducing acute analgesic tolerance has been associated with distinct patterns of DOPr internalization, the association between trafficking and chronic tolerance remains ill-defined. In a rat model of streptozotocin (STZ)-induced diabetic neuropathy, deltorphin II and TIPP produced sustained analgesia following daily (intrathecal) i.t. injections over six days, whereas similar treatment with SNC-80 or SB235863 led to progressive tolerance and loss of the analgesic response. see more Trafficking assays in murine neuron cultures showed no association between the magnitude of ligand-induced sequestration and development of chronic tolerance. Instead, ligands that supported DOPr recycling were also the ones producing sustained analgesia over 6-day treatment. Moreover, endosomal endothelin-converting enzyme 2 (ECE2) blocker 663444 prevented DOPr recycling by deltorphin II and TIPP and precipitated tolerance by these ligands. In conclusion, agonists, which support DOPr recycling, avoid development of analgesic tolerance over repeated administration. © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.BACKGROUND & AIMS Whether nonalcoholic fatty liver disease (NAFLD) is associated with risk of incident atrial fibrillation (AF) independent of established cardiovascular risk factors remains controversial. We aimed to provide a quantitative estimate of the association between NAFLD and risk of AF after adjustment for cardiometabolic risk factors. METHODS In this study, we searched PubMed and Embase for studies published from database inception until January 31, 2020. Cohort studies reported adjusted relative risks (RRs) and 95% confidence intervals (CIs) for AF of NAFLD compared with non-NAFLD were included for analysis. RESULTS A total of 6 cohort studies were included, comprising 614,673 individuals for analysis. The median follow-up duration was 10.0 years with 7,271 cases of incident AF. Compared with non-NAFLD, minimally adjusted models without adjustment for cardiometabolic risk factors showed that NAFLD was associated with increased risk of AF (RR 1.65, 95% CI 1.23-2.20, I2 = 63.0%). After adjustment for multiple cardiometabolic risk factors, the association between NAFLD and risk of AF was still higher than that in non-NAFLD (RR 1.19, 95% CI 1.04-1·31, I2 = 54.0%). There was significant heterogeneity for the risk of AF between minimally and maximally adjusted models (I2 = 77.1%, P for heterogeneity = 0.04). Compared with non-NAFLD, the absolute risk increase in NAFLD for AF was 1.3 (95% CI 0.5-2.1) per 1000 person-years. CONCLUSIONS NAFLD is associated with increased risk of incident AF. The strength of the association between NAFLD and AF is partially attributed to the co-existing cardiometabolic risk factors. This article is protected by copyright. All rights reserved.Absent, small or homeotic 2-like protein (ASH2L) is a core component of multimeric histone methyltransferase complex, which is involved in maintenance of active transcription, participating in several cancers. However, the biological function and molecular mechanism of ASH2L in endometrial cancer (ECa) is largely unknown. Endometrial cancer is one of the common female malignant tumors and the incidence is on the rise. Estrogen-ERα signaling as an oncogenic pathway, plays a crucial role in endometrial carcinogenesis. Thus, further exploring the molecular mechanism around ERα-mediated gene transcription in ECa would be helpful to understand the tumor development and to find a new therapeutic target for ECa. Here, our study demonstrated that ASH2L was highly expressed in ECa samples, and the higher expression of ASH2L was positively correlated with the poor prognosis. Moreover, we identified that ASH2L associated with ERα and knockdown of ASH2L resulted in decreased expression of a subset of the estrogen-induced target genes, including paired box 2 (PAX2), an oncogenic gene in ECa. ASH2L was recruited to cis-regulatory elements at PAX2, thereby altering histone H3K4me3 and H3K27me3 levels, to enhance ERα-mediated transactivation. Finally, depletion of ASH2L suppressed endometrial cancer cell proliferation and migration. Our findings suggest that ASH2L participates in promotion of ECa progression, if not all, at least partially via upregulation of PAX2 transcription. This article is protected by copyright. All rights reserved.I congratulate the authors for this well designed randomised controlled trial [BJOG 2020 xxxx]. The study compared laparoscopic sacrohysteropexy (LSH) to vaginal sacrospinous hysteropexy (SSHP) for the treatment of women with POP-Q stage ≥2 uterine prolapse in the absence of an indication for a concomitant hysterectomy. The authors of the LAVA-trial concluded that LSH was non-inferior to SSHP based on their composite primary outcome of recurrence of a POP-Q ≥ 2 uterine prolapse with bothersome bulging/protrusion symptoms and/or repeat surgery or pessary at 12 months postoperative. This article is protected by copyright. All rights reserved.This journal recently published a paper by Suso-Marti et al., entitled "Effectiveness of motor imagery and action observation training on musculoskeletal pain intensity A systematic review and meta-analysis" (2020). Motor imagery training and action observation training are rehabilitation approaches that involve imagining oneself executing a particular action, and watching actions that are performed by others, respectively. Both are thought to activate similar neural substrates that are responsible for the actual execution of an action (Eaves et al., 2016). Motor imagery and action observation have been used to enhance motor skill performance in several groups - including athletes and musicians who require highly accurate and precise movement for professional performances, and a similar approach has been employed during rehabilitation with variable outcomes in people after stroke, spinal cord injury and persistent pain. This article is protected by copyright. All rights reserved.
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