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Initial encounter & rationale of main allo Simple Limbal Epithelial Hair loss transplant (SLET) right after medical removal involving Ocular Floor Cancers.
Hepatitis C virus (HCV) infection causes insulin resistance and diabetes as extrahepatic manifestations. We aimed to analyze the effect of HCV eradication by direct-acting antiviral (DAA) agents on glucose tolerance.

The hemoglobin A1c (HbA1c) of 272 patients with HCV infection who achieved a sustained virologic response (SVR) was analyzed at baseline before DAA treatment, at the end of DAA therapy (ETR), and 12 weeks after therapy (Post12W).

There were no significant differences in HbA1c between baseline, ETR, and Post12W in the overall patients. When the data were stratified according to the presence or absence of diabetes, median HbA1c significantly decreased from baseline (7.2%) to ETR (6.8%) and Post12W (6.8%) in the 55 patients with diabetes, whereas there were no significant changes in the patients without diabetes. Basal HbA1c, fasting plasma glucose, and age were independently associated with the changes in HbA1c according to multivariate analysis, and the predictive formula for changes in HbA1c was found to be ΔHbA1c (%) = 1.449-0.4* HbA1c (%) + 0.012 × Age (year). There were no changes in body mass in diabetic or nondiabetic patients. In diabetic patients taking medication, 63.4% of patients needed less medication.

Eradication of HCV improves glycemic control, indicated by a 0.4% decrease in HbA1c in diabetes.
Eradication of HCV improves glycemic control, indicated by a 0.4% decrease in HbA1c in diabetes.
Sodium glucose cotransporter 2 inhibitors (SGLT-2i), by way of their unique mode of action, present an attractive strategy for the treatment of type 2 diabetes and non-alcoholic fatty liver disease (NAFLD), which often coexist and may lead to severe complications. Roxadustat HIF modulator However, the evidence for treatment with SGLT-2i is limited to small heterogeneous studies. Therefore, this meta-analysis was conducted to deduce the effects of SGLT-2i in NAFLD with type 2 diabetes (T2D).

A web-based search identified nine randomized controlled trials from the Cochrane Library, Embase, and PubMed for this meta-analysis. The Comprehensive Meta-Analysis Software version 3 was used to calculate the effect size.

The outcomes of interest were analyzed from a pooled population of 11 369 patients-7281 on SGLT-2i and 4088 in the control arm. SGLT-2i therapy produced a statistically significant improvement in alanine aminotransferase [standardised mean difference (SDM), -0.21, 95% confidence interval (CI), -0.32 to -0.10,
< 0.01], aspartate aminotransferase (Standardised mean difference (SDM), -0.15, 95% CI, -0.24 to -0.07,
< 0.01), and liver fat as measured by proton density fat fraction (SDM, -0.98, 95% CI, -1.53 to -0.44,
< 0.01) in comparison to standard of care or placebo. In addition, there was a significant reduction in glycosylated hemoglobin (SDM, -0.37, 95% CI, -0.60 to -0.14,
< 0.01) and weight (SDM, -0.58, 95% CI, -0.93 to -0.23,
< 0.01) in the SGLT-2i arm.

This meta-analysis provides a convincing signal that SGLT-2i have a salutary effect on NAFLD in type 2 diabetes (T2D), probably driven by an improvement of glycemia and body weight, which in turn attenuates hepatic inflammation and hepatic fat accumulation.
This meta-analysis provides a convincing signal that SGLT-2i have a salutary effect on NAFLD in type 2 diabetes (T2D), probably driven by an improvement of glycemia and body weight, which in turn attenuates hepatic inflammation and hepatic fat accumulation.
Patients with chronic liver disease (CLD) are at high risk of infections, including fungal pathogens, which can lead to hepatic encephalopathy (HE) and increased mortality. Our aim is to evaluate the frequency and outcome of fungal urinary tract infections (FUTIs) in hospitalized patients with CLD and HE.

This was a descriptive case series study using the nonprobability consecutive sampling technique, conducted at the Department of Gastroenterology, Liaquat National Hospital, Karachi, Pakistan. All patients above 18 years of age who were admitted with HE and CLD were enrolled after obtaining informed consent. Baseline laboratory investigation, urine detail report (UDR), and culture were sent on the day of admission. Fluconazole was started if the UDR reported yeast positivity. Data were analyzed using SPSS version 25.

A total of 236 patients were enrolled in this study. Mean age was 53.42 ± 5.567 years, and 95 (40.3%) were male. Urinary symptoms were present in 72 (30.5%) patients. Yeast positivity on UDR was present in 156 (66.1%), and 141 of 156 (90.3%) patients had urine culture positivity for fungal pathogen. A total of 55 patients died-36 (65.5%) in the FUTI group and 19 (34.5%) in the nonfungal UTI (NFUTI) group (
= 0.908).
was the most common organism, present in 70 of 141 (49.6%) of patients. Predictors of mortality were renal insufficiency, hyperkalemia, hyponatremia, leukopenia, and advanced cirrhosis.

FUTI in CLD patients with HE is common in hospitalized patients even without symptoms, and a high index of suspicion is required.
was the most common organism. Prompt recognition and treatment can improve overall outcome.
FUTI in CLD patients with HE is common in hospitalized patients even without symptoms, and a high index of suspicion is required. Candida albicans was the most common organism. Prompt recognition and treatment can improve overall outcome.
Because covert hepatic encephalopathy (CHE) has been shown to affect the prognosis of cirrhotic patients, early diagnosis of hepatic encephalopathy (HE) is a prerequisite for the preservation of patients' quality of life and for prophylaxis of overt HE. The aim of this study was to identify a clinical parameter to predict impairment of cognitive function in cirrhotic patients with early-stage HE.

We investigated the data from 172 patients with cirrhotic or idiopathic portosystemic shunt (PSS) in phase II/III trials of rifaximin in Japan. Classification and regression trees (CARTs) were constructed to identify clinical profiles related to cognitive dysfunction as indicated by the prolongation of time required for the Number Connection Test (NCT-B).

CART analysis detected age 65 years as the variable for the initial split, and serum albumin level was selected as the variable for the second split among patients aged ≤65 years. In 27 cirrhotic patients aged ≤65 years without PSS, receiver operating characteristic curve analysis revealed that the optimal albumin level cutoff point was 3.
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