Notes

Self-activated Rh-Zr combined oxide like a nonhazardous cocatalyst for photocatalytic hydrogen advancement.
Luciferase assay illustrated LDHA, a glycolysis enzyme, was the direct target of miR-34a. Importantly, inhibiting SNHG7 successfully suppressed LDHA expressions and sensitized cisplatin resistant cells and such inhibitory effects could be recovered by further anti-miR-34a. These findings suggest an important regulator mechanism for the SNHG7-mediated cisplatin resistance via miR-34a/LDHA-glycolysis axis.Bilateral ectopic axillary breast carcinoma is extremely rare. Here, we report the case of a 68-year-old woman who presented with a palpable mass in the right axilla. After ectopic breast carcinoma diagnosis, the patient underwent partial mastectomy and sentinel lymph node biopsy, followed by radiotherapy of the whole breast. Adjuvant endocrine therapy was administered for 5 years. Seven years after the first carcinoma diagnosis, the patient noticed a second tumor in the left axilla by herself at the age of 75 years. Vismodegib Core needle biopsy revealed second primary breast carcinoma of the axilla. She underwent partial mastectomy and sentinel lymph node biopsy followed by chemotherapy, radiotherapy, and endocrine therapy. No recurrence has been observed so far. Therefore, ectopic breast carcinoma should be treated as typical breast carcinoma.
This retrospective study is designed to develop a Radiomics-based strategy for preoperatively predicting lymph node (LN) status in the resectable pancreatic ductal adenocarcinoma (PDAC) patients.

Eighty-five patients with histopathological confirmed PDAC are included, of which 35 are LN metastasis positive and 50 are LN metastasis negative. Initially, 1,124 radiomics features are computed from CT images of each patient. After a series of feature selection, a Radiomics logistic regression (LOG) model is developed. Subsequently, the predictive efficiency of the model is validated using a leave-one-out cross-validation method. The model performance is evaluated on discrimination and compared with the conventional CT evaluation method based on subjective CT image features.

Radiomics LOG model is developed based on eight most related radiomics features. Remarkable differences are demonstrated between patients with LN metastasis positive and LN metastasis negative in Radiomics LOG scores namely, 0.535±1.307 (mean±standard deviation) vs. -1.514±1.800 (mean±standard deviation) with p < 0.001. Radiomics LOG model shows significantly higher predictive efficiency compared to the conventional evaluation method of LN status in which areas under ROC curves are AUC = 0.841 with 95% confidence interval (CI 0.758∼0.925) vs. AUC = 0.682 with (95% CI 0.566∼0.798). Leave-one-out cross validation indicates that the Radiomics LOG model correctly classifies 70.3% cases, while the conventional CT evaluation method only correctly classifies 57.0% cases.

A radiomics-based strategy provides an individualized LN status evaluation in PDAC patients, which may help clinicians implement an optimal personalized patient treatment.
A radiomics-based strategy provides an individualized LN status evaluation in PDAC patients, which may help clinicians implement an optimal personalized patient treatment.
While research indicates that people with serious mental health conditions want to work, few studies have examined motivation and concerns associated with employment.

This study examined the work attitudes among two samples of Irish people with psychotic conditions, primarily schizophrenia.

Data gathered through two work related research projects was used. A self-report instrument, the work motivation scale (WMS), gathered data in two separate studies. It was possible to examine participants' motives and concerns due to the two factor structure, positive and negative, of this scale. Descriptive statistical analysis was conducted for each of the two samples individually. A sub-analysis by gender was also conducted.

Across the two samples, analysis showed the consistent motivators were increased coping ability, improved self-identity, and enhanced self-worth. Men particularly wanted others to see them as good workers. On the other hand, women regarded a job as a means to forget about having a mental illness. A sizeable minority in both samples expressed apprehensions such as work being boring and an expectation from others that they should work rather than them being personally motivated to do so.

While caution must be exercised in interpreting the results due to the small sample size, this study has extended our understanding in this under-researched but important topic.
While caution must be exercised in interpreting the results due to the small sample size, this study has extended our understanding in this under-researched but important topic.
Entrepreneurs may have to deal with different psychosocial risk factors than employees. Understanding relevant psychosocial risk factors for entrepreneurs is important for occupational health practice to develop effective measures to prevent work disability. This knowledge will be used to adjust the Work and Wellbeing Inventory an existing screening tool for employees.

The aim was to explore psychosocial risk factors and relevant personality traits to adjust and further develop the Work and Wellbeing Inventory to predict work disability for entrepreneurs.

In a qualitative explorative study, we interviewed 17 entrepreneurs varying in type of business and demographic background. By semi-structured face-to-face interviews, we explored their experiences with psychosocial risk factors related to entrepreneurship. Transcripts were analyzed by qualitatively coding procedures and constant comparative methods.

According to these entrepreneurs financial insecurity, conflict of interest, large responsibility, high number of working hours, managing tasks, and administrative burden were the major themes they had to deal with. Relevant personality traits for successful entrepreneurship were stress resistance, being all round, flexible, a good communicator, good leadership, and being able to set limits.

The results of this study are relevant for occupational health practice focusing on the wellbeing of entrepreneurs, and will be used to adjust items in the Work and Wellbeing Inventory.
The results of this study are relevant for occupational health practice focusing on the wellbeing of entrepreneurs, and will be used to adjust items in the Work and Wellbeing Inventory.
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