Notes

Flexible visible as well as short-wave infra-red camouflage employing a dynamically tunable metasurface.
93. The experimental results were in good accordance with the ones calculated from the models. Stability of the analytes in standard solutions and processed plant samples was found acceptable up to 14 days of storage at 4 °C. The validation proved also good linearity (r > 0.99995), precision (RSD less then 4 %), accuracy (96.8-99.2 %), and sensitivity (LOQs 0.14-0.61 ng; LODs 0.05-0.20 ng) of the method, and its applicability for quantification of six primary coumarins and flavan-3-ols in A. hippocastanum bark was demonstrated for real commercial samples (different providers and years of collection). selleck compound Additionally, the good separation of the plant matrix allowed for determination of the approximate contents of three minor constituents. The developed procedure proved to be a useful tool in quality control of the herbal material, and MS Excel software was demonstrated to be valuable for optimization of Derringer's function and visualization of the modelled separation.Peptide drugs are essential components of the pharmaceutical industry with a multiplicity of therapeutic properties, such as being anti-hypertensive, anti-microbial, anti-diabetic, and having anti-cancer potential. These molecules are similar in physiological structure and function to the body's endogenous signalling molecules and are therefore ideal candidates for the development of the next-generation of drugs. However, the purification of these peptides can be problematic due to poor solubility and stability, which often results in low peptide yields. Peptides are traditionally purified via RP-HPLC methods, which are tedious and employ harsh solvents that generate harmful waste to the environment. There is a growing need for more cost-effective and sustainable purification methods of these biologics. SFC can provide a greener peptide purification approach with more environmentally friendly mobile phases such as CO2 and methanol, which can easily be recycled with minimal environmental impact. Currently, there is limited knowledge regarding the SFC purification of peptides. Herein, this study investigated SFC methods to purify a tetrapeptide (LYLV), octapeptide (DRVYIHPF), and nonapeptide (LYLVCGERG) on commercially available columns at an analytical scale. The 2-ethyl pyridine column proved to be optimal based on its reproducibility, peak shapes, efficient separations, and retention factors with peptide recoveries ranging from 80 to 102%. The run times were reduced to 13 min, as opposed to the traditional RP-HPLC methods of 50 min, thus making this SFC method an efficient, greener, and more cost-effective approach for the purification of these peptides.Bisphosphonates (BPs) have broad medical applications against osteoporosis, bone metastasis and Paget's disease. The BP-related jaw osteonecrosis limits their use extensively and has a causal relationship with the process of drug disposition, such as deposition on bone and slow elimination rate. Thus it is imperative to accurately determine BP levels in either clinical or pharmacological/toxicological studies. The ability of trimethylsilyl diazomethane (TMSD) to alkylate the hydroxyls in phosphoric groups is an advantage in terms of decreasing polarity and enhancing mass response of BPs. There are, however, practical limitations to the cumbersome sample preparation procedure, the prolonged reaction time, the by-products and the obstacle to ionization. To overcome these disadvantages, a simplified and rapid precolumn derivatization method with N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide (MTBSTFA) to quantify etidronate, clodronate, alendronate and zoledronate BPs in rat plasma was established in thte in rats. Moreover, it is a promising approach for the determination of other phosphoric acid-containing metabolites.
Weaning from mechanical ventilation is a key component of intensive care treatment; however, this process may be prolonged as some patients require care at specialised centres. Current data indicate that weaning from invasive mechanical ventilation is successful in approximately 65% of patients; however, data on long-term survival after discharge from a weaning centre are limited.

We analysed predictors of survival among 597 patients (392 men, mean age 68±11) post-discharge from a specialised German weaning centre.

Complete weaning from mechanical ventilation was achieved in 407 (57.8%) patients, and 106 patients (15.1%) were discharged with non-invasive ventilation; thus, prolonged weaning was successful in 72.9% of the patients. The one-year and five-year survival rates post-discharge were 66.5% and 37.1%, respectively. Age, duration of mechanical ventilation, certain clusters of comorbidities, and discharged with mechanical ventilation significantly influenced survival (p<.001). Completely weaned patients who were discharged with a tracheostomy had a significantly reduced survival rate than did those who were completely weaned and discharged with a closed tracheostomy (p=.004).

The identified predictors of survival after prolonged weaning could support therapeutic strategies during patients' intensive care unit stay. Patients should be closely monitored after discharge from a weaning centre.
The identified predictors of survival after prolonged weaning could support therapeutic strategies during patients' intensive care unit stay. Patients should be closely monitored after discharge from a weaning centre.
Perceived Honorary Authors (PHAs) are defined as authors on manuscripts who did not contribute enough. The association between PHAs and publication chance in journals is unknown. As a start, our aim was to examine the prevalence of PHAs in the Journal of Critical Care (JCC). Furthermore, we investigated whether PHAs influences publication chance in the JCC. Also, we attempt to replicate factors associated with the prevalence of PHAs found in earlier studies.

Between January 2018 and March 2019, we invited 1310 corresponding authors of submissions after the final editorial decision to complete a survey. Descriptive statistics and multinomial and binary logistic regressions were used in data analysis.

Among the 475 respondents (response rate 36%), we found a prevalence of PHAs of 13%. There was no significant association between PHAs and editorial decisions. Furthermore, if a senior member of the department who is automatically an author was present, our multivariate analysis showed a positive association with PHAs (OR 3.
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