Notes

Determining rise in tiny lung acne nodules utilizing volumetry: comes from the "coffee-break" CT review and also ramifications regarding latest nodule operations guidelines.
3D printing provides a new approach of fabricating implantable products because it permits a flexible manner to extrude complex and customized shape of the tissue scaffolds. Compared with other printable biomaterials, the polyurethane elastomer has several merits, including excellent mechanical properties and good biocompatibility. However, some intrinsic behavior, especially high melting point and slow rate of degradation, hampered its application in 3D printed tissue engineering. Herein, we developed a 3D printable amino acid modified biodegradable waterborne polyurethane (WBPU) using a water-based green chemistry process. The flexibility of this material endows better compliance with tissue during implantation and prevents high modulus transplants from scratching surrounding tissues. The histocompatibility experiments show that the WBPU induces no apparent acute rejection or inflammatory in vivo. We successfully fabricated a highly flexible WBPU scaffold by deposition 3D printing technology at a low temperature (60~70oC), and the printed products could support the adhesion and proliferation of chondrocytes and fibroblasts. The printed blocks possessed controllable degradability due to the different amounts of hydrophilic chain extender and did not cause accumulation of acidic products. In addition, we demonstrated that our WBPU is highly applicable for implantable tissue engineering because there is no cytotoxicity during its degradation. Taken together, we envisioned that this printable WBPU can be used as an alternative biomaterial for tissue engineering with low temperature printing, biodegradability, and compatibility. © 2020 IOP Publishing Ltd.The specific recognition between DNA and single-walled carbon nanotube (SWCNT) has enabled wide applications, especially in the chiral sorting of SWCNT. However, the molecular recognition mechanism has not been fully understood. In our work, various DNA-SWCNT dispersions were prepared by ultrasonic dispersion method, and characterized by UV absorption spectroscopy, fluorescence emission spectroscopy, zeta potential measurement, SDBS exchange kinetics and computer simulation. The effect of DNA sequence on the structure and properties of hybrid molecules was analyzed. Data analysis showed that DNA with specific recognition had better dispersion quality of the corresponding SWCNT, which means that higher content of monodispersed SWCNT was obtained. The high-quality dispersion of DNA-SWCNT pair was attributed to the stronger binding between DNA and SWCNT, resulting in a tighter conformation of DNA on SWCNT surface and a larger zeta potential of DNA-SWCNT hybrids. Lithocholic acid nmr Consequently, DNA-SWCNT dispersions of recognition pair exhibited better stability against salt and stronger fluorescence emission intensity. However, the correlation between specific recognition and DNA coverage on SWCNT was not observed. This work gives more insights into the recognition mechanism between DNA and SWCNT. © 2020 IOP Publishing Ltd.OBJECTIVE Transfer function analysis (TFA) of dynamic cerebral autoregulation (dCA) requires smoothing of spectral estimates using segmentation of the data (SD). Systematic studies are required to elucidate the potential influence of SD on dCA parameters. APPROACH Healthy subjects (HS, n=237) and acute ischaemic stroke patients (AIS, n=98) were included. Cerebral blood flow velocity (CBFV, transcranial Doppler ultrasound) was recorded supine at rest with continuous arterial blood pressure (BP, Finometer) for a minimum of five minutes. TFA was performed with durations SD = 100, 50 or 25 s and 50% superposition to derive estimates of coherence, gain and phase for the BP-CBFV relationship. The autoregulation index (ARI) was estimated from the CBFV step response. Intrasubject reproducibility was expressed by the intraclass correlation coefficient (ICC). MAIN RESULTS In HS, the ARI, coherence, gain, and phase (low frequency) were influenced by SD, but in AIS, phase (very low frequency) and ARI were not affected. ICC was excellent (>0.75) for all parameters, for both HS and AIS. For SD=100s, ARI was different between HS and AIS (mean ± sdev 5.70 ± 1.61 vs 5.1 ± 2.0; p less then 0.01) and the significance of this difference was maintained for SD = 50s and 25s. Using SD = 100s as reference, the rate of misclassification, based on a threshold of ARI ≤ 4, was 6.3% for SD = 50 s and 8.1% for SD = 25 s in HS, with corresponding values of 11.7% and 8.2% in AIS patients, respectively. SIGNIFICANCE Further studies are warranted with SD values lower than the recommended standard of SD=100s, to explore possibilities of improving the reproducibility, sensitivity and prognostic value of TFA parameters used as metrics of dCA. Creative Commons Attribution license.Poly 3, 4-ethylenedioxythiophene (PEDOT) and its derivative polymers are attractive for electronic applications because of their high conductivity and circumstance stability. The fabrication of PEDOT devices generally takes a separated strategy for EDOT polymerization and then device fabrication. This makes PEDOT device fabrication complex and un-friendly for integration. For the insolubility of PEDOT in common solution, material modification including vinyl moiety group grafting on the side chain of PEDOT can be used to improve its solubility, but it will markedly reduce the conductivity. Here we report on direct laser writing of pure EDOT monomer into PEDOT with 140 nm feature size. The PEDOT nanowire possesses high conductivity of 1.28×105S/m and can be patterned on solid and flexible substrates with various structures, which paved the way towards organic high conductive device fabrication and integration. © 2020 IOP Publishing Ltd.We present the first-principles calculations under the framework of density functional theory to explore Fermi surface and electronic properties of - Covellite mineral. The correlation effects are considered applying the +U correction in the density functional theory. Lattice parameters are determined and the possibility of pressure induced phase transitions to the hypothetical B1 and B3 crystals is examined. All calculations show impending B18®B1 and B3®B1 phase transitions. Using generalized gradient approximation these are found to occur at 7.4 and 6.48 GPa, respectively. Electronic bands structures of the three crystals highlight metallic properties. Two copper atoms situated at distinct locations in covellite exhibit distinct role. The Fermi surfaces of all phases are presented. The calculations of B18 map out corrugated cylindrical Fermi surface signifying inter-layer interaction mediated by the S(II)-(S(II) bond. The +U correction shows anisotropy in the Fermi surface noted in experiment. It also indicates stronger inter-layer interaction.
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