Notes

Synthesis of 3,3-Dialkyl-Substituted Isoindolinones Empowered by Nickel-Catalyzed Reductive Dicarbofunctionalization associated with Enamides.
8% to 2.0% (lag 1d). Metal constituents such as Cu and As were associated with FEV
, FVC and PEF. The corresponding reductions in lung function parameters for an IQR increase of them ranged from 1.4% to 2.3% (lag 0 or 1d). These associations remained relatively robust after adjusting for total PM
mass and gaseous pollutants.

Our results suggest that water-soluble ions and several metal/metalloid elements might be important constituents in PM
that were associated with reduced cardiorespiratory function among COPD patients.
Our results suggest that water-soluble ions and several metal/metalloid elements might be important constituents in PM2.5 that were associated with reduced cardiorespiratory function among COPD patients.Bisphenol A (BPA) is widely used to manufacture packaging materials for various daily necessities and causes harmful effects in organs, especially liver injury, by generating oxidative stress. Oridonin, an active diterpenoid isolated from Rabdosia rubescens (Hemsl.) Hara, has been reported to possess a wide range of pharmacological activities including anti-inflammatory, antioxidative and antiapoptotic effects. However, the role of oridonin in BPA--induced liver injury and its potential protective mechanism have not been well characterized. In this research, we explored the metabolic alterations in the liver tissue of rats after exposure to BPA with or without pretreatment with oridonin for 14 days by metabolomics analysis based on UPLC-MS/MS. Rats were randomly divided into groups as follows Control, Vehicle, Oridonin (10 mg/kg), Bisphenol A (500 mg/kg), bisphenol A + Oridonin (500 + 10 mg/kg), Bisphenol A + Diammonium glycyrrhizinate (500 + 40 mg/kg). The biochemical results showed that oridonin significantevel, which might be used to identify new protective agents that prevent BPA-induced liver injury.Aniline is a toxic aromatic amine and an inhibitor of nitrification. This study explored the inhibition effect and underlying mechanism. After sludge acclimation, 540 mg/L aniline was removed in 24 h and almost all ammonia released from aniline was oxidized to nitrate. However, nitrification never started until no aniline left. The cellular adenosine triphosphate (cATP) concentration of acclimated sludge reduced only by 2% after aniline exposure. Neither transmembrane transport of ammonia nor ammonia monooxygenase (AMO) activity was affected by aniline. Growing initial aniline concentration did not deteriorate the specific nitrification rate (NR). These all revealed that the toxicity of aniline only play a minor role in inhibition. DNA Damage inhibitor Competition for dissolved oxygen (DO) was proposed to be another possible inhibition mechanism. The oxygen affinity constant (Ks) of aniline degraders and ammonia-oxidizing bacteria (AOB) was calculated to be 0.894 mg/L and 1.274 mg/L respectively, suggesting the former possessed much stronger oxygen affinity (P less then 0.01). With aniline and ammonium as initial substrates, increasing aeration intensity advanced nitrification and increased the NR. Max NR of 0.63 mgN/(gMLSS·h) was achieved at the highest aeration intensity of 1000 mL/min. This study brings one step closer to better removal of aniline and derived nitrogen pollutants.In this study, the impact of Fe2O3 nanoparticles (nFe2O3) on microbial extracellular polymeric substances (EPS) and nonylphenol (NP) degradation in sediment were investigated. The results showed that the addition of nFe2O3 lowered the degree of EPS overproduction and the amount of polysaccharides and proteins secreted in NP contaminated sediment. Particularly, the secretion of colloidal EPS (C-EPS) lowered significantly (P less then 0.05), and the content of tyrosine-like, tryptophan-like, and soluble microbial by-product-like substances in C-EPS also decreased, leading to a lower aromaticity, humification, and hydrophobicity of C-EPS. Furthermore, with lower C-EPS content in water, NP was adsorbed to sediment more easily, and the weakened toxic effect of NP to bacteria as well as a higher proportion of organic matter degrading microbes stimulated NP degradation. These findings revealed the vital role of nFe2O3 in alleviating NP toxicity to microbes and reducing NP ecological risk in aquatic environments.Halobenzoquinones (HBQs) are emerging unregulated drinking water disinfection byproducts (DBPs) that are more toxic than regulated DBPs. This study aimed to determine the distribution and formation of HBQs in drinking water from water treatment plants in China, compare their chronic cytotoxicity and their induction of chromosomal damage in Chinese hamster ovary cells, and analyze the correlation of HBQ toxicity with their physicochemical parameters. Two HBQs, 2,6-dichloro-1,4-benzoquinone (2,6-DCBQ) and 2,6-dibromo-1,4-benzoquinone (2,6-DBBQ), were detected in finished water and tap water in China. The concentrations were in the ranges of 2,3,6-trichloro-1,4-benzoquinone. The cytotoxicity of six dihalo-HBQs was negatively correlated with the octanol-water partition coefficient (r = -0.971, P less then 0.05), molar refractivity (r = -0.956, P less then 0.05), energy of the highest occupied molecular orbital (EHOMO) (r = -0.943, P less then 0.05), and polar surface area (r = -0.829, P less then 0.05). The genotoxicity of these three pairs of dihalo-HBQ isomers followed the same order as their EHOMO values. This study reveals the occurrence and formation of HBQs in drinking water in China and systematically evaluates the chromosomal damage caused by nine HBQs in mammalian cells.Concentrations of organophosphate flame retardants (OPFRs), which are used in various plastic products, were analyzed in house dust samples collected from three Korean cities (Suwon, n = 23; Jeonju, n = 20; Kunsan, n = 42). OPFRs, including tris (2-chloroethyl) phosphate (TCEP), tris (2-chloroisopropyl) phosphate (TCPP), and tris (1,3-dichloro-2-propyl) phosphate (TDCPP), were detected in 95%-100% of the samples analyzed, suggesting the widespread use of these compounds in Korea. The levels of TCEP, TCPP, and TDCPP in Suwon, Jeonju, and Kunsan ranged from the limit of quantitation to 46,000, 28,000, and 2400 ng/g, respectively. The concentrations of all OPFRs were significantly higher in house dust samples from Suwon than from Jeonju and Kunsan; this is likely due to the increased use of these compounds in Suwon, which may be associated with the number, volume, and variety of household products in homes. In Korean homes, the estimated daily intake (EDI) of OPFRs through house dust ingestion was lower than the guideline values; however, the EDI of OPFRs for toddlers was 30-fold greater than for adults, suggesting a limited risk to human health.
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