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The study of moxifloxacin-liposome complex behavior at phase transition in bilayer by DSC method revealed that in DPPC/CL2- liposomes system two microphases with different content of CL2- coexist and Mox interacts with both of these microphases resulting in the formation of two types of complexes with different structure and phase transition temperature. BL-918 in vivo This binding stabilized the gel-state of the lipid bilayer with increasing the phase transition temperature Tm up to 3-5 °C. A different situation is observed for neutral DPPC liposomes drug interaction with bilayer results in defects formation and a fluidization effect in lipid bilayer, resulted to decrease the Tm value by 2-4 °C. Moxifloxacin is not firmly binding in the membrane of DPPC and drug releases rapidly. Both embryo-derived (ESC) and induced pluripotent stem cell (iPSC) lines have been established in rabbit. They exhibit the essential characteristics of primed pluripotency. In this review, we described their characteristic features at both molecular and functional levels. We also described the attempts to reprogram rabbit pluripotent stem cells (rbPSCs) toward the naive state of pluripotency using methods established previously to capture this state in rodents and primates. In the last section, we described and discussed our current knowledge of rabbit embryo development pertaining to the mechanisms of early lineage segregation. We argued that the molecular signature of naive-state pluripotency differs between mice and rabbits. We finally discussed some of the key issues to be addressed for capturing the naive state in rbPSCs, including the generation of embryo/PSC chimeras. Phenoloxidase (PO) is a key enzyme in the melanization process involved in elimination of pathogens in insects. The PO system is rapidly activated in response to pathogen recognition. Inhibition of PO activity can be a way to avoid immune response and increase infection effectiveness. In this study, the effects of inoculation of Galleria mellonella larvae with Aspergillus niger α-1,3-glucan and conidia on PO activity in hemolymph are analyzed in comparison with the effects of β-1,3/1,6-glucan inoculation. Our results indicate that α-1,3-glucan, a fungal cell wall polysaccharide, can play a role of a virulence factor involved in inhibition of the insect PO system. Gynaikothrips uzeli gall thrips are protected from insecticide exposure by their leaf gall habitat. A biocontrol strategy based on entomopathogenic fungi is an alternative approach for the control of G. uzeli. Higher temperatures can promote the reproduction and spread of pests; however, the impact of higher temperatures on biological control is unclear. We studied the immunocompetence of thrips from different latitudes and determined the effect of degree days on thrips immunity. We examined the potential impact of temperature on the biocontrol provided by entomopathogenic fungi. Beauveria bassiana pathogenicity against thrips increased with decreasing latitude, suggesting that immunity of thrips increased as latitude increased. The phenoloxidase activity of G. uzeli increased with increasing latitude but there was no significant change in hemocyte concentration. This indicated that the humoral immunity of thrips was significantly associated with degree days, and this was confirmed by transcriptome data. Transcriptome and RT-PCR results showed that the expression of key genes in eight toll pathways increased with increasing latitude. The relative expression of key genes in the Toll pathway of thrips and the activity of phenoloxidase decreased with increasing degree days that are characteristic of lower latitudes. These changes led to a decrease in humoral immunity. The immunity of G. uzeli against entomopathogenic fungi increased as degree days characteristic of lower latitudes decreased. Increased temperatures associated with lower latitude may therefore increase biocontrol efficacy. This study clarified immune level changes and molecular mechanisms of thrips under different degree days. Bacillus thuringensis (Bt) vegetative insecticidal proteins share no sequence or structural homology with the known Cry proteins. The activity of Vip3Aa is generally considered to be restricted to lepidopteran insects. In this paper, the vip3Aa gene was cloned from Bt subsp. kurstaki HD1 and expressed in E. coli. It was found to be toxic to Aedes aegypti larvae - the first time that dipteran activity has been reported. Furthermore, the potential synergism of Vip3Aa with the Cry toxins was investigated. Although no significant synergism was observed, Vip3Aa could be used in combination with Cry toxins to prevent or delay the onset of resistance. BACKGROUND Shorter humeral stems were developed to improve bone preservation, vascularity and osteointegration in reverse total shoulder arthroplasty (RSA). While some studies examined the relationship between canal filling and radiographic changes, none evaluated the association between stem alignment and canal fill ratio (CFR). HYPOTHESIS The hypothesis was that stem misalignment after RSA would be associated with lower CFR. PATIENTS AND METHODS The authors retrospectively reviewed immediate postoperative radiographs of 157 patients, comprising 56 men (36%), who underwent RSA with a short uncemented stem with neck shaft angle (NSA) default of 145°. The parameters included postoperative NSA and metaphyseal CFR, both measured with excellent inter-observer agreement. Uni- and multivariable linear regressions were performed to determine associations between postoperative NSA and 5 variables (CFR, gender, age, BMI, and surgical approach). RESULTS Postoperative NSA was 149°±8°, exceeding 5° of varus in 15 shoulders (9%) and 5° of valgus in 60 shoulders (38%), and CFR was 58%±8%. CFR was lower in shoulders with varus stem alignment (54%±6%) than shoulders with neutral stem alignment (59%±8%, p=0.033). Multivariable regression revealed that postoperative NSA increased with age (beta 0.20; p=0.008), was higher for shoulders operated with the subscapularis- and deltoid-sparing approach (beta 3.82; p=0.040) but lower for men (beta -4.14; p=0.002). CONCLUSIONS Stem misalignment exceeded 5° in 47% of the shoulders. Women, older age, and subscapularis- and deltoid-sparing approach are associated with greater risks of valgus stem positioning, while lower CFR seems to be associated with greater risks of varus stem positioning. LEVEL OF EVIDENCE IV; case series.
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