Notes

Radiation proctitis-related lumbar spondylodiscitis on account of Actinomyces odontolyticus: a rare obtaining.
The purpose of this research was to identify predictors of pressure injury, using data from the electronic health records of critically ill adults.

A retrospective cohort study was conducted using logistic regression models to examine risk factors adjusted for age, gender, race/ethnicity and length of stay.

The study cohort included 1587 adults in intensive care units within an urban academic medical centre.

The presence or absence of a hospital-acquired pressure injury was determined during monthly skin integrity prevalence surveys. All pressure injuries were independently confirmed by two Certified Wound Care Nurses.

Eighty-one (5.1%) of the 1587 cohort patients developed pressure injuries. After adjusting for confounders, the clinical variables associated with pressure injury development included mean arterial pressure <60mmHg and lowest Total Braden score up to two weeks prior to the date of HAPI development or date of prevalence survey for the comparison group.

This study provides a more comprehensive understanding about pressure injury risk in critically ill adults, identifying extrinsic and intrinsic factors associated with pressure injury development. Prospective multisite studies are needed to further examine these potential contributors to pressure injury development within the context of adherence to prevention interventions.
This study provides a more comprehensive understanding about pressure injury risk in critically ill adults, identifying extrinsic and intrinsic factors associated with pressure injury development. Prospective multisite studies are needed to further examine these potential contributors to pressure injury development within the context of adherence to prevention interventions.
To explore critical care nurses' lived experiences of transferring intensive care patients between hospitals.

A phenomenological hermeneutic approach using data generated through individual interviews with 11 critical care registered nurses.

Two general intensive care units in Sweden.

Five themes were identified it depends on me; your care makes a difference; being exposed; depending on interprofessional relationships; and sensing professional growth. compound W13 cell line These themes were synthesised into a comprehensive understanding showing how transferring intensive care patients between hospitals meant being on an ambivalent journey together with the patient but also on a journey within yourself in your own development and growth, where you, as a nurse, constantly are torn between contradictory feelings and experiences.

Interhospital intensive care unit-to-unit transfers can be a challenging task for critical care nurses but also an important opportunity for professional growth. During the transfer, nurses become responsible for the patient, their colleagues and the entire transfer process. In a time of an increasing number of interhospital intensive care unit-to-unit transfers, this study illuminates the risk for missed nursing care, showing that the critical care nurse has an important role in protecting the patient from harm and safeguarding dignified care.
Interhospital intensive care unit-to-unit transfers can be a challenging task for critical care nurses but also an important opportunity for professional growth. During the transfer, nurses become responsible for the patient, their colleagues and the entire transfer process. In a time of an increasing number of interhospital intensive care unit-to-unit transfers, this study illuminates the risk for missed nursing care, showing that the critical care nurse has an important role in protecting the patient from harm and safeguarding dignified care.
Hydroxychloroquine (HCQ) was proposed as potential treatment for COVID-19.

We set-up a multicenter Italian collaboration to investigate the relationship between HCQ therapy and COVID-19 in-hospital mortality.

In a retrospective observational study, 3,451 unselected patients hospitalized in 33 clinical centers in Italy, from February 19, 2020 to May 23, 2020, with laboratory-confirmed SARS-CoV-2 infection, were analyzed. The primary end-point in a time-to event analysis was in-hospital death, comparing patients who received HCQ with patients who did not. We used multivariable Cox proportional-hazards regression models with inverse probability for treatment weighting by propensity scores, with the addition of subgroup analyses.

Out of 3,451 COVID-19 patients, 76.3% received HCQ. Death rates (per 1,000 person-days) for patients receiving or not HCQ were 8.9 and 15.7, respectively. After adjustment for propensity scores, we found 30% lower risk of death in patients receiving HCQ (HR=0.70; 95%CI 0.59 to 0.84; E-value=1.67). Secondary analyses yielded similar results. The inverse association of HCQ with inpatient mortality was particularly evident in patients having elevated C-reactive protein at entry.

HCQ use was associated with a 30% lower risk of death in COVID-19 hospitalized patients. Within the limits of an observational study and awaiting results from randomized controlled trials, these data do not discourage the use of HCQ in inpatients with COVID-19.
HCQ use was associated with a 30% lower risk of death in COVID-19 hospitalized patients. Within the limits of an observational study and awaiting results from randomized controlled trials, these data do not discourage the use of HCQ in inpatients with COVID-19.
To investigate the feasibility of combining coronary computed tomography (CT) angiography (CCTA) and CTA to evaluate access vessels for transcatheter aortic valve replacement (TAVR) patients in free-breathing and with single contrast medium injection using a 16-cm-wide detector CT.

One hundred and twenty-one consecutive patients (73.33 ± 6.43 years) referred for TAVR underwent a serious CT scans in free-breathing after one contrast injection ECG-triggered one-heartbeat axial CCTA, followed by non-ECG-gated neck, thoracic, and abdominal CTA. Patient weight-dependent contrast dose volume at 1.0 mL/kg was used. CT attenuation values of the coronary, neck, aortic, iliac, and femoral arteries were measured and their image quality was evaluated with a 4-point score method. Stenosis (≥50%) in CCTA was evaluated using invasive coronary angiography result as a reference standard. Radiation and contrast doses were assessed.

The total dose-length-product for the entire examination was 411.4 ± 91.2 mGy.cm, and the total contrast dose was 57.
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