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st cases. Surgical treatment has an important role in both the diagnosis and management of primary pneumococcal peritonitis, same as adequate antibiotic therapy. Primary peritonitis should be a part of the differential diagnosis of patients presenting with acute abdominal pain.The new coronavirus SARS-CoV-2 is responsible for the development of acute infectious illness named COVID-19. While most people have a mild course of the disease, a significant minority of patients will develop some degree of respiratory insufficiency requiring hospitalization. In case of failure of conventional oxygen therapy, the method of choice in patients with respiratory insufficiency is ventilation with high-flow nasal cannula (HFNC). In order to reduce the dispersion of infectious aerosol during HFNC treatment, nasal cannula is often covered with a surgical mask in many hospitals. According to recent observations, the application of a surgical mask in these patients could also have a positive effect on oxygenation parameters without clinically relevant side effects. In the present set of case reports, we demonstrate this effective, simple and affordable way how to improve oxygenation in patients with COVID-19 and hypoxemic respiratory failure treated with HFNC.Gout is a metabolically-related joint disease, characterized by recurrent episodic arthritis. The recent epidemiological study suggests that the incidence of hyperuricemia and gout in many countries has risen especially in recent decades. A possible explanation may be a decreased physical activity level and changes in eating habits. The patients lifestyle is one of the key factors contributing to the development of hyperuricemia. For patients, an important part of therapy is non-pharmacological treatment through changes in lifestyle factors such as dietary measures, weight control, and adequate hydration and exercise. Lifestyle changes can lead to beneficial health changes in patients. The relationships between serum uric acid levels, hyperuricemia, obesity, and metabolic syndrome are well established. Higher serum uric acid concentration positively correlates with body mass index (BMI) and metabolic syndrome. The reduction of BMI may lead to improved hyperuricemia in patients. Other important changes include stopping alcohol consumption, reducing the intake of sweetened beverages, increasing the intake of dairy products, no eating organ meats, sea fish, sausages. Proper hydration is also an important part of the treatment.Rheumatoid arthritis is a chronic autoimmune inflammatory disease associated with multiple metabolic alterations and increased cardiovascular risk. It is supposed that visceral obesity seems to be a connection between rheumatoid arthritis and cardiovascular diseases. Obesity is not only associated with increased disease activity and worsened quality of life in this group of patients, but also determines the effectiveness of treatment. Biological therapy interferes with metabolic changes, too. Therefore, there is a tendency to select the right anticytokine preparation in the first line of treatment to reduce not only disease activity but also affect aspects of metabolic syndrome and comorbidites, thereby reducing cardiovascular risk and patients mortality. This work offers a basic overview of the associations between rheumatoid arthritis and metabolic disorders, describes the impact of biological therapy on individual components of the metabolic syndrome.
LDL-cholesterol (LDL-C) is determined by methods whose accuracy is significantly affected in various clinical or analytical situations. Two computational methods have recently been described, the Martin equation and the Sampson equation, validity of which we compare with the Friedewald equation.
LDL-C comparisons determined by the 3 equations were performed on 4 real sets of lipid data, generated in various previous studies, ranging from n = 140 to n = 7 393. We have created an artificial set of data on the extent of 900 members with equally distributed values of TC, HDL-C and TG troughout the commonly found range. Such a data set is independent of the phrase "we performed the calculations on our file". Comparisons were also made on this artificial file.
The difference between the LDL-C values determined by the different equations gradually increases with decreasing LDL-C levels, both in the subgroup of low TG values and in the subgroups of medium and higher TG values. This applies to all 4 real files as well as to the artificial file. Cpd 20m purchase These differences are more visible the larger the file size. For the artificial set, the overall agreement between the LDL-C categories was lowest when comparing the Friedewald and Martin equations (83.1%), higher between the Sampson and Martin equations (88.9%) and highest when comparing the Friedewald and Sampson equations (90.9%). In all 4 real sets, the trends of overestimation and underestimation between the equations were exactly the same as in the artificial set.
The results of clinical and epidemiological studies are significantly influenced by the method used to determine LDL-C. When comparing the calculation methods for determining LDL-C, it is possible to preferably use the described artificial set.
The results of clinical and epidemiological studies are significantly influenced by the method used to determine LDL-C. When comparing the calculation methods for determining LDL-C, it is possible to preferably use the described artificial set.Cardiovascular diseases on an atherosclerotic basis are a serious health problem. Atherosclerosis is a multifactorial pathological process with complex pathogenesis. Its origin and development is conditioned by a set of several risk factors. Changes in the spectrum of lipoproteins are one of the well-known, serious risk factors for cardiovascular disease. The results of several authors showed, that the examination of the ratio of some lipoproteins can provide more accurate information about the cardiovascular risk in a given individual than the individual lipid parameters alone. Non-alcoholic fatty liver disease (NAFLD) is currently the most common form of chronic hepatopathy. The aim of our study was to examine lipoprotein ratios - atherogenic index of plasma (AIP) and butyrylcholinesterase/ HDL-cholesterol ratio - in patients with NAFLD and to evaluate their changes in relation to the severity of hepatic steatosis. The study group consisted of 64 patients with hepatic steatosis, 32 men and 32 women. Patients were examined for fatty liver index (FLI), with FLI values above 60.
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