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Direct comparability regarding cardiovascular magnetic resonance attribute tracking and 2D/3D echocardiography speckle monitoring for evaluation of global left ventricular tension.
A significant association was observed that high NLR and PLR predict poor overall survival and disease-free survival. Conclusions NLR and PLR can be used as available biomarkers in prognostic survival and formulation of treatment strategy of multiple cancers.Background Anemia and vitamin D deficiency are two important public health issues that may accompany many acute and chronic diseases. Several studies conducted in recent years have suggested that vitamin D deficiency is associated with anemia in healthy and patient populations. The aim of the study is to investigate the relationship between vitamin D deficiency and anemia. Methods The data of 9,590 adults aged 18 - 64, who applied for periodic medical examination to family medicine polyclinics of a training hospital between 2016 and 2018, were evaluated retrospectively. learn more Individuals were classified into three groups as iron deficiency, iron deficiency anemia, and anemia; and 25 hydroxy vitamin D (25(OH)D) levels were classified into three groups as deficiency, insufficiency, and sufficiency. The groups were compared with respect to study parameters. Results Of the participants, 2,395 were male (25.0%) (mean age = 43.75 ± 13.43) and 7,195 (75.0%) were female (mean age = 42.93 ± 12.85). The number of anemic patients was 1,470 (15.3%) while the number of patients having no symptoms of anemia was 8,120 (84.7%). Serum hemoglobin (Hgb), iron, and ferritin levels were found to be significantly lower in the group with 25(OH)D deficiency than in the group of those with no deficiency. The mean 25(OH)D levels were observed to be significantly lower in those having anemia (17.4 ng/mL) than in those who do not (20.2 ng/mL), in those having iron deficiency (18.2 ng/mL) than in those who do not (20.5 ng/mL), and in those having iron deficiency anemia (16.6 ng/mL) than in those who do not (20.1 ng/mL) (all p-values are less then 0.001). Conclusions The findings of this large study population, who live in a Mediterranean city which is sunny for 300 days of the year, indicate that 25(OH)D deficiency is significantly associated with iron deficiency and/or anemia.Background Thymidine kinase-1 (TK-1) is associated with proliferation and malignancy and has been extensively studied as a diagnostic biomarker for a variety of tumors, but there are limited data for prostate cancer. Methods TK-1 concentrations in serum were measured in 59 patients with prostate cancer (mean age 68 years) and in the control group of 28 healthy men (mean age 63 years) using commercially available enzymatic immunoassay (LSBio, Inc., Seattle, WA, USA). The patients were divided with respect to the severity of the disease into two groups according to the European Association of Urology (EAU) guidelines (Stage 1, 2 - less severe tumors, stage 3 - severe tumors). Results Serum thymidine kinase-1 concentrations were significantly elevated in the group of the patients with prostate cancer compared to the healthy individuals (0.204 pmol/L vs. 0.072 pmol/L, with p less then 0.0001). Diagnostic efficiency of serum TK-1 concentrations was 0.792 with the specificity of 53.6% and sensitivity of 94.9%. Patients with less severe tumors (Stage 1, 2) and severe tumors (Stage 3) had significantly increased levels of TK-1 as well (p less then 0.0001). Combination of TK-1 and PSA investigation in patients with PCa improve the diagnostic validity of TK-1 (AUC = 0.87). Conclusions Concentrations of thymidine kinase 1 are increased in all patients with prostate cancer and even more in patients with severe prostate cancer. Thymidine kinase 1 appears to be a promising additional diagnostic marker promising in patients with prostate cancer.Background Calprotectin is a well-established marker for intestinal inflammation, mainly in inflammatory bowel disease, and represents one of the most studied biomarkers in stool samples. Methods Apart from its important diagnostic role in inflammatory bowel disease, there are few studies showing that calprotectin can also be used as a diagnostic tool in patients suffering from hepatic encephalopathy (HE) and spontaneous bacterial peritonitis (SBP) in cirrhosis. Results Since calprotectin concentration in the human stool or in ascites is elevated at an early stage of inflammation, it might serve as an early screening tool for patients suffering from cirrhosis who are at risk to develop these conditions. As detection and monitoring of HE and SBP may be unclear and resource-intensive, identification of valid new markers of disease activity is necessary. In this review, we summarize the current knowledge of calprotectin as a diagnostic biomarker in cirrhosis, indicating that it is a highly promising diagnostic surrogate marker to screen for the presence of HE and SBP. Conclusions To screen cirrhotic patients for SBP, calprotectin should be assessed in ascitic fluid while it should be measured in feces when screening for HE. However, the value of calprotectin in managing individual patients must be considered in the specific clinical context.Background The aim was to investigate the expression of circulating RNA EIF4G2 (CircEIF4G2) in cervical cancer and its correlation with clinicopathological features. Methods Cervical tissue and peripheral blood serum samples were collected from 148 patients with cervical lesions, including 30 patients with low-grade squamous intraepithelial lesions (LSIL group), 35 patients with high squamous intraepithelial lesion (HSIL group), 28 patients with atypical squamous cells (ASC group), and 55 patients with cervical cancer (CC group). At the same time, cervical biopsy specimens and peripheral blood serum were collected from 40 healthy women (Normal group). RT-PCR was used to detect the expression of CircEIF4G2 in cervical tissues and peripheral blood of each group. Electron microscopy was used to observe the distribution of exosomes CircEIF4G2 in cervical tissues. Meanwhile, the correlation between the expression level of CircEIF4G2 and clinical pathological data of patients was analyzed. In vitro, HeLa cells and he culture medium of primary cervical epithelial cells. The process of exosomes CircEIF4G2 entering primary cervical cancer cells was observed by electron microscopy. Conclusions The increased expression of CircEIF4G2 in tissues and serum of cervical lesions may be caused by the secretion of exosomes containing CircEIF4G2 by cervical cancer cells. Therefore, CircEIF4G2 can be used as a marker for the diagnosis of cervical lesions.
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