Notes

Clostridium butyricum improves colonization proofed against Clostridioides difficile by metabolic as well as immune system modulation.
Groups were comparable except that more women received HH care. In propensity-weighted analyses, the odds of unplanned hospitalizations was reduced in the HH group by 55% (odds ratio, 0.45, 95% CI, 0.29 to 0.70;
< .001) and health care costs were 47% lower (mean cost ratio, 0.53; 95% CI, 0.39 to 0.72;
< .001) over the 30-day period. Secondary outcomes also favored HH. Total hospital stay days were reduced by 1.1 days (
= .004) and ED visits were reduced by 45% (odds ratio, 0.55; 95% CI, 0.33 to 0.92;
= .022). There was no evidence of a difference in ICU admissions (
= .972).

This oncology hospital at home program shows initial promise as a model for oncology care that may lower unplanned health care utilization and health care costs.
This oncology hospital at home program shows initial promise as a model for oncology care that may lower unplanned health care utilization and health care costs.This study examined prediction of various clinical outcomes in adolescents with borderline personality disorder (BPD) features. Of the 112 adolescents who participated at baseline, 97 were seen at 2-year follow-up, of which 49 (50.5%) had clinically improved, defined as a decrease in BPD pathology of minimum 12 points on the Borderline Personality Features Scale for Children (BPFS-C). Selleckchem Panobinostat Eighty-one adolescents fulfilled the diagnostic criteria for BPD and scored above clinical cutoff on the BPFS-C at baseline, of which 26 (32%) had remitted at follow-up by self-report on the BPFS-C. Results showed that adolescents with comorbid oppositional defiant disorder at baseline were less likely to have clinically improved or remitted at follow-up. Participants with increased self-reported depression and less exposure to physical abuse at baseline had increased odds of remission. Our findings suggest that more internalizing and less externalizing symptoms increase the odds of positive treatment outcome in adolescents with BPD.Within the European Research Network on BPD (EURNET-BPD; n = 85 BPD adolescents, n = 84 healthy controls, aged 13-19), this study explored the combination of three types of adversity-maltreatment, stressful life events (early separation from parents, parental suicide attempt, parental chronic disease) and parental bonding-as predictors of BPD, on a criteria-based approach. Results indicated that cumulative traumatic experiences largely characterize borderline adolescent's history; and, in the multivariate regression models, all adversity experiences were likely to contribute to BPD symptoms. The role of emotional abuse, parental suicide attempt, and a decrease in paternal level of care were particularly prominent. Moreover, adversities combinations were different for each criterion, suggesting that specific sets of traumatic experiences are leading to BPD. These findings argue for a further criteria-based exploration of trauma in borderline patients, as well as a more accurate and efficient prevention.The broad dimension of empathy has been shown to underlie various forms of psychopathology, most extensively studied for the externalizing spectrum of psychopathology. However, associations between subdimensions of empathy and functions of aggression remain unclear. The current study (N = 409) aimed to investigate common and specific associations between a higher-order model of aggression, comprising reactive aggression (RA) and proactive aggression (PA) factors with an overarching general aggression factor, and item-level factor analytically derived dimensions of empathy affective/self-oriented empathy and cognitive/other-oriented empathy. Results demonstrated specific and opposing associations between dimensions of empathy and the general aggression factor, such that affective/self-oriented empathy was positively associated, and cognitive/other-oriented empathy was negatively associated with general aggression. Affective/self-oriented empathy was positively associated with RA, whereas cognitive/other-oriented empathy was negatively associated with RA and PA. Results confirm the importance of considering the multidimensionality of empathy and aggression and suggest both common and distinct pathways from empathy to aggression.Substance use disorders (SUDs) and borderline personality disorder (BPD) are highly comorbid. In the present study, an attempt was made to understand the differences between BPD and BPD with comorbid SUD (BPD + alcohol use disorder [AUD]), by studying impulsivity and schema modes (i.e., maladaptive moment-to-moment emotional states and coping responses). BPD patients, BPD+AUD patients, and nonpatients (NP) were compared regarding behavioral impulsivity (motor impulsivity, risk taking, delay discounting), and schema modes. The two patient groups displayed greater delay discounting than the NP group. Further, BPD and BPD+AUD groups were different from the NP group regarding all schema modes investigated. However, no differences were found on any of the dependent variables between the two patient groups. It is suggested that although BPD patients are in general more impulsive and have more maladaptive moment-to-moment emotional states and coping responses, BPD patients with and without AUD seem not to be different in this respect.Personality disorder is associated with increased risk of suicidal behavior. The authors aimed to investigate the association between number of personality disorder traits and suicidality risk following sudden bereavement. A secondary analysis of cross-sectional data on 3,167 young adults in the United Kingdom who had experienced sudden bereavement investigated the association between number of traits (measured using a standardized screening instrument) and postbereavement suicide attempt and suicidal ideation. Using multivariable logistic regression, the authors found a linear relationship between number of traits and suicide attempt (adjusted odds ratio [AOR] = 1.36, 95% CI [1.23, 1.49]) and suicidal ideation (AOR = 1.31, 95% CI [1.25, 1.38]) following bereavement. This represented an increase in odds by 36% and 31%, respectively, for each additional personality trait. The authors suggest that individuals with a greater number of traits suggestive of a personality disorder diagnosis are at increased risk of suicidality after a negative life event.
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