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major CVD and mortality among patients with prior CVD but not in general populations. The consumption of fish (especially oily fish) should be evaluated in randomized trials of clinical outcomes among people with vascular disease.
Digital tomosynthesis (DTS) is currently undergoing validation for potential clinical implications. The aim of this study was to investigate the potential for DTS as a low-dose alternative to computed tomography (CT) in imaging of pulmonary pathology in patients with cystic fibrosis (CF).
DTS and CT were performed as part of the routine triannual follow-up in 31 CF patients. Extent of disease was quantified according to modality-specific scoring systems. Statistical analysis included Spearman's rank correlation coefficient (r) and Krippendorff's alpha (α).
The median effective dose was 0.14 for DTS and 2.68 for CT. Intermodality correlation was very strong for total score and the subscores regarding bronchiectasis and bronchial wall-thickening (r=0.82-0.91, P<0.01). Interobserver reliability was high for total score, bronchiectasis and mucus plugging (α=0.83-0.93) in DTS.
Chest tomosynthesis could be a low-dose alternative to CT in quantitative estimation of structural lung disease in CF.
Chest tomosynthesis could be a low-dose alternative to CT in quantitative estimation of structural lung disease in CF.The radiation protection programme is aimed at safe usage of radiation at workplace, ensuring minimum possible dose to radiation workers, patients and members of the public. Verification of the adequacy of protective measures in actual workplace is important, especially for diagnostic radiology facilities, as a substantial number of suspected overexposures are reported from these facilities. To address this issue, a study was conducted for mapping workplace radiation field at various locations in nine Diagnostic Radiology Facilities of two hospitals in India. The cumulative doses were measured for a period of 1-3 months, using personnel monitoring TLD badges. The dosemeters were placed at positions representative of two exposure situations (1) probable locations of workers during procedures, leading to genuine exposure and (2) inappropriate storage locations of personal dosemeters at user end for probing claims of nongenuine exposures. The results indicate that the measured doses at locations (1) were just a fraction of the permissible dose, provided all safety practices are adhered to. However, the measured doses at certain locations (2) exceeded the investigation levels and indicate that any inadvertent storage of the dosemeters at such locations could lead to reporting of the overexposure from these radiology facilities. Paeoniflorin supplier The outcome of the study will be useful for the investigation of such exposures and better understanding of the readout patterns of TLD badges in radiology workplaces.
It is unclear which umbilical cord management strategy is the best for preventing mortality and morbidities in preterm infants.
To systematically review and conduct a network meta-analysis comparing 4 umbilical cord management strategies for preterm infants immediate umbilical cord clamping (ICC), delayed umbilical cord clamping (DCC), umbilical cord milking (UCM), and UCM and DCC.
PubMed, Embase, CINAHL, and Cochrane CENTRAL databases were searched from inception until September 11, 2020.
Randomized clinical trials comparing different umbilical cord management strategies for preterm infants were included.
Data were extracted for bayesian random-effects meta-analysis to estimate the relative treatment effects (odds ratios [OR] and 95% credible intervals [CrI]) and surface under the cumulative ranking curve values.
The primary outcome was predischarge mortality. The secondary outcomes were intraventricular hemorrhage, severe intraventricular hemorrhage, need for packed red blood cell transfusion, aith the lower odds of mortality in preterm infants. Compared with ICC, DCC and UCM were associated with reductions in intraventricular hemorrhage and need for packed red cell transfusion. There was no significant difference between UCM and DCC for any outcome. Further studies directly comparing DCC and UCM are needed.
Compared with ICC, DCC was associated with the lower odds of mortality in preterm infants. Compared with ICC, DCC and UCM were associated with reductions in intraventricular hemorrhage and need for packed red cell transfusion. There was no significant difference between UCM and DCC for any outcome. Further studies directly comparing DCC and UCM are needed.
A combination of conservative treatments is commonly used in clinical practice for thumb base osteoarthritis despite limited evidence for this approach.
To determine the efficacy of a 6-week combination of conservative treatments compared with an education comparator.
Randomized, parallel trial with 11 allocation ratio among people aged 40 years and older with symptomatic and radiographic thumb base osteoarthritis in a community setting in Australia.
The intervention group (n = 102) received education on self-management and ergonomic principles, a base-of-thumb splint, hand exercises, and diclofenac sodium, 1%, gel. The comparator group (n = 102) received education on self-management and ergonomic principles alone. Intervention use was at participants' discretion from 6 to 12 weeks.
Hand function (Functional Index for Hand Osteoarthritis; 0-30) and pain (visual analog scale; 0-100 mm) were measured at week 6 (primary time point) and week 12. An α of .027 was used at week 6 to account for co-primary but not pain.
Australian New Zealand Clinical Trials Registry Identifier ACTRN12616000353493.
Australian New Zealand Clinical Trials Registry Identifier ACTRN12616000353493.Effective and safe treatments for Alzheimer's disease (AD) have been an elusive target for scientists who have been working tirelessly to gain control over a disease that is affecting millions of people, with continually rising case numbers as the population ages. However, in this issue of JEM, Rynearson et al. (2021. J. Exp. Med.https//doi.org/10.1084/jem.20202560) present a beacon of hope for this field with a preclinical evaluation of a potent and robust γ-secretase modulator (GSM).
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