Notes

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is located on 8p11.23 and regulates cell proliferation and survival. Increased copy number of
is found in several cancers including cancer of the breast.
is located close to
at 8p11-12 and is frequently expressed in the luminal B subtype of breast cancer. Using tissue samples from a well-described cohort of patients with breast cancer with long-term follow-up, we studied associations between
copy number in primary breast cancer tumours and axillary lymph node metastases, and proliferation status, molecular subtype and prognosis. Furthermore, we studied associations between copy number increase of
and copy number of
.

We used fluorescence in situ hybridisation for
and the chromosome 8 centromere applied to tissue microarray sections from a series of 534 breast cancer cases.

We found increased copy number (≥4) of
in 74 (13.9%) of tumours. Only 6 of the 74 cases with increased copy number were non-luminal. Increased
copy number was significantly associated with high Ki-67 status, high mitotic count and high histopathological grade, but not with prognosis. Forty-two (7.9%) cases had mean copy number ≥6. Thirty of these showed
copy number ≥6.

Our results show that
copy number increase is largely found among luminal subtypes of breast cancer, particularly luminal B (HER2
). It is frequently accompanied by increased copy number of
copy number increase is associated with high histopathological grade and high proliferation. However, we did not discover an association with prognosis.
Our results show that FGFR1 copy number increase is largely found among luminal subtypes of breast cancer, particularly luminal B (HER2-). It is frequently accompanied by increased copy number of ZNF703. FGFR1 copy number increase is associated with high histopathological grade and high proliferation. However, we did not discover an association with prognosis.Theoretical models predict that lizards adjust their body temperature through behavioral thermoregulation as a function of food availability. However, behavioral thermoregulation is also governed by interactions among physiological and ecological factors other than food availability, such as hydration state, and sometimes it can even conflict with the locomotor activity of animals. Here, we aimed to investigate the role of food intake and hydration state on behavioral thermoregulation and voluntary locomotor activity in the lizard Tropidurus catalanensis We hypothesized that food intake can influence behavioral thermoregulation via an interaction with hydration state. We also hypothesized that lizards should endeavor to spend as little time as possible to reach their preferred body temperature to defend other physiological and/or ecological functions. We collected lizards in the field and brought them to the laboratory to measure the preferred temperature selected in a thermal gradient and the total distance traveled by them in fed and unfed conditions and with variable hydration state. Our results showed that food consumption was the most important predictor of preferred temperature. In contrast, either the hydration state alone or its interaction with food consumption did not have important effects on the lizards' thermal preference. Also, we found that the total distance traveled by lizards was not affected by food intake and was barely affected by the hydration state. We provide an experimental approach and a robust analysis of the factors that influence behavioral thermoregulation and locomotor activity in a tropical lizard.Tornadoes cause damage, injury, and death when intense winds impact structures. Quantifying the strength and extent of such winds is critical to characterizing tornado hazards. Ratings of intensity and size are based nearly entirely on postevent damage surveys [R. Edwards et al., Bull. selleck chemicals llc Am. Meteorol. Soc. 94, 641-653 (2013)]. It has long been suspected that these suffer low bias [C. A. Doswell, D. W. Burgess, Mon. Weather Rev. 116, 495-501 (1988)]. Here, using mapping of low-level tornado winds in 120 tornadoes, we prove that supercell tornadoes are typically much stronger and wider than damage surveys indicate. Our results permit an accurate assessment of the distribution of tornado intensities and sizes and tornado wind hazards, based on actual wind-speed observations, and meaningful comparisons of the distribution of tornado intensities and sizes with theoretical predictions. We analyze data from Doppler On Wheels (DOW) radar measurements of 120 tornadoes at the time of peak measured intensity. In striking contrast to conventional damage-based climatologies, median tornado peak wind speeds are ∼60 m⋅s-1, capable of causing significant, Enhanced Fujita Scale (EF)-2 to -3, damage, and 20% are capable of the most intense EF-4/EF-5 damage. National Weather Service (NWS) EF/wind speed ratings are 1.2 to 1.5 categories (∼20 m⋅s-1) lower than DOW observations for tornadoes documented by both the NWS and DOWs. Median tornado diameter is 250 to 500 m, with 10 to 15% >1 km. Wind engineering tornado-hazard-model predictions and building wind resistance standards may require upward adjustment due to the increased wind-damage risk documented here.The pet trade has become a multibillion-dollar global business, with tens of millions of animals traded annually. Pets are sometimes released by their owners or escape, and can become introduced outside of their native range, threatening biodiversity, agriculture, and health. So far, a comprehensive analysis of invasive species traded as pets is lacking. Here, using a unique dataset of 7,522 traded vertebrate species, we show that invasive species are strongly overrepresented in trade across mammals, birds, reptiles, amphibians, and fish. However, it is unclear whether this occurs because, over time, pet species had more opportunities to become invasive, or because invasive species have a greater commercial success. To test this, we focused on the emergent pet trade in ants, which is too recent to be responsible for any invasions so far. Nevertheless, invasive ants were similarly overrepresented, demonstrating that the pet trade specifically favors invasive species. We show that ant species with the greatest commercial success tend to have larger spatial distributions and more generalist habitat requirements, both of which are also associated with invasiveness.
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