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Yorkshire terrier devices Ras-induced tumor progression by simply microRNA-mediated inhibition associated with cellular senescence.
Metalation of anchored porphyrins is essential for their functionality at hybrid interfaces. In this work, we have studied the anchoring and metalation of a functionalized porphyrin derivative, 5-(4-carboxyphenyl)-10,15,20-triphenylporphyrin (MCTPP), on an atomically-defined CoO(100) film under ultrahigh vacuum (UHV) conditions. We follow both the anchoring to the oxide surface and the self-metalation by surface Co 2+ ions via infrared reflection absorption spectroscopy (IRAS). At 150 K, MCTPP multilayer films adsorb molecularly on CoO(100) without anchoring to the surface. Upon heating to 200 K, the first layer of porphyrin molecules anchors via formation of a bridging surface carboxylate. Above 460 K, the MCTPP multilayer desorbs and only the anchored monolayer resides on the surface up to temperatures of 600 K approximately. The orientation of anchored MCTPP depends on the surface coverage. At low coverage, the MCTPP adopts a nearly flat-lying geometry, whereas an upright standing film is formed near the multilayer coverage. Self-metalation of MCTPP depends critically on the surface temperature, the coverage and on the molecular orientation. At 150 K, metalation is largely suppressed, while the degree of metalation increases with increasing temperature and reaches a value of around 60% in the first monolayer at 450 K. At lower coverage higher metalation fractions (85% and above) are observed, similar as for increasing temperature. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.BACKGROUND Percutaneous coronary intervention (PCI) is increasingly utilized for treatment of coronary disease involving the unprotected left main stem (ULMS). However, no studies to date have examined the outcomes of such interventions when complicated by coronary perforation (CP). METHODS Using the British Cardiovascular Intervention society (BCIS) database, data were analyzed on all ULMS-PCI procedures complicated by CP in England and Wales between 2007 and 2014. Multivariate logistic regressions were used to identify predictors of ULMS CP and to evaluate the association between this complication and outcomes. RESULTS During 10,373 ULMS-PCI procedures, CP occurred more frequently than in non-ULMS-PCI (0.9 vs. 0.4%, p  less then  .001) with a stable annual incidence. Covariates associated with CP included number of stents used, female gender, use of rotational atherectomy and chronic total occlusion (CTO) intervention. Adjusted odds of adverse outcomes for ULMS-PCI complicated by CP were higher for peri-procedural complications including cardiogenic shock, tamponade, side-branch loss, DC cardioversion, in-hospital major bleeding, transfusion requirement, and peri-procedural myocardial infarction. There were also significantly increased odds for in-hospital major adverse cardiac events (MACCE, OR 8.961, 95% CI [4.902-16.383]) and 30-day mortality (OR 5.301, 95% CI [2.741-10.251]). CONCLUSIONS CP is an infrequent event during ULMS-PCI and is predicted by female gender, rotational atherectomy, CTO interventions or number of stents used. CP was associated with significantly higher odds of mortality and morbidity, but at rates similar to previously published all-comer PCI complicated by CP. © 2020 Wiley Periodicals, Inc.PURPOSE Hydrogel spacers are a tool to improve dosimetry and overall quality of life in men receiving radiotherapy for prostate cancer. This study is a pooled analysis of a prospective cohort with long-term quality of life (QOL) follow-up data with or without hydrogel spacers to minimize the dose to adjacent organs at risk. METHODS AND MATERIALS QOL was examined using the Expanded Prostate Cancer Index Composite (EPIC) and mean changes from baseline to EPIC domains were evaluated. A total of 215 patients from a randomized multi-institutional trial of radiation with or without hydrogel spacer with a QOL end-point were pooled with 165 non-randomized patients from a single institution with prospective QOL collection in patients with or without hydrogel spacer. The proportions of men with minimally important differences (MIDs) relative to pre-treatment baseline in the bowel domain were tested using repeated measure logistic models with a pre-specified threshold for clinically significant declines (>/= 5 equivalennts (p=0.009). CONCLUSIONS In this pooled analysis of QOL after prostate radiotherapy with up to 5-years of follow-up, utilization of a rectal spacer was associated with preservation of bowel QOL. This QOL benefit was preserved with long-term follow-up. This article is protected by copyright. All rights reserved.The configuration dependent self-association mode of the two anomers of O-Ac,N -Fmoc-D-Glucosamine, a foldamer building block, leading to gel and/or single crystal formation is described. The β-anomer of the sugar amino acid ( 2 ) forms a gel from various solvents (confirmed by SEM, rheology measurements, NMR and ECD spectroscopy), while the α-anomer ( 1 ) forms none of those tested. Transition from solution state to gel is coupled to a concurrent shift of the Fmoc-groups from a freely rotating (almost symmetrical) to a specific, asymmetric orientation. While the crystal structure of the α-anomer is built as an evenly packed 3D-system, the β-anomer forms a looser superstructure of well-packed 2D-layers. Modeling indicates that in the lowest energy, but scarcely sampled conformer of the β-anomer, the Fmoc-group bends above the sugar moiety, stabilized by intramolecular CH↔π interaction between the aromatic rings. We conclude that possessing an extended and promiscuous interaction surface and a conformationally heterogeneous solution state are among the basic requirements of gel formation for a candidate molecule. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.After the first reported case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Wuhan, China, in December 2019, the contagion has spread rapidly and has become a global pandemic.1 There are as of yet no published studies beyond the case series describing the incidence and clinical course of COVID-19 in transplant recipients, a population potentially at high risk due to the ongoing immunosuppression and higher risk of comorbidities.2 This pandemic has had a major impact in transplant physicians and healthcare workers as well3 and this crisis has meant reducing or even interrupting transplant program activity, with a subsequent impact on patient morbidity and mortality that is still hard to quantify. 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