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Identification as well as surgical ligation regarding spinal CSF-venous fistula.
The efficacy of zonisamid remained over long time (more than one year) responders - 56,3%, stopping of seizures - 11% of patients. The total frequency of side-effects was similar in both groups (55,1 and 50%). The open phase did not reveal new adverse effects. Puberty and bone age did not change during one year of treatment. Zonisamid did not exert a negative effect on behavior and learning. Most of the patients and their parents evaluated the changes in the condition of the child as «marked improvement» or «very marked improvement».
Zonisamid is an effective and well-tolerated medication as add-on in treatment of partial epilepsy in children aged 6 years and older.
Zonisamid is an effective and well-tolerated medication as add-on in treatment of partial epilepsy in children aged 6 years and older.
To analyze the results of examination and treatment of patients with poststroke shoulder pain.
The study included 213 patients who have had a stroke, including 16.4% patients with poststroke shoulder pain in early recovery period and 35.9% patients with poststroke shoulder pain in late recovery period. Therapeutic efficacy of amitriptyline, lidocaine (intravenously), pregabalin, tizanidine and non-steroid anti-inflammatory drugs was assessed.
Dysfunction of nervous system plays the main role in this pain syndrome. The efficacy of the drugs in the early/late recovery period was estimated as follows nonsteroidal anti-inflammatory drugs - 33%/12%, amitriptyline - 24%/42%, gabapentin - 10%/13%, lidocaine - 95%/100%, tizanidine - 29%/33%. Seventy-six percent of patients were free of pain after treatment using a regimen suggested by the authors.
Dysfunction of nervous system plays the main role in this pain syndrome. The efficacy of the drugs in the early/late recovery period was estimated as follows nonsteroidal anti-inflammatory drugs - 33%/12%, amitriptyline - 24%/42%, gabapentin - 10%/13%, lidocaine - 95%/100%, tizanidine - 29%/33%. Seventy-six percent of patients were free of pain after treatment using a regimen suggested by the authors.Main mechanisms of action of dopamine receptor agonists, efficacy of their use according to the results of earlier clinical trials and possible side-effects are discussed. The authors present their experience of prescription of rotigotine transdermal system in an open study of 30 patients with Parkinson's disease. The duration of the study was 8 weeks. There was a significant improvement of both motor and nonmotor (pain sensations, sleep, mood). The effective dose for treatment of initial stages was 4-6 mg daily and for the full-blown stage - 6-8 mg daily. The tolerability was good.
To develop a new instrument able to identify pathological states and assess their changes during medication treatment. We aimed to study the typical practice of using alimemazine (teraligen) in patients with the diagnosis of autonomic nervous system disorder and to test the Russian version of @The Four-Dimensional Symptom Questionnaire@ (4DSQ) for measuring distress, depression, anxiety and somatization.
We examined 3053 patients (mean age 42.09 ± 11.71 years) who received teraligen in doses gradually increasing from 5 to 15 mg per day. The observational program was carried out in over 600 outpatient clinics of the Russian Federation. The 4DSQ was administered before treatment and 4 weeks after treatment. The Clinical Global Impression (CGI) scale was used before, during (after 2 weeks) and after (4 weeks) treatment with teraligen.
There was a significant improvement of patient's state assessed both by physicians (CGI scale) and by patients (96 and 98%, respectively). The 4DSQ was sensitive to the parameters of response to treatment with teraligen parameters obtained at baseline and 4 weeks after the beginning of treatment differed significantly demonstrating a significant decrease in distress, anxiety and somatization.
There was a significant improvement of patient's state assessed both by physicians (CGI scale) and by patients (96 and 98%, respectively). see more The 4DSQ was sensitive to the parameters of response to treatment with teraligen parameters obtained at baseline and 4 weeks after the beginning of treatment differed significantly demonstrating a significant decrease in distress, anxiety and somatization.
The high level of comorbidity of coronary heart disease (CHD) and depressive disorders and general aspects of their pathogenesis is an actual problem of modern research. Authors studied the content of cholesterol, platelet serotonin, platelet aggregation, activity of pro-inflammatory markers in CHD patients with comorbid depressive disorders.
The study included 76 patients with CAD. The diagnosis of depressive disorder was set according to ICD-10, The Hamilton depression scales was used.
Depressive disorders in CHD patients were associated with an increase in the activity of pro-inflammatory markers (IL-6 and TNF-α), and with high levels of low density lipoproteins. In patients with CAD and depressive disorders with high contents of platelet serotonin, the level of cholesterol was higher compared to those with low contents of serotonin. No significant differences in the functional platelet activity were identified in patients with CAD and comorbid depression compared to patients without mood disorders.
Depressive disorders in CHD patients were associated with an increase in the activity of pro-inflammatory markers (IL-6 and TNF-α), and with high levels of low density lipoproteins. In patients with CAD and depressive disorders with high contents of platelet serotonin, the level of cholesterol was higher compared to those with low contents of serotonin. No significant differences in the functional platelet activity were identified in patients with CAD and comorbid depression compared to patients without mood disorders.
To perform a psychopathological and clinical/psychological analysis of anxiety-depressive spectrum disorders (ADSD) in inflammatory otorhinolaryngological disease - larynx granuloma.
We examined 30 patients, aged 33-65 years, including 13 patients with post-surgical recurrence of granuloma and 17 patients diagnosed for the first time with granuloma.
The relationship between larynx granuloma and ADSD, predominantly of chronic type was shown. Prolonged psychotraumatic factors play a significant role in the development of ADSD. A role of anxiety in the ADSD structure as well as an importance of their diagnosis for a choice of therapeutic tactics was confirmed. Psychopharmacotherapy has led to a reduction in the frequency of granuloma relapses. The results confirmed the productivity of affective-stress model, based on the type of affectivity, in the analysis of ADSD.
The relationship between larynx granuloma and ADSD, predominantly of chronic type was shown. Prolonged psychotraumatic factors play a significant role in the development of ADSD. A role of anxiety in the ADSD structure as well as an importance of their diagnosis for a choice of therapeutic tactics was confirmed. Psychopharmacotherapy has led to a reduction in the frequency of granuloma relapses. The results confirmed the productivity of affective-stress model, based on the type of affectivity, in the analysis of ADSD.
To identify prognostic criteria of the restoration of movement in patients after acute disturbance of cerebral blood circulation.
Results of clinical examination of 82 patients after the acute disturbance of blood circulation in the left hemisphere were analyzed in the Center for Speech Pathology and Neurorehabilitation. The degree of hemiparesis was compared with disease history data, results of electroencephalography, ultrasound and transcranial dopplerography, computed tomography and biochemical study.
The volume of lesion <50 cm3 which was not located in occipital regions, the volume of lesion from 50 to 100 cm3 with the disturbance of blood circulation only in one arterial system (carotid or cerebral) and residual or moderate pathological changes in electrical activity were characteristic of favorable prognosis of rehabilitation. Poor prognosis was associated with the volume of lesion >100 cm3 with concomitant disturbance of blood circulation in two arterial systems (both carotid and cerebral), marked and moderate pathological changes in electrical activity and the occipital localization of the lesion regardless of its volume.
100 cm3 with concomitant disturbance of blood circulation in two arterial systems (both carotid and cerebral), marked and moderate pathological changes in electrical activity and the occipital localization of the lesion regardless of its volume.
To compare parameters of attention in healthy people and patients with neoplasms in different regions of the cerebral cortex and to evaluate quality of life (QoL) indices with regard to impairment of different attention systems.
Twenty patients with oncological lesions of the brain (mean age 56.5±8.8 years) who did not undergo surgery were studied. Tumor localization was confirmed using contrast-enhanced computed tomography, the tumor type was histologically verified. A control group included 18 healthy people matched for age, sex and education level. To determine attention system functions, we developed a computed version of the Attention Network Test. Error rate and reaction time for correct responses to the target stimulus, displayed along with neutral, congruent and incongruent signals, were the indicators of the efficacy of selective processes. QoL indices were assessed using SF-36 health survey questionnaire.
The readiness to respond to incoming stimuli was mostly impaired in patients with brain tdecreased while temporary parameters of the functions of this system were not changed in patients compared to controls. The SF-36 total score was stable in patients with marked reduction in scores on the Role and Emotional Functioning scales. The most severe health impairment measured on the SF-36 scales of role/social emotional functioning and viability was recorded in patients with the lesions of frontal cortical areas compared to temporal/parietal areas. The relationship between SF-36 Health self-rating and attention systems was found. This finding puts the question of the importance of attention characteristics and QoL for survival prognosis of patients with brain tumors.[Purpose] The purpose of this study is to investigate the effects of a Korean computer-based cognitive rehabilitation program (CBCR) on the cognitive function and visual perception ability of patients with acute stroke. [Subjects] The subjects were 30 patients with acute stroke. [Methods] The subjects were randomly assigned to either the experimental group (EG) or the control group (CG). The EG subjects received CBCR with the CoTras program. The CG subjects received conventional cognitive rehabilitation. All subjects participated in a standard rehabilitation program according to a daily inpatient treatment schedule. In addition to standard rehabilitation, the subjects received 20 sessions (5 days a week for 4 weeks) of CBCR or conventional cognitive rehabilitation for 30 min. To compare the two groups, the Lowenstein Occupational Therapy Cognitive Assessment (LOTCA) and Motor-free Visual Perception Test-3 (MVPT-3) were performed. [Results] Both groups showed significant improvement in LOTCA and MVPT-3. Furthermore, there were significant differences in LOTCA and MVPT-3 between the two groups.
My Website: https://www.selleckchem.com/products/kpt-9274.html
The efficacy of zonisamid remained over long time (more than one year) responders - 56,3%, stopping of seizures - 11% of patients. The total frequency of side-effects was similar in both groups (55,1 and 50%). The open phase did not reveal new adverse effects. Puberty and bone age did not change during one year of treatment. Zonisamid did not exert a negative effect on behavior and learning. Most of the patients and their parents evaluated the changes in the condition of the child as «marked improvement» or «very marked improvement».
Zonisamid is an effective and well-tolerated medication as add-on in treatment of partial epilepsy in children aged 6 years and older.
Zonisamid is an effective and well-tolerated medication as add-on in treatment of partial epilepsy in children aged 6 years and older.
To analyze the results of examination and treatment of patients with poststroke shoulder pain.
The study included 213 patients who have had a stroke, including 16.4% patients with poststroke shoulder pain in early recovery period and 35.9% patients with poststroke shoulder pain in late recovery period. Therapeutic efficacy of amitriptyline, lidocaine (intravenously), pregabalin, tizanidine and non-steroid anti-inflammatory drugs was assessed.
Dysfunction of nervous system plays the main role in this pain syndrome. The efficacy of the drugs in the early/late recovery period was estimated as follows nonsteroidal anti-inflammatory drugs - 33%/12%, amitriptyline - 24%/42%, gabapentin - 10%/13%, lidocaine - 95%/100%, tizanidine - 29%/33%. Seventy-six percent of patients were free of pain after treatment using a regimen suggested by the authors.
Dysfunction of nervous system plays the main role in this pain syndrome. The efficacy of the drugs in the early/late recovery period was estimated as follows nonsteroidal anti-inflammatory drugs - 33%/12%, amitriptyline - 24%/42%, gabapentin - 10%/13%, lidocaine - 95%/100%, tizanidine - 29%/33%. Seventy-six percent of patients were free of pain after treatment using a regimen suggested by the authors.Main mechanisms of action of dopamine receptor agonists, efficacy of their use according to the results of earlier clinical trials and possible side-effects are discussed. The authors present their experience of prescription of rotigotine transdermal system in an open study of 30 patients with Parkinson's disease. The duration of the study was 8 weeks. There was a significant improvement of both motor and nonmotor (pain sensations, sleep, mood). The effective dose for treatment of initial stages was 4-6 mg daily and for the full-blown stage - 6-8 mg daily. The tolerability was good.
To develop a new instrument able to identify pathological states and assess their changes during medication treatment. We aimed to study the typical practice of using alimemazine (teraligen) in patients with the diagnosis of autonomic nervous system disorder and to test the Russian version of @The Four-Dimensional Symptom Questionnaire@ (4DSQ) for measuring distress, depression, anxiety and somatization.
We examined 3053 patients (mean age 42.09 ± 11.71 years) who received teraligen in doses gradually increasing from 5 to 15 mg per day. The observational program was carried out in over 600 outpatient clinics of the Russian Federation. The 4DSQ was administered before treatment and 4 weeks after treatment. The Clinical Global Impression (CGI) scale was used before, during (after 2 weeks) and after (4 weeks) treatment with teraligen.
There was a significant improvement of patient's state assessed both by physicians (CGI scale) and by patients (96 and 98%, respectively). The 4DSQ was sensitive to the parameters of response to treatment with teraligen parameters obtained at baseline and 4 weeks after the beginning of treatment differed significantly demonstrating a significant decrease in distress, anxiety and somatization.
There was a significant improvement of patient's state assessed both by physicians (CGI scale) and by patients (96 and 98%, respectively). see more The 4DSQ was sensitive to the parameters of response to treatment with teraligen parameters obtained at baseline and 4 weeks after the beginning of treatment differed significantly demonstrating a significant decrease in distress, anxiety and somatization.
The high level of comorbidity of coronary heart disease (CHD) and depressive disorders and general aspects of their pathogenesis is an actual problem of modern research. Authors studied the content of cholesterol, platelet serotonin, platelet aggregation, activity of pro-inflammatory markers in CHD patients with comorbid depressive disorders.
The study included 76 patients with CAD. The diagnosis of depressive disorder was set according to ICD-10, The Hamilton depression scales was used.
Depressive disorders in CHD patients were associated with an increase in the activity of pro-inflammatory markers (IL-6 and TNF-α), and with high levels of low density lipoproteins. In patients with CAD and depressive disorders with high contents of platelet serotonin, the level of cholesterol was higher compared to those with low contents of serotonin. No significant differences in the functional platelet activity were identified in patients with CAD and comorbid depression compared to patients without mood disorders.
Depressive disorders in CHD patients were associated with an increase in the activity of pro-inflammatory markers (IL-6 and TNF-α), and with high levels of low density lipoproteins. In patients with CAD and depressive disorders with high contents of platelet serotonin, the level of cholesterol was higher compared to those with low contents of serotonin. No significant differences in the functional platelet activity were identified in patients with CAD and comorbid depression compared to patients without mood disorders.
To perform a psychopathological and clinical/psychological analysis of anxiety-depressive spectrum disorders (ADSD) in inflammatory otorhinolaryngological disease - larynx granuloma.
We examined 30 patients, aged 33-65 years, including 13 patients with post-surgical recurrence of granuloma and 17 patients diagnosed for the first time with granuloma.
The relationship between larynx granuloma and ADSD, predominantly of chronic type was shown. Prolonged psychotraumatic factors play a significant role in the development of ADSD. A role of anxiety in the ADSD structure as well as an importance of their diagnosis for a choice of therapeutic tactics was confirmed. Psychopharmacotherapy has led to a reduction in the frequency of granuloma relapses. The results confirmed the productivity of affective-stress model, based on the type of affectivity, in the analysis of ADSD.
The relationship between larynx granuloma and ADSD, predominantly of chronic type was shown. Prolonged psychotraumatic factors play a significant role in the development of ADSD. A role of anxiety in the ADSD structure as well as an importance of their diagnosis for a choice of therapeutic tactics was confirmed. Psychopharmacotherapy has led to a reduction in the frequency of granuloma relapses. The results confirmed the productivity of affective-stress model, based on the type of affectivity, in the analysis of ADSD.
To identify prognostic criteria of the restoration of movement in patients after acute disturbance of cerebral blood circulation.
Results of clinical examination of 82 patients after the acute disturbance of blood circulation in the left hemisphere were analyzed in the Center for Speech Pathology and Neurorehabilitation. The degree of hemiparesis was compared with disease history data, results of electroencephalography, ultrasound and transcranial dopplerography, computed tomography and biochemical study.
The volume of lesion <50 cm3 which was not located in occipital regions, the volume of lesion from 50 to 100 cm3 with the disturbance of blood circulation only in one arterial system (carotid or cerebral) and residual or moderate pathological changes in electrical activity were characteristic of favorable prognosis of rehabilitation. Poor prognosis was associated with the volume of lesion >100 cm3 with concomitant disturbance of blood circulation in two arterial systems (both carotid and cerebral), marked and moderate pathological changes in electrical activity and the occipital localization of the lesion regardless of its volume.
100 cm3 with concomitant disturbance of blood circulation in two arterial systems (both carotid and cerebral), marked and moderate pathological changes in electrical activity and the occipital localization of the lesion regardless of its volume.
To compare parameters of attention in healthy people and patients with neoplasms in different regions of the cerebral cortex and to evaluate quality of life (QoL) indices with regard to impairment of different attention systems.
Twenty patients with oncological lesions of the brain (mean age 56.5±8.8 years) who did not undergo surgery were studied. Tumor localization was confirmed using contrast-enhanced computed tomography, the tumor type was histologically verified. A control group included 18 healthy people matched for age, sex and education level. To determine attention system functions, we developed a computed version of the Attention Network Test. Error rate and reaction time for correct responses to the target stimulus, displayed along with neutral, congruent and incongruent signals, were the indicators of the efficacy of selective processes. QoL indices were assessed using SF-36 health survey questionnaire.
The readiness to respond to incoming stimuli was mostly impaired in patients with brain tdecreased while temporary parameters of the functions of this system were not changed in patients compared to controls. The SF-36 total score was stable in patients with marked reduction in scores on the Role and Emotional Functioning scales. The most severe health impairment measured on the SF-36 scales of role/social emotional functioning and viability was recorded in patients with the lesions of frontal cortical areas compared to temporal/parietal areas. The relationship between SF-36 Health self-rating and attention systems was found. This finding puts the question of the importance of attention characteristics and QoL for survival prognosis of patients with brain tumors.[Purpose] The purpose of this study is to investigate the effects of a Korean computer-based cognitive rehabilitation program (CBCR) on the cognitive function and visual perception ability of patients with acute stroke. [Subjects] The subjects were 30 patients with acute stroke. [Methods] The subjects were randomly assigned to either the experimental group (EG) or the control group (CG). The EG subjects received CBCR with the CoTras program. The CG subjects received conventional cognitive rehabilitation. All subjects participated in a standard rehabilitation program according to a daily inpatient treatment schedule. In addition to standard rehabilitation, the subjects received 20 sessions (5 days a week for 4 weeks) of CBCR or conventional cognitive rehabilitation for 30 min. To compare the two groups, the Lowenstein Occupational Therapy Cognitive Assessment (LOTCA) and Motor-free Visual Perception Test-3 (MVPT-3) were performed. [Results] Both groups showed significant improvement in LOTCA and MVPT-3. Furthermore, there were significant differences in LOTCA and MVPT-3 between the two groups.
My Website: https://www.selleckchem.com/products/kpt-9274.html
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