Notes

Quantification and image-derived phenotyping involving retinal ganglion cell nuclei inside the nee mouse button label of congenital glaucoma.
We sought to assess the different CT aortic root measurements and determine their relationship to transthoracic echocardiography (TTE).

TTE and ECG-gated CT images were reviewed from 70 consecutive patients (mean age 54 ± 18 years; 67% male) with tricuspid aortic roots (trileaflet aortic valves) between Nov 2009 and Dec 2013. Three CT planes (coronal, short axis en face and three-chamber) were used for measurement of nine linear dimensions. TTE aortic root dimension was measured as per guidelines from the parasternal long axis view.

All CT short axis measurements of the aortic root had excellent reproducibility (intraclass correlation coefficient, ICC 0.96-0.99), while coronal and three-chamber planes had lower reproducibility with ICC 0.90 (95% CI 0.84-0.94) and ICC 0.92 (0.87-0.95) respectively. CT coronal and short axis maximal dimensions were systematically larger than TTE (mean 2 mm larger,
< 0.001), while CT cusp to commissure measurements were systematically smaller (CT RCC-comm mean 2 mm sand the various CT measurement planes. CT coronal and short axis maximal dimensions were systematically larger than TTE, while CT cusp to commissure measurements were smaller. CT readers should indicate the plane of measurement and the specific linear dimension to avoid ambiguity in follow-up and comparison.Purpose This study investigated whether changes in brain activity preceding spoken words can be used as a neural marker of speech intention. Specifically, changes in the contingent negative variation (CNV) were examined prior to speech production in three different study designs to determine a method that maximizes signal detection in a speaking task. Method Electroencephalography data were collected in three different protocols to elicit the CNV in a spoken word task that varied the timing and type of linguistic information. The first protocol provided participants with the word to be spoken before the instruction of whether or not to speak, the second provided both the word and the instruction to speak, and the third provided the instruction to speak before the word. Participants (N = 18) were split into three groups (one for each protocol) and were instructed to either speak (Go) or refrain from speaking (NoGo) each word according to task instructions. The CNV was measured by analyzing the difference in slope between Go and NoGo trials. Results Statistically significant effects of hemispheric laterality on the CNV slope confirm the third protocol where the participants know they will speak in advance of the word, as the paradigm that reliably elicits a CNV response related to speech intention. selleck chemicals Conclusions The maximal CNV response when the instruction is known before the word indicates the neural processing measured in this protocol may reflect a generalized speech intention process in which the speech-language systems become prepared to speak and then execute production once the word information is provided. Further analysis of the optimal protocol identified in this study requires additional experimental investigation to confirm its role in eliciting an objective marker of speech intention. Supplemental Material https//doi.org/10.23641/asha.14111468.Purpose To assess the concurrent validity of two tasks used to inform diagnosis of childhood apraxia of speech (CAS), this study evaluated the agreement between the Syllable Repetition Task (SRT) and the Maximum Repetition Rate of Trisyllables (MRR-Tri). Method A retrospective analysis was conducted with 80 children 7-16 years of age who were referred for treatment studies. All children had a speech sound disorder, and all completed both the SRT and the MRR-Tri. On each task, children were classified as meeting or not meeting the tool's threshold for CAS based on the sound sequencing errors demonstrated. Results The two tasks were in agreement for 47 participants (59% of the sample); both tasks classified 13 children as meeting the threshold for CAS and 34 children as not meeting the threshold for CAS. However, the two tasks disagreed on CAS classification for 33 children (41% of the sample). Overall, the MRR-Tri identified more children as having sound sequencing errors indicative of CAS (n = 39) than did the SRT (n = 20). Conclusions These two tasks of sound sequencing differ in the children they identify with CAS, possibly due to aspects of the underlying task requirements (e.g., time pressure). The SRT and the MRR-Tri should not be used in isolation to identify CAS but may be useful as part of a balanced CAS assessment battery that includes additional tasks that inform the nature of the impairment and that aid treatment planning. Supplemental Material https//doi.org/10.23641/asha.14110280.Bryophytes occupy a basal position in the monophyletic evolution of land plants and have a life cycle in which the gametophyte generation dominates over the sporophyte generation, offering a significant advantage in conducting genetics. Owing to its low genetic redundancy and the availability of an array of versatile molecular tools, including efficient genome editing, the liverwort Marchantia polymorpha has become a model organism of choice that provides clues to the mechanisms underlying eco-evo-devo biology in plants. Recent analyses of developmental mutants have revealed that key genes in developmental processes are functionally well conserved in plants, despite their morphological differences, and that lineage-specific evolution occurred by neo/subfunctionalization of common ancestral genes. We suggest that M. polymorpha is an excellent platform to uncover the conserved and diversified mechanisms underlying land plant development.Most land plants are now known to be ancient polyploids that have rediploidized. Diploidization involves many changes in genome organization that ultimately restore bivalent chromosome pairing and disomic inheritance, and resolve dosage and other issues caused by genome duplication. In this review, we discuss the nature of polyploidy and its impact on chromosome pairing behavior. We also provide an overview of two major and largely independent processes of diploidization cytological diploidization and genic diploidization/fractionation. Finally, we compare variation in gene fractionation across land plants and highlight the differences in diploidization between plants and animals. Altogether, we demonstrate recent advancements in our understanding of variation in the patterns and processes of diploidization in land plants and provide a road map for future research to unlock the mysteries of diploidization and eukaryotic genome evolution.
Website: https://www.selleckchem.com/products/at-406.html