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Incidence associated with legacy and rising poly- as well as perfluoroalkyl substances within drinking water: In a situation examine within Tianjin (China).
© 2020 Wiley Periodicals, Inc.While several studies in adolescents have addressed issues related to romantic relationships and dating violence, there is a limited understanding of their interaction patterns. This study aims to document interactions in conflict situations by identifying profiles of adolescent romantic relationships. Qualitative analysis based on the dimensions of the Circumplex Model of Marital and Family Systems was used to investigate the interaction task of 40 dyads. A typological analysis revealed four profiles (1) rigid, (2) entangled, (3) hampered, and (4) balanced. Results highlight the diversity of romantic experiences and offer a better understanding of the intricacies of different interaction profiles. Dating violence prevention efforts and programs promoting harmonious and egalitarian romantic relationships could benefit from the insights of the identified profiles. Ivacaftor solubility dmso © 2020 Society for Research on Adolescence.BACKGROUND α-Tocopherol is a potent antioxidant present in the skin. Its concentration decreases with age. Synthetically available α-tocopherol is viscous, irritating to skin and unstable toward oxidation and ultraviolet (UV) light. AIMS To develop fatty acids based nanostructured lipid carrier (NLC) gel loaded with α-tocopherol and to evaluate its moisturizing and anti-aging properties. METHODS Lauric acid, oleic acid, and Tween-80 were used as solid lipid, liquid lipid, and surfactant, respectively. Seven formulations (F0-F6) were developed by using different concentration of ingredients. Most optimized formulation (F2) was selected for further study on the basis of characterization. Dialysis tube method was used for release study. F2 was incorporated in gel, and then, in vitro and noninvasive in vivo study regarding skin moisture content by corneometer® and skin mechanical properties by cutometer® for 12 weeks on human volunteers (n = 13) was conducted. RESULTS Size, polydispersibility index (PDI), zeta potential, and %entrapment efficiency (%EE) of optimized formulation (F2) were found 82 nm, 0.261, -28.6, and 94.88 ± 1.16, respectively. Particles were spherical in shape. The release profile showed initial burst and then sustained release, and release data were best fitted to weibull model. α-tocopherol loaded NLC gel (NLCG) appeared physically stable for 12 weeks at room temperature and showed significant results in terms of skin capacitance and mechanical properties. Rheological assessment showed non-Newtonian behavior. CONCLUSION Fatty acids based NLC proved to be a promising carrier of photochemically unstable lipophilic vitamin E with enhanced moisturizing and anti-aging properties. © 2020 Wiley Periodicals, Inc.A functional stainless steel microextraction fiber facilely prepared by in-situ growing metal-organic framework UiO-66 was presented and used for high-performance analysis of polycyclic musks. Via the robust Ag-SH bonding reaction, mercaptoacetic acid was easily anchored on Ag film to provide carboxyl group on the stainless steel fiber, then in-situ grown UiO-66 was fulfilled via the coordination reaction between Zr4+ and carboxyl group. Good characteristics including large surface area, high thermal stability and good adsorption property were achieved. Sensitive detection limits (0.015-0.04 ng·L-1 ) were achieved for polycyclic musks by coupling with GC-MS, and it could be stable enough for 150 extraction cycles without a significant loss of extraction efficiency. Compared with the classical commercial fibers, 2.2-11.4 times higher enhancement factors were shown. Applied to the analysis of fortified river water samples, five typical polycyclic musks were well detected with the recoveries of 90.2%-101.8%, respectively. It lighted a facile approach for preparing stainless steel microextraction fiber via chemically bonding in-situ grown metal-organic framework for the high-performance enrichment. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Clean energy generated from total water splitting is expected to be an affordable, sustainable, and reliable resource but it remains a challenge to gain pure fuel with a controllable pathway. Here, a simple and economical strategy that enables in situ separation of H2 /O2 product by manipulating the generated gas phases with the aid of multi-bioinspired electrodes is proposed. This versatile electrode is based on a Janus asymmetric foam with dual gradients, i.e., the wettability gradient promotes the one-way gas penetration and the geometry gradient boosts the spontaneous on-surface transport in the horizontal direction, which cooperatively facilitates self-driven 3D bubble transport in an aqueous environment. Benefitting from the 3D bionic electrode, the limited distance between the cathode and the anode can be reduced to 1 mm, and the corresponding current density is enhanced 1.5 times as compared with the common condition. This Janus triangular electrode with dual directionality elucidates 3D smart bubble manipulation during overall water splitting and should offer a great opportunity to develop advanced electrochemical processes toward complicated environments such as confined space and zero gravity. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Cardiac progenitor formation is one of the earliest committed steps of human cardiogenesis and requires the cooperation of multiple gene sets governed by developmental signaling cascades. To determine the key regulators for cardiac progenitor formation, we have developed a two-stage genome-wide CRISPR-knockout screen. We mimicked the progenitor formation process by differentiating human pluripotent stem cells (hPSCs) into cardiomyocytes, monitored by two distinct stage markers of early cardiac mesodermal formation and commitment to a multipotent heart progenitor cell fate MESP1 and ISL1, respectively. From the screen output, we compiled a list of 15 candidate genes. After validating seven of them, we identified ZIC2 as an essential gene for cardiac progenitor formation. ZIC2 is known as a master regulator of neurogenesis. hPSCs with ZIC2 mutated still express pluripotency markers. However, their ability to differentiate into cardiomyocytes was greatly attenuated. RNA-Seq profiling of the ZIC2-mutant cells revealed that the mutants switched their cell fate alternatively to the noncardiac cell lineage.
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