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Epidemic associated with Sent Aids Drug Resistance Between Recently Contaminated Individuals throughout San Diego, Los angeles 1996-2013.
AIM High-dose melphalan followed by autologous haematopoietic cell transplantation remains the standard-of-care therapy for multiple myeloma (MM). Gastrointestinal toxicity concomitant with electrolyte derangement is a primary cause of morbidity from transplant. Here, we assessed the dynamics of electrolyte imbalances and its role in hematologic counts and engraftment. Ω Patients and Methods One hundred and eighteen MM patients that received transplant were studied. RESULTS Engraftment speed (ES) was calculated as the period between the first rise in the absolute neutrophil count (ANC) and full engraftment defined as the first of three consecutive days with ANC > 500 × 106 /L. The defined median ES was 2 days (range 0-5 days) and 40 patients had ES ≤2 days. Engraftment occurred at a median of 10 days. The median time-to-nadir for phosphorus and potassium was 10 and 4.28 days, respectively. The drop in phosphorus and potassium serum level was statistically greater in patients with an ES ≤2 days compared to patients with ES ≥2 days. Magnesium level were not significantly affected and there was no significant difference between the drop in serum phosphorus and potassium based on severity of nausea or oral mucositis. CONCLUSION Our results indicate that there is a significant correlation between the magnitude of drop in potassium and phosphorous levels and a steep rise in neutrophil counts around the engraftment period following stem cell transplant. These events indicate a "genesis syndrome" characterized by a rapid, massive transfer of electrolytes into proliferating cells as has been previously described after HCT for certain high-grade lymphomas and leukemias. © 2020 Asian Pacific Society of Nephrology.The catastrophic bushfires experienced in south eastern Australia during the southern summer of 2020 have provided humanity with a timely reminder of the true horrors that can unfold in a rapidly warming world. As the need to reduce greenhouse gas emissions and offset them with carbon sequestration gains urgency, much is made of the potential for agricultural soils to act as a carbon sinks (Poulton et al. 2018). It is therefore timely that the study of Sun et al. (2020) in this issue delivers a dose of realism about the potential for conservation agriculture to sequester carbon in cropping soils across the globe, and its relationship with agricultural productivity. This article is protected by copyright. All rights reserved.We aimed to verify the expression status and diagnostic significance of IDH1 in NSCLC, especially during early stages. Serum IDH1 levels were measured by ELISA. A total of 1223 participants [660 patients with NSCLC, 276 healthy controls (HCs), 95 patients with benign pulmonary conditions (BPCs), 135 patients with other cancers (OCs) and 57 samples with interfering factors] were divided into a training cohort and a validation cohort according to three testing centers. The IDH1 concentrations in the NSCLC group were obviously higher than those in the control groups (P less then 0.001). AUCs for discriminating NSCLC patients from controls (HC, BPC and OC) were 0.870 and 0.745 (sensitivity 63.3% and 55.0%; specificity 86.8% and 86.3%) in the training cohort and validation cohort, respectively. AUCs for discriminating stage 0-IA lung cancer patients from HCs were 0.907 and 0.788 (sensitivity 58.6% and 59.1%; specificity 92.9% and 89.3%) in two cohorts, respectively. IDH1 exhibited specificity for NSCLC and had no diagnostic value for other common cancers. Furthermore, IDH1 was significantly reduced in postoperative serum. Erastin IDH1 exhibits clinical utility as a serum protein biomarker for the early diagnosis of NSCLC. This article is protected by copyright. All rights reserved.BACKGROUND Genetic sequencing and precision oncology have supported clinical breakthroughs but depend upon access to vast arrays of research specimens and data. One way for academic medical centers to fund such infrastructure and research is "commercialization" of access to specimens and data to industry. Here we explore patient and clinician perspectives regarding cancer specimen and data commercialization with the goal of improving such processes in the future. MATERIALS AND METHODS This qualitative analysis was embedded within a prospective precision oncology sequencing study of adults with head and neck cancer. Via semistructured dyadic interviews with patients with cancer and their doctors, we assessed understanding and concerns regarding potential commercialization, opinions regarding investment of profits, and perspectives regarding the return of information directly to participants from industry. RESULTS Several patient- and clinician-participants did not understand that the consent form already permi providers alike. This process will require increased transparency, comprehension, and engagement of involved stakeholders. © AlphaMed Press 2020.Metastasis is one of the most common causes of death in patients with colorectal cancer (CRC). Block of proliferation 1 (BOP1) regulates tumorigenesis, epithelial-to-mesenchymal transition, migration, metastasis, and drug resistance in several tumor types. However, the role of BOP1 in the regulation of colorectal cancer cell migration and invasion is still largely unclear. In this study, the results of immunohistochemistry showed that BOP1 was upregulated in our cohort of CRC patients. BOP1 knockdown inhibited the migration and invasion of CRC cells, confirmed by the downregulation of the mRNA levels of MMP-2 and MMP-9. The overexpression of BOP1 in CRC cells exerted the opposite effect. SP600125, an inhibitor of JNK signaling, partially abolished the BOP1 overexpression-mediated increase in the migratory and invasive ability of CRC cells. Our results indicated that BOP1 is an important regulator of CRC cell invasion and migration, predominantly through the JNK signaling pathway. © 2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc.Palliative care (PC) that has evolved from a focus on end of life care to an expanded form of holistic care at an early stage for patients with serious illnesses and their families is commonly referred to as nonhospice PC (or early PC). Patients with end stage liver disease (ESLD) suffer from a high symptom burden, deteriorated quality of life with uncertain prognosis and limited treatment options. Caregivers of these patients also bear the emotional and physical burden similar to cancer caregivers. Despite proven benefits of nonhospice PC in other serious illnesses and cancer, there are no evidence-based structures and processes to support its integration within the routine care of ESLD patients and their caregivers. In this article, we review the current state of PC within ESLD, and propose key structures and processes to integrate nonhospice PC within routine hepatology practice. Results found that PC is highly underutilized within ESLD care, and limited prospective studies are available to demonstrate methods to integrate PC within routine hepatology practices.
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