Notes

Influence involving endometriosis in obstetric final result following natural conception: a multicenter German research.
When considering mediastinal or pericardial mass, a delayed PET/CT may improve lesion-to-background contrast by reducing blood pool activity.
A 46-year-old woman presented with menorrhagia, abdominal distension, and neck mass for 3 months. Ultrasonography detected a large intra-abdominal mass and enlarged neck lymph nodes. Further 18F-FDG PET/CT scan revealed lesions with intense 18F-FDG avidity in abdominal cavity and neck. The patient underwent a biopsy of the uterine, and the diagnosis of uterine follicular dendritic cell sarcoma was finally achieved. After 6 cycles of CHOP-like chemotherapy, 18F-FDG PET/CT showed complete metabolic and morphologic resolution for follicular dendritic cell sarcoma.
A 46-year-old woman presented with menorrhagia, abdominal distension, and neck mass for 3 months. Ultrasonography detected a large intra-abdominal mass and enlarged neck lymph nodes. Further 18F-FDG PET/CT scan revealed lesions with intense 18F-FDG avidity in abdominal cavity and neck. The patient underwent a biopsy of the uterine, and the diagnosis of uterine follicular dendritic cell sarcoma was finally achieved. After 6 cycles of CHOP-like chemotherapy, 18F-FDG PET/CT showed complete metabolic and morphologic resolution for follicular dendritic cell sarcoma.
A 64-year-old man diagnosed with colon cancer underwent left hemicolectomy 1 year ago. The postoperative pathological stage was T4a N0 M0. Serial follow-up CT scans revealed a growing soft-tissue mass in the gastrosplenic ligament. FDG PET/CT was then performed for further restaging, and intense FDG uptake was observed inside the lesion, whereas no other abnormal uptake was seen. A solitary recurrence was suspected, and he underwent surgical resection. Histopathologic findings confirmed the diagnosis of chronic inflammation. This case demonstrates how a growing FDG-avid inflammatory mass of surgical site could easily be mistaken for recurrence.
A 64-year-old man diagnosed with colon cancer underwent left hemicolectomy 1 year ago. The postoperative pathological stage was T4a N0 M0. Serial follow-up CT scans revealed a growing soft-tissue mass in the gastrosplenic ligament. FDG PET/CT was then performed for further restaging, and intense FDG uptake was observed inside the lesion, whereas no other abnormal uptake was seen. A solitary recurrence was suspected, and he underwent surgical resection. Histopathologic findings confirmed the diagnosis of chronic inflammation. GDC-0994 in vitro This case demonstrates how a growing FDG-avid inflammatory mass of surgical site could easily be mistaken for recurrence.
A 50-year-old woman with a newly detected pulmonary ground-glass opacity (GGO) nodule underwent PET/CT to determine the likelihood of malignancy. This patient was enrolled in the prospective study (NCT04588064) to determine the effectiveness of 18F-FDG and 68Ga-FAPI PET/CT for characterization of the GGO nodule. On PET/CT images, minimal 18F-FDG uptake but intense 68Ga-FAPI uptake was observed in this GGO nodule. This patient subsequently underwent video-assisted thoracoscopic surgery, and postoperative pathological examination confirmed the diagnosis of invasive adenocarcinoma. This case presented an example where 68Ga-FAPI PET/CT showed higher tracer uptake than 18F-FDG in the malignant GGO nodule.
A 50-year-old woman with a newly detected pulmonary ground-glass opacity (GGO) nodule underwent PET/CT to determine the likelihood of malignancy. This patient was enrolled in the prospective study (NCT04588064) to determine the effectiveness of 18F-FDG and 68Ga-FAPI PET/CT for characterization of the GGO nodule. On PET/CT images, minimal 18F-FDG uptake but intense 68Ga-FAPI uptake was observed in this GGO nodule. This patient subsequently underwent video-assisted thoracoscopic surgery, and postoperative pathological examination confirmed the diagnosis of invasive adenocarcinoma. This case presented an example where 68Ga-FAPI PET/CT showed higher tracer uptake than 18F-FDG in the malignant GGO nodule.
Recognition of the pattern of FDG uptake in hypermetabolic axillary lymph nodes (HALs) and association with recent messenger RNA (mRNA) vaccination are important to prevent patient anxiety and further needless examinations or costly biopsies in cancer patients.

This study was a retrospective cohort study in a single tertiary care institution. We investigate the occurrence and pattern of HAL on FDG PET/CT scans from 650 consecutive cancer patients with recent BNT162b2 mRNA COVID-19 vaccination.

Between December 20, 2020, and February 8, 2021, 650 patients (351 female patients [54%]; mean age, 68.9 years) had recent mRNA COVID-19 vaccination and an FDG PET/CT scan. HALs were found in 57 (14.5%) of 394 patients (95% confidence interval [CI], 10.9%-18.7%) 12.3 ± 5.9 (1-22) days after dose 1 and in 111 (43.3%) of 256 patients (95% CI, 35.3%-52.2%; P < 0.0001) after 7.5 ± 5.4 (1-22) days after dose 2. There was no difference between dose 1 and dose 2 concerning SUVmax (3.7 ± 1.8 [1.3-11.3] and 4.5 ± 3.9 [1.4-26.3], P = 0.13, respectively), SUVmean (2.1 ± 1.0 [0.7-6.5] and 2.7 ± 2.4 [0.8-17], P = 0.08, respectively), and reactogenicity volume (2.7 ± 2.3 [0.2-11.6] cm3 and 2.7 ± 2.4 [0.2-15.5] cm3, P = 0.98, respectively). There was no difference in number and in size of positive lymph nodes between dose 1 and dose 2 3.2 ± 2.2 (1-10) and 3.7 ± 2.4 (1-12) (P = 0.18), and 1.4 ± 0.4 cm (0.7-2.5 cm) and 1.5 ± 0.4 cm (0.6-3.2 cm) (P = 0.75), respectively.

A cluster pattern of hypermetabolic ipsilateral small axillary lymph nodes is common after mRNA COVID-19 vaccination, mainly after the second injection.
A cluster pattern of hypermetabolic ipsilateral small axillary lymph nodes is common after mRNA COVID-19 vaccination, mainly after the second injection.
This pilot study tested the principle that 177Lu-DOTATATE may be applied to patients with high-grade gliomas (HGGs) that are either inoperable or refractory to the standard conventional treatments and also assessed whether this approach could be a viable therapeutic plan in this dilemma.

In this prospective study, 16 subjects experiencing HGGs that were either inoperable or refractory to the standard conventional treatments were included. All the patients checked for somatostatin receptor expression on the tumors. The patients were treated with 1 to 4 cycles of IV 177Lu-DOTATATE. The primary end point was radiological response after peptide receptor radionuclide therapy, and the secondary end point was improved quality of life using Karnofsky Performance Score and Eastern Cooperative Oncology Group score.

In total, 16 subjects (10 males and 6 females) with a mean age of 55.68 ± 13.17 years (26-73 years) participated in the study. Of them, 8 patients were new HGG cases, and 8 patients had recurrent tumors.
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