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Disordered Consuming Behaviours in Young Those that have Idiopathic Intracranial High blood pressure.
Efficient antibacterial therapy holds great promise for human health. However, it is often limited by the insufficient activity of antibacterial agents. Herein, we demonstrate that the localized surface plasmon resonance (LSPR) excitation of gold nanostars (AuNSs) can dramatically improve the antibacterial activity of a Zn-metal-organic frameworks (Zn-MOFs) nanosheet, which exhibits higher ability to generate reactive oxygen species (ROS) (∼2.5-fold) for bacterial inactivation under light irradiation. Mechanistic investigations demonstrate that the enhancement is closely related to a plasmon-induced "dual excited synergistic effect". On the one hand, the Zn-MOFs nanosheets as photosensitive agents can be excited to generate ROS with bacterial toxicity. More importantly, abundant plasmonic hot electrons are generated on the surface of AuNSs upon LSPR excitation, which are then transferred from AuNSs into the Zn-MOFs due to the energy matching. As a result, the Zn-MOFs nanosheet presents an electron-rich condition, which activates the adsorbed O2 molecule into a transition state followed by its decomposition into ROS for bacterial inactivation. This study highlights the superiority of LSPR excitation on improving the antibacterial activity of MOFs and provides a novel strategy for effective antibacterial therapy.Plasmonic hybrid catalysts have attracted great interest for the reduction of nitrobenzene waste to valuable aminobenzene, because they can use renewable solar energy to accelerate the catalytic reaction. However, the economical synthesis of non-precious plasmonic hybrid catalysts remains a big challenge. Herein we report the synthesis of plasmonic MoO2-embedded MoNi4 nanosheets (MoNi4-MoO2) by thermal annealing of NiMoO4 at 600 °C under a hydrogen atmosphere. this website The MoNi4-MoO2 hybrid catalysts retain strong plasmon absorption from MoO2 and demonstrate good catalytic activity from MoNi4 for 4-nitrophenol reduction in the dark. Under visible light irradiation, the excitation of MoO2 plasmon promotes the catalytic reaction further due to hot electron-induced increase of catalytic activity of MoNi4. In addition, the hybrid catalysts are relatively stable even under illumination reaction conditions.[This corrects the article DOI 10.1371/journal.pone.0249661.].
Older adults with chronic conditions are at high risk of complications from influenza and pneumococcal infections. Evidence about factors associated with influenza and pneumococcal vaccination among older multimorbid persons in Europe is limited. The aim of this study was to investigate the prevalence and determinants of these vaccinations in this population.

Multimorbid patients aged ≥70 years with polypharmacy were enrolled in 4 European centers in Switzerland, Belgium, the Netherlands, and Ireland. Data on vaccinations, demographics, health care contacts, and comorbidities were obtained from self-report, general practitioners and medical records. The association of comorbidities or medical contacts with vaccination status was assessed using multivariable adjusted log-binomial regression models.

Among 1956 participants with available influenza vaccination data (median age 79 years, 45% women), 1314 (67%) received an influenza vaccination within the last year. Of 1400 patients with available pneumococcspecially outpatient medical visits. Hospitalization may be an opportunity to promote vaccination, particularly targeting patients with few outpatient physician contacts.
Uptake of influenza and particularly of pneumococcal vaccination in this population of European multimorbid older inpatients remains insufficient and is determined by comorbidities and number and type of health care contacts, especially outpatient medical visits. Hospitalization may be an opportunity to promote vaccination, particularly targeting patients with few outpatient physician contacts.
Overweight and obesity impose a significant health burden in Australia, predominantly the middle-aged and older adults. Studies of the association between obesity and chronic diseases are primarily based on cross-sectional data, which is insufficient to deduce a temporal relationship. Using nationally representative panel data, this study aims to investigate whether obesity is a significant risk factor for type 2 diabetes, heart diseases, asthma, arthritis, and depression in Australian middle-aged and older adults.

Longitudinal data comprising three waves (waves 9, 13 and 17) of the Household, Income and Labour Dynamics in Australia (HILDA) survey were used in this study. This study fitted longitudinal random-effect logistic regression models to estimate the between-person differences in the association between obesity and chronic diseases.

The findings indicated that obesity was associated with a higher prevalence of chronic diseases among Australian middle-aged and older adults. Obese adults (Body Masssive weight is strongly associated with a higher incidence of chronic disease in Australian middle-aged and older adults. This finding has clear public health implications. Health promotion programs and strategies would be helpful to meet the challenge of excessive weight gain and thus contribute to the prevention of chronic diseases.One of the major risk factors for head and neck squamous cell carcinoma (HNSCC) is tobacco smoke exposure, but the mechanisms that can account for disease development remain to be fully defined. Utilizing our HNSCC mouse model, we analyzed oral squamous cell carcinomas (OSCC) induced by the active metabolite of a common smoke constituent, dibenzo[a,l]pyrene diol-epoxide (DBPDE). Analyzing protein expression by either immunofluorescence or immunohistochemistry, we identified biologic processes that are dysregulated in premalignant and invasive cancer lesions induced by DBPDE. Interestingly, p120ctn expression is downregulated in both stages of the disease. In addition to decreased p120ctn expression, there was also increased proliferation (as measured by Ki67), inflammation (as measured by NFkB (p65) expression), neovascularization (as measured by CD31) and recruitment of Ly6G-positive immune cells as well as strong EGFR expression. We also examined the effect of the chemopreventive agent black raspberry (BRB) on p120ctn and EGFR protein expression in DBPDE treated mice. p120ctn, but not EGFR, protein expression increased in mice treated with BRB. Our results suggest that modulation of p120ctn may, in part, account for the mechanism by which BRB inhibits DBPDE induced OSCC in mice.
The current study aimed to understand the links between social media use and alcohol consumption during the early months of the COVID-19 pandemic.

Data were from the national Understanding American Study, a probability-based Internet panel weighted to represent the U.S. population. Subjects (N = 5874; 51% female) were adults, 18 years and older, who completed a March survey (wave 1) and a follow-up survey one month later (wave 3). Analyses assessed the relationships of social media use at wave 1 with wave 3 alcohol use frequency, accounting for wave 1 alcohol use frequency and the sociodemographic characteristics of the sample. Two alcohol use change variables were also assessed as outcomes-increased and decreased alcohol use between waves. We considered the effect of work status changes (working/studying from home and job loss) as potential moderators.

Twitter and Instagram users and users of multiple social media platforms, but not Facebook users, drank more frequently at wave 3. The results were simi during the pandemic may have contributed to more frequent alcohol use for some social media users. The study of public health messaging via social media to change alcohol use behaviors during traumatic events is warranted.Prolonged driving under real conditions can entail discomfort linked to driving posture, seat design features, and road properties like whole-body vibrations (WBV). This study evaluated the effect of three different seats (S1 = soft; S2 = firm; S3 = soft with suspension system) on driver's sitting behavior and perceived discomfort on different road types in real driving conditions. Twenty-one participants drove the same 195 km itinerary alternating highway, city, country, and mountain segments. Throughout the driving sessions, Contact Pressure (CP), Contact Surface (CS), Seat Pressure Distribution Percentage (SPD%) and Repositioning Movements (RM) were recorded via two pressure mats installed on seat cushion and backrest. Moreover every 20 minutes, participants rated their whole-body and local discomfort. While the same increase in whole-body discomfort with driving time was observed for all three seats, S3 limited local perceived discomfort, especially in buttocks, thighs, neck, and upper back. The pressure profiles of the three seats were similar for CP, CS and RM on the backrest but differed on the seat cushion. The soft seats (S1 & S3) showed better pressure distribution, with lower SPD% than the firm seat (S2). All three showed highest CP and CS under the thighs. Road type also affected both CP and CS of all three seats, with significant differences appearing between early city, highway and country segments. In the light of these results, automotive manufacturers could enhance seat design for reduced driver discomfort by combining a soft seat cushion to reduce pressure peaks, a firm backrest to support the trunk, and a suspension system to minimize vibrations.This study aimed to analyze three ESBL-producing E. coli co-harboring mcr and ESBL genes from a healthy fattening pig (E. 431) and two sick pigs (ECP.81 and ECP.82) in Thailand using Whole Genome Sequencing (WGS) using either Illumina MiSeq or HiSeq PE150 platforms to determine their genome and transmissible plasmids. E. 431 carrying mcr-2.1 and mcr-3.1 belonged to serotype O142H31 with ST29 sequence type. ECP.81 and ECP.82 from sick pigs harboring mcr-1.1 and mcr-3.1 were serotype O9H9 with ST10. Two mcr-1.1 gene cassettes from ECP.81 and ECP.82 were located on IncI2 plasmid with 98% identity to plasmid pHNSHP45. The mcr-2.1-carrying contig in E. 431 showed 100% identity to plasmid pKP37-BE with the upstream flanking sequence of IS1595. All three mcr-3.1-carrying contigs contained the ΔTnAs2-mcr-3.1-dgkA core segment and had high nucleotide similarity (85-100%) to mcr-3.1-carrying plasmid, pWJ1. The mobile elements i.e. IS4321, ΔTnAs2, ISKpn40 and IS3 were identified in the flanking regions of mcr-3. Several genes conferring resistance to aminoglycosides (aac(3)-IIa, aadA1, aadA2b, aph(3'')-Ib, aph(3')-IIa and aph(6)-Id), macrolides (mdf(A)), phenicols (cmlA1), sulphonamide (sul3) and tetracycline (tet(A) and tet(M)) were located on plasmids, of which their presence was well corresponded to the host's resistance phenotype. Amino acid substitutions S83L and D87G in GyrA and S80I and E62K in ParC were observed. The blaCTX-M-14 and blaCTX-M-55 genes were identified among these isolates additionally harbored blaTEM-1B. Co-transfer of mcr-1.1/blaTEM-1B and mcr-3.1/blaCTX-M-55 was observed in ECP.81 and ECP.82 but not located on the same plasmid. The results highlighted that application of advanced innovation technology of WGS in AMR monitoring and surveillance provide comprehensive information of AMR genotype that could yield invaluable benefits to development of control and prevention strategic actions plan for AMR.
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