Notes

Will clean farmyard fertilizer introduce making it through bacterias directly into garden soil as well as trigger soil-borne microbiota?
This research aimed to develop a comprehensive evaluation of the mobile user interface abilities of the elderly so that technology can be designed to meet individualized needs. A total of 135 older adults were evaluated with the developed system, the Elderly Mobile User Interface Ability Evaluation System (EMUIAES). The prediction of age and the use of technology on elderly mobile interface usage were investigated based on the findings of the evaluation. The relationship between performance on Fitts' task and elderly mobile user interface ability (EMUIA) was also examined. The findings showed a strong effect of age on the elderly's use of mobile user interfaces. Previous experience with personal and tablet computers also contributed to the use of mobile user interfaces. In addition, this research demonstrated the application of Fitts' law to describe the elderly mobile user interface behaviors, particularly for tasks involving fast tapping and pointing. The EMUIAES can provide future researchers and designers a comprehensive tool to describe the elderly's diverse behaviors and changes in their ability to use mobile interfaces. Individualized interface designs for elderly users can be developed based on these findings to improve the elderly users' experiences of using technology.With the increase in digital communications systems and social media, there is a need for simple graphics-based ways to signal the occurrence of major disasters. We describe the development and initial usability testing of a sign to indicate that an earthquake has occurred. We involved 264 Italian adults, who completed an online survey to evaluate the evocativeness, simplicity, and universality of 16 emojis depicting earthquakes. Through a Self-Organising Map analysis we identified four similar response profiles to the evocativeness scale, differing in their mean strength. A non-metric Multidimensional Scaling suggested that evocativeness was higher for the emojis featuring a damaged building. Linear Mixed Models indicated that emojis with fabricated vs. natural structures were judged as more evocative, simpler, and more universal when characterized by danger from falling objects. In some cases, adding behavioral elements increased evocativeness. Practical implications for informing the development of a new emoji for earthquakes are discussed.
Post-transcriptional modifications of RNA constitute fundamental mechanisms of gene regulation. check details N
-methyladenosine (m
A) is critical for health and disease and is modulated by cellular stressors. However, associations between environmental exposures and m
A have not been studied in humans. We aimed to examine associations between tobacco smoking and particulate air pollution with m
A and mRNA expression levels of its reader, writer and eraser (RWE) genes in blood.

Using the Beijing Truck Driver Air Pollution Study, we investigated global m
A in RNA from peripheral blood collected from 106 human subjects in Beijing, China, in 2008. We measured m
A with nano-flow liquid chromatography-tandem mass spectrometry and investigated gene expression of six m
A RWEs with real-time-quantitative PCR. Using linear models, we examined associations with smoking status, pack-years, and smoking on day of visit in men, and with environmental tobacco smoke in nonsmokers. We also examined associations with ambient PM
d with long-term smoking, yet positively associated with short-term BC exposure. These results indicate variable m6A responses to environmental stressors, providing early evidence into the impacts of toxicants on RNA modifications and suggesting potential for m6A as a biomarker or mechanism in environmental health research.The biotransformation ability of the organism is the result of organ-specific responses. This paper presents a molecular and biochemical approach to elucidate the biotransformation mechanisms in different organs of Prochilodus lineatus induced at 6, 24, and 96 h after a benzo[a]pyrene (B[a]P) injection. The induction in cyp1a transcription showed an organ-specific intensity at every tested time time. The EROD (ethoxyresorufin-O-deethylase) activity increased rapidly (6 h) in the liver and the kidney; the gills and the brain showed an increase at 24 h; and the gills demonstrated the highest activity among all the organs tested. There was no increase in glutathione S-transferase (GST) activity or lipoperoxidation. The decreased hepatic glutathione content (GSH) may be due to its role as an antioxidant. B[a]P was detected in the bile, confirming the xenobiotic efflux from the metabolizing organs. The gills, liver, brain, and kidney of P. lineatus presented an integrated mechanism to deal with the xenobiotic biotransformation.
Reasons why pancreatic ductal adenocarcinoma (PDAC) continues to have poor survival are only partly known. No previous studies have analyzed the combined influence of KRAS mutations, persistent organic pollutants (POPs), and trace elements upon survival in PDAC or in any other human cancer.

To analyze the individual and combined influence of KRAS mutations, POPs, and trace elements upon survival from PDAC.

Incident cases of PDAC (n = 185) were prospectively identified in five hospitals in Eastern Spain in 1992-1995 and interviewed face-to-face during hospital admission. KRAS mutational status was determined from tumour tissue through polymerase chain reaction and artificial restriction fragment length polymorphism. Blood and toenail samples were obtained before treatment. Serum concentrations of POPs were analyzed by high-resolution gas chromatography with electron-capture detection. Concentrations of 12 trace elements were determined in toenail samples by inductively coupled plasma mass spectrometry. Msly considered; only treatment was independently related to survival. The lack of adverse prognostic effects of POPs and metals measured at the time of diagnosis provide scientific and clinical reassurance on the effects of such exposures upon survival of patients with PDAC. The weak association with KRAS mutations contributes to the scant knowledge on the clinical implications of a genetic alteration highly frequent in PDAC.
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