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Investigation regarding Personal digital assistant Measure Shape for the Extraction regarding Antimicrobial Peptide Attributes.
Hence, we tried to collect and revise important recent in vivo and in vitro researches about the most effective flavonoids and their main mechanisms of action in various types of cancer cells. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] is the disease with the highest mortality rate, which poses a great threat to people's lives. Cancer caused approximately 3.4 million death worldwide annually. Surgery, chemotherapy and radiotherapy are the main therapeutic methods in clinical practice. However, surgery is only suitable for patients with early-stage cancers, and chemotherapy as well as radiotherapy have various side effects, both of which limit the application of available therapeutic methods. In 1965, liposome was firstly developed to form new drug delivery systems given the unique properties of nanoparticles, such as enhanced permeability and retention effect. During the last 5 decades, liposome has been widely used for the purpose of anticancer drug delivery, and several advances have been made regarding liposomal technology, including long-circulating liposomes, active targeting liposomes and triggered release liposomes, while problems exist all along. This review introduced the advances as well as the problems during the development of liposomal nanosystems for cancer therapy in recent years. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] Breast cancer is considered as the most perilous sickness among females worldwide and the ratio of new cases is expanding yearly. Many researchers have proposed efficient algorithms to diagnose breast cancer at early stages, which have increased the efficiency and performance by utilizing the learned features of gold standard histopathological images. OBJECTIVE Most of these systems have either used traditional handcrafted features or deep features which had a lot of noise and redundancy, which ultimately decrease the performance of the system. METHODS A hybrid approach is proposed by fusing and optimizing the properties of handcrafted and deep features to classify the breast cancer images. HOG and LBP features are serially fused with pretrained models VGG19 and InceptionV3. PCR and ICR are used to evaluate the classification performance of proposed method. RESULTS The method concentrates on histopathological images to classify the breast cancer. The performance is compared with state-of-the-art techniques, where an overall patient-level accuracy of 97.2% and image-level accuracy of 96.7% is recorded. CONCLUSION The proposed hybrid method achieves the best performance as compared to previous methods and it can be used for the intelligent healthcare systems and early breast cancer detection. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] The videos produced during wireless capsule endoscopy have larger data size causing difficulty in transmission with limited bandwidth. The constraint on wireless capsule endoscopy hinders the performance of compression module. OBJECTIVES The objectives of this paper are as follows (i) to have an extensive review on the lossless compression techniques and (ii) to find out the limitations of the existing system and the possibilities for improvement. METHOD The literature review has been done with a focus on the compression schemes satisfying minimum computational complexity, less power dissipation and low memory requirements for hardware implementation. A thorough study on various lossless compression techniques is done under two perspectives, i.e., techniques applied on Bayer CFA and RGB images. The details of the various stages of wireless capsule endoscopy compression are looked into to have a better understanding. The suitable performance metrics for evaluating the compression techniques are listed from various literatures. RESULT In addition to the Gastrolab database that is widely, WEO clinical endoscopy atlas and Gastrointestinal atlas found to be better alternatives for experimentation. Pre-processing operations, especially new subsampling patterns need to be given more focus to exploit the redundancies in the images. Selleck ABBV-075 Investigations shows encoder module can be modified to bring more improvement towards compression. The real-time endoscopy still exists as a promising area for exploration. CONCLUSION This review presents a research update on the details of wireless capsule endoscopy compression together with the findings as an eye-opener and guidance for further research. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] AND OBJECTIVE The recent alarming reports relating to "opioid crisis" necessitates the development of safer and effective analgesics without unwanted side effects. Thus, there needs to be alternative target or strategy for the development of drugs for the treatment of opioid use/abuse. As one of the novel targets, in these two decades, ligands targeting opioid receptor "heteromerization" including mu opioid receptor (MOPr)-delta opioid receptor (DOPr) heteromer has been proposed and the pharmacological advancement of reduced side effects has been broadly accepted and well recognized. In this review, I will introduce some of the ligands targeting both MOPr and DOPr or MOPr-DOPr heteromers especially focusing on their pharmacological effects in vivo. CONCLUSION I found that most of those ligands possesses potent antinociceptive activity (as much as or higher than that of morphine) with reduced side effects such as tolerance. In addition, some of them are also able to reduce or prevent physiological withdrawal symptoms observed under chronic opioid use. Importantly, there are increasing number of evidences that show changes in heteromer expression in various pathological animal models and these strongly argue for targeting heteromers for the development the next generation of pain medication in the near future. Copyright© Bentham Science Publishers; For any queries, please email at [email protected].
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