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Web-Based Advice By way of Aided Reproductive Engineering (myFertiCare): Patient-Centered App Development along with Qualitative Assessment.
This article describes the development of a method to evaluate the acceptance of different snack food textures by children with food texture sensitivities, including children with and without Down syndrome (DS). An in-home use test (HUT) was developed to reflect recent taste study and allow greater recruitment. In this study, parents with children (ages 11-60 months) with DS (CWDS) and without (typically developing, CTD) were recruited and based on responses to several questions, children were categorized as food texture sensitive (TS) or nontexture sensitive (NTS). In total, 111 CWDS (49 TS and 62 NTS) and 107 CTD (42 TS and 65 NTS) participated. To select the food products for assessment, a trained panel profiled commercially available infant and toddler solid snack foods (n = 41), from which 16 products were selected and sorted into four flavor groupings. For the HUT, participating children evaluated each food product once per day for 6 days. Parents recorded their children's reactions to each food product; a panel of trained coders coded each video for verbal and nonverbal behaviors using a novel coding scheme. Parent prompts were also coded. Several challenges were experienced during this study, including poor-quality videos, and standardization of the home environment during the feeding sessions. However, the high degree of successful completion of the HUT (96%) was attributed to the high motivation of the parents involved, as well as the close interaction between the experimenters and the participants on an individual family level.The stability and bonding of a series of hetero-diatomic molecules with general formula (cAAC)EM(CO)n , where cAAC = cyclic alkyl(amino) carbene; E = group 14 elements (C, Si, and Ge); M = transition metal (Ni, Fe, and Cr) have been studied by quantum chemical calculations using density functional theory (DFT) and energy decomposition analysis-natural orbital chemical valence (EDA-NOCV). see more The equilibrium geometries were calculated at the BP86/def2-TZVPP level of theory. The tri-coordinated group 14 complex (1a, 4a, and 7a) in which one of the CO groups is migrated to the central group 14 element from adjacent metal is theoretically found to be more stable when the central atom (E) is carbon. On the other hand, the two-coordinate group 14 element containing metal-complexes (2, 5, 8, 3, 6, and 9) are found to be more stable with their corresponding heavier analogues. The electronic structures of all the molecules have been analyzed by molecular orbital, topological analysis of electron density and natural bond carbonyl.Methods for the treatment of item non-response in attitudinal scales and in large-scale assessments under the pairwise likelihood (PL) estimation framework and under a missing at random (MAR) mechanism are proposed. Under a full information likelihood estimation framework and MAR, ignorability of the missing data mechanism does not lead to biased estimates. However, this is not the case for pseudo-likelihood approaches such as the PL. We develop and study the performance of three strategies for incorporating missing values into confirmatory factor analysis under the PL framework, the complete-pairs (CP), the available-cases (AC) and the doubly robust (DR) approaches. The CP and AC require only a model for the observed data and standard errors are easy to compute. Doubly-robust versions of the PL estimation require a predictive model for the missing responses given the observed ones and are computationally more demanding than the AC and CP. A simulation study is used to compare the proposed methods. The proposed methods are employed to analyze the UK data on numeracy and literacy collected as part of the OECD Survey of Adult Skills.
There is growing evidence on the impact of thin gingival phenotype (TnP) and inadequate keratinized mucosa width (KMW<2mm) around dental implants on peri-implant health. This study investigated the role of TnP and inadequate KMW(<2mm) as risk indicators for peri-implantitis and mucositis and on dental patient-reported outcomes.

Sixty-three patients with 193 implants (mean follow-up of 6.9 ± 3.7 years) were given a clinical and radiographic examination and a questionnaire to assess patient awareness of food impaction and pain/discomfort. Chi-squared tests and regression analysis for clustered data were used to compare outcomes.

Implants with TnP had a statistically higher prevalence of peri-implantitis (27.1%versus 11.3%; PR, 3.32; 95% confidence interval (CI), 1.64-6.72; P=0.001) peri-implant mucositis (42.7%versus 33%; PR, 1.8; 95% CI, 1.12-2.9; P=0.016) and pain/discomfort during oral hygiene (25%versus 5%; PR, 3.7; 95% CI, 1.06-12.96; P=0.044) than thick phenotype. Implants with inadequate KMW had a statistically higher prevalence of peri-implantitis (24.1%versus 17%; PR, 1.87; 95% CI, 1.07-3.25; P=0.027) and peri-implant mucositis (46.6%versus 34.1%; PR, 1.53; 95% CI, 1-2.33; P=0.05) and pain/discomfort during oral hygiene (28%versus 10%; PR, 2.37; 95% CI, 1.1-5.1; P=0.027) than the adequate KMW. TnP was strongly associated with inadequate KMW (PR=3.18; 95% CI, 1.69-6.04; P<0.001).

TnP and inadequate KMW(<2mm) may be significant risk indicators for peri-implant disease and pain/discomfort during brushing.
TnP and inadequate KMW ( less then 2 mm) may be significant risk indicators for peri-implant disease and pain/discomfort during brushing.
The aim of this study was to report the course and outcome of SARS-CoV-2 infection in multiple sclerosis (MS) patients treated with disease-modifying therapies (DMTs) in Poland. A major concern for neurologists worldwide is the course and outcome of SARS-CoV-2 infection in patients with MS treated with different DMTs. Although initial studies do not suggest an unfavourable course of infection in this group of patients, the data is limited.

This study included 396 MS patients treated with DMTs and confirmed SARS-CoV-2 infection from 28 Polish MS centres. Information concerning patient demographics, comorbidities, clinical course of MS, current DMT use, as well as symptoms of SARS-CoV-2 infection, need for pharmacotherapy, oxygen therapy, and/or hospitalisation, and short-term outcomes was collected up to 30 January 2021. Additional data about COVID-19 cases in the general population in Poland was obtained from official reports of the Polish Ministry of Health.

There were 114 males (28.8%) and 282 females (71.
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