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Cardiovascular diseases and cancer, the leading causes of morbidity and mortality in the elderly, share some common mechanisms, in particular inflammation, contributing to their progression and pathogenesis. However, somatic mutagenesis, a driving force in cancer development, has not been generally considered as an important factor in cardiovascular disease pathology. Recent studies demonstrated that during normal aging, somatic mutagenesis occurs in blood cells, often resulting in expansion of mutant clones that dominate hematopoiesis at advanced age. This clonal hematopoiesis is primarily associated with mutations in certain leukemia-related driver genes and, being by itself relatively benign, not only increases the risks of subsequent malignant hematopoietic transformation, but, unexpectedly, has a significant impact on progression of atherosclerosis and cardiovascular diseases. In this review, we discuss the phenomenon of clonal hematopoiesis, the most important genes involved in it, its impact on cardiovascular diseases, and relevant aspects of hematopoietic stem cell biology.During the COVID-19 pandemic, there has been intense interest in political leaders' nonverbal communicative structures (NCS) during televised appearances. This study analyzes the effect of gender on leaders' NCS and presents theoretical and analytical frameworks of gendered NCS. We analyzed 20 televised appearances by 10 heads of state (five males and five females) from democratic Western countries during the COVID-19 pandemic. The findings revealed that gender had a significant effect on leaders' NCS, indicating that leaders presented NCS that corresponded to their gender. Male leaders' masculine NCS included competition, warning, threatening, and scaring behavior, broad proxemics, tension leakage, and illustrative gestures, while female leaders presented feminine NCS of cooperativeness, emotional communication, empathy, optimism, eye contact, and flexible expressions. Furthermore, the effect of gender on leaders' NCS had an interaction effect with the situation of the pandemic, indicating that countries with a female leader had fewer diseased and severe cases and more calmness and healing NCS. The conclusions present theoretical and analytical frameworks that explain the central effect of gender on contemporary leaders' NCS. This study develops advanced distinctive profiles for male versus female leaders' NCS of emotions, cognition, and behavior during a crisis.This paper presents double shear tests performed to investigate factors influencing the bond behavior between basalt fiber-reinforced polymer (BFRP), glass fiber-reinforced polymer (GFRP) laminate, and concrete blocks. In detail, thirty-six twin concrete blocks strengthened with the aforementioned FRP types were tested to evaluate the influence of FRP length, width, and thickness, and their bonding behavior. The 2D-DIC (digital image correlation) technique and several strain gauges bonded along the laminate were used to measure the strain distributions of the FRP-to-concrete interface. The failure mode, ultimate load, load-slip, strain distribution, and bond-slip relationships between the laminates and concrete were analyzed. Furthermore, bond-slip curves were compared with some other existing literature models. The results from the experiment showed that the ultimate load, peak bond stress, and slip increased with the increase in the BFRP and GFRP laminates length, width, and thickness. The values of peak shear stress and the corresponding maximum shear slip were significantly different because of the above-mentioned factors' influence on them. The bond interface that contributes to the bearing of the shear load may grow to an extent and later shift from the loaded end when debonding progresses. Finally, the fractured surfaces of the failed FRP laminates were examined using scanning electron microscope (SEM), revealing that FRP rupture, debonding in concrete, and debonding in an adhesive-concrete interface were the main failure types.Freezing grapes is a winemaking technique known as cryoextraction that intends to modify the composition of the final wines. The changes that take place in the frozen grapes facilitate the transfer of certain compounds from the grape skins into the musts because of the grape's unstructured tissues. For this study, the white grape variety Muscat of Alexandria was selected. learn more Two different cryoextraction procedures have been analyzed as follows (i) Ultrafast freezing, and (ii) liquid nitrogen freezing. The wines obtained using liquid nitrogen freezing exhibited higher levels of terpenoids, as well as higher levels of hydroxylic compounds and fatty acids than both the wines obtained through traditional methods and ultrafast freezing wines. In any case, both freezing techniques produced wines of a more intense aroma compared with those wines obtained by traditional methods. In fact, liquid nitrogen freezing produced the wines with the most intense aroma and were the best valued by the tasting panel.Construction workers fail to recognize a large number of safety hazards. These unrecognized safety hazards can lead to unintended hazard exposure and tragic safety incidents. Unfortunately, traditional hazard recognition interventions (e.g., job hazard analyses and safety training) have been unable to tackle the industry-wide problem of poor hazard recognition levels. In fact, emerging evidence has demonstrated that traditional hazard recognition interventions have been designed without a proper understanding of the challenges workers experience during hazard recognition efforts. Interventions and industry-wide efforts designed based on a more thorough understanding of these challenges can yield substantial benefits-including superior hazard recognition levels and lower injury rates. Towards achieving this goal, the current investigation focused on identifying hazard categories that workers are more proficient in recognizing and others that they are less proficient in recognizing (i.e., hazard recognition patterns). For the purpose of the current study, hazards were classified on the basis of the energy source per Haddon's energy release theory (e.g., gravity, motion, electrical, chemical, etc.). As part of the study, 287 workers representing 57 construction workplaces in the United States were engaged in a hazard recognition activity. Apart from confirming previous research findings that workers fail to recognize a disproportionate number of safety hazards, the results demonstrate that the workers are more proficient in recognizing certain hazard types. More specifically, the workers on average recognized roughly 47% of the safety hazards in the gravity, electrical, motion, and temperature hazard categories while only recognizing less than 10% of the hazards in the pressure, chemical, and radiation hazard categories. These findings can inform the development of more robust interventions and industry-wide initiatives to tackle the issue of poor hazard recognition levels in the construction industry.
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