Notes

Considerations for Social Requires Screening within a Neighborhood Public Health Company.
Emotionally maltreated and neglected participants were less likely to report high level of self-esteem and more likely to report symptoms of depression.

Child maltreatment in the UAE is of a similar magnitude to what reported in other countries around the world and significantly associated with low self-esteem and depressive symptoms.
Child maltreatment in the UAE is of a similar magnitude to what reported in other countries around the world and significantly associated with low self-esteem and depressive symptoms.
Protracted labor is associated with an elevated risk of maternal and fetal complications. Results of randomized controlled trials on the efficacy in labor of phloroglucinol (PHL), a pure antispasmodic drug, are uncertain.

To evaluate whether PHL is effective in shortening the first stage of labor.

MEDLINE, EMBASE, LILACS, Scopus, ClinicalTrials.gov, and the Cochrane Library were searched from inception to July 2020.

Randomized controlled trials (RCTs) concerning women with a singleton vertex pregnancy at term who were treated with PHL.

Relevant data were extracted and tabulated. Review Manager 5.3 was used for data analysis. Primary outcome evaluated was the mean reduction of the first stage of labor.

Five RCTs, including 487 pregnant women, were analyzed. The first stage of labor duration was significantly shorter in the treatment arm compared to the control group [MD-113.21 min (95% CI-119.63,-106.79)]. A significant shortening of the second stage was achieved in the PHL group [MD-11.12 min (95% CI-12.64,-9.75)] while no differences were reported for the third stage.

PHL might represent an effective treatment to shorten the duration of the first and second stage of labor.

A meta-analysis of 5 trials found that Phloroglucinol favorably impacts on the total duration of the labor in primiparae and multiparae women with a singleton pregnancy.
A meta-analysis of 5 trials found that Phloroglucinol favorably impacts on the total duration of the labor in primiparae and multiparae women with a singleton pregnancy.Introduction Statins are powerful lipid-lowering agents which reduce cardiovascular (CV)-related morbidity and mortality. However, a large proportion of patients cannot attain the target low-density lipoprotein cholesterol (LDL-C) levels, despite receiving maximally tolerated doses of high-intensity statins. Also, adherence to treatment may be reduced due to statin-induced myopathy or other side effects. For these reasons, guidelines recommend adding the cholesterol absorption inhibitor ezetimibe.Areas covered Authors discuss the main pharmacological characteristics of rosuvastatin and ezetimibe, their lipid-lowering and pleiotropic effects, as well as the clinical effects of the fixed dose combination of these drugs when used to treat dyslipidemia.Expert opinion The rosuvastatin/ezetimibe combination is safe and effective in patients with hypercholesterolemia or dyslipidemia with or without diabetes and with or without cardiovascular disease. This drug combination enabled higher proportions of patients to achieve recommended LDL-C goals than rosuvastatin monotherapy or the simvastatin/ezetimibe combination, without additional adverse events. Despite the lack of additional CV outcomes data and comparisons with atorvastatin/ezetimibe, rosuvastatin/ezetimibe appears as a potent and generally well-tolerated drug combination eligible for the management of hypercholesterolemia and dyslipidemia in adults. Recently, the 40 mg rosuvastatin/10 mg ezetimibe fixed combination was approved and is also evaluated.There is still a lack of mature researches on the stability mechanism, influencing factors and control technology of the gob-side filling wall, and systematic researches on the cracking forms and characteristics of the stope roof and the stability of the filling wall are rather insufficient. This paper is aimed at investigating the deformation law of the filling wall under the large-span composite hinge fracture of the hard critical block and solving the difficulty that the large-span critical block lateral fracture poses to gob-side entry retaining. Research methods such as theoretical calculation, mechanical analysis, numerical simulation and field test were adopted comprehensively in this study. When the large-span critical block B is divided into two or three parts, its force on the immediate roof decreases with the increase in the number of segments. Meanwhile, as the number of segments grows, the displacement and axial stress of the filling wall both decrease gradually; the tensile failure weakens relatively, while the shear failure changes slightly. Moreover, both the number of shear cracks and the number of tensile cracks in the filling wall are positively correlated with the strain. When the critical block divided into four parts, the amount of lateral displacement is about 190 mm, and the axial displacement reaches the minimum (about 235 mm). The stability of the filling wall along the gob-side entry is closely related to the lateral fracture span of the stope roof. Under the lateral fracture of the hard critical block, a smaller span of the lateral fracture of the critical block corresponds to a smaller force on the filling wall and a weaker damage to the filling wall. The field test result verifies that cleaving the large-span critical block into smaller segments is conducive to reducing surrounding rock and filling wall deformation.Malaria in pregnancy is associated with adverse maternal and perinatal outcomes. The first-line treatment for severe malaria in the second and third trimesters of pregnancy is parenteral artesunate, according to WHO recommendations. Resistance of Plasmodium falciparum to artesunate has not yet been noted in our country. We report a case highly suspicious of such. A pregnant woman presented with the clinical signs of malaria. Delanzomib inhibitor After paraclinical confirmation of the diagnosis, she was admitted and injectable artesunate was given for 72 h at the recommended dosage, with antipyretic without any improvement. Artesunate was therefore replaced by parenteral quinine, with favourable evolution. Resistance of Plasmodium falciparum to artesunate might be present in our country. This patient provides a warning about possible artesunate resistance, and this calls for careful monitoring of other cases of malaria been treated with this drug to ascertain the possibility of resistant cases.
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