Notes

The first-in-class Polymerase Theta Inhibitor selectively goals Homologous-Recombination-Deficient Growths.
This Letter presents, to the best of our knowledge, a novel optical configuration for direct time-resolved measurements of luminescence from singlet oxygen, both in solutions and from cultured cells on photodynamic therapy. The system is based on the superconducting single-photon detector, coupled to the confocal scanner that is modified for the near-infrared measurements. The recording of a phosphorescence signal from singlet oxygen at 1270 nm has been done using time-correlated single-photon counting. The performance of the system is verified by measuring phosphorescence from singlet oxygen generated by the photosensitizers commonly used in photodynamic therapy methylene blue and chlorin e6. The described system can be easily upgraded to the configuration when both phosphorescence from singlet oxygen and fluorescence from the cells can be detected in the imaging mode. Thus, co-localization of the signal from singlet oxygen with the areas inside the cells can be done.Traditional filters are faced with the problems of high price and complex preparation process. It is necessary to find a new method or material to make up for these shortcomings. In this Letter, CsPbBr3 nanocrystals with controllable size were prepared in a tellurite glass matrix by a simple and effective heat treatment process. The absorption wavelength of CsPbBr3 quantum dots gradually shifted to red due to the quantum confinement effect. In addition, the intrinsic photoluminescence intensity of CsPbBr3 quantum dots was reduced by Ce4+-doped quantum dot CsPbBr3 glass, which could shield a short wavelength of 200-530 nm. The uniformly distributed quantum dots ensure high transmittance (>80%) of a long wavelength (560-800 nm), demonstrating that the quantum dot glass material has a broad application prospect as a shortwave shielding material.An optical fiber sensor based on a fiber surface waveguide and Bragg grating is proposed for a simultaneous refractive index (RI) and temperature sensing. The device consists of two fiber Bragg gratings fabricated by a femtosecond laser, one of which is situated in the fiber core for temperature sensing; the other is located in the fiber surface waveguide for both temperature and RI measurements. Isoproterenol sulfate supplier The RI and temperature sensitivities achieved are 10.3 nm/RIU and 9.94 pm/°C, respectively. The device is featured with a compact structure, high robustness, and convenient operation.Some years after the appearance of the so-called non-diffracting beams, there was the development of methods capable of structuring them spatially, with the so-called frozen wave method being the first and, perhaps, the most efficient one. That method allows for modelling the longitudinal intensity pattern of non-diffracting beams, but it is little efficient in controlling their transverse spatial pattern, granting only the possibility of choosing their transverse dimensions, which remain invariant throughout the propagation. In this work, we have extended the frozen wave method in such a way, to control the transverse beam structure along the propagation, in addition to the longitudinal pattern. The new transversally and longitudinally structured beams can have potential applications in areas such as photonics, optical manipulation, optical atom guidance, and lithography.We report an enhanced supercontinuum generation (SCG) from a rare-earth (Pr3+) doped low bandgap zinc borate glass when excited with 60 fs pulses from a Ti-sapphire laser. The emission associated with the absorption bands due to Pr3+ doping (around 420-500 and 580-600 nm) is observed to assist the enhanced SCG.We demonstrate a high-speed optical technique to fabricate plasmonic metasurfaces in a polymer film. The technique is based on a programmable spatial light modulator, which is used to spatially control the photoreduction sites of gold ions in a polyvinyl alcohol film doped with a gold precursor. After irradiation, annealing was used to induce the growth of nanoparticles, producing plasmonic microstructures. Using a 473 nm excitation wavelength, microscopic plasmonic gratings, and meta-atom arrays with arbitrary orientations, an effective nanostructure size of ∼700nm and constituent nanoparticles with average size of ∼37nm were created. The technique enables a cost-effective and straightforward light-based approach to fabricate plasmonic metasurfaces with tunable properties.Metalenses possess the extraordinary capability to tailor the wavefront of light with compact metastructures. However, it remains challenging to eliminate chromatic aberration and realize multifunctionality. Here we report an achromatic bifocal metalens (ABM) made of three-dimensional standing nano blocks (SNBs). By introducing a height gradient to SNBs, the ABM can achieve achromatic focusing in the wavelength range of 760-1550 nm with two different focal lengths by merely orthogonally switching the linear polarization of the incident beam. Such an achromatic multi-functional element may have applications in polarization sensing/display and shared-aperture optics design, among many others.Bacterial cellulose (BC) spheres have been increasingly researched since the popularization of BC as a novel material. This protocol presents an affordable and simple method for BC sphere production. In addition to producing these spheres, an encapsulation method for solid particles has also been identified. To produce BC spheres, water, black tea, sugar, vinegar, and bacterial culture are combined in a baffled flask and the contents are agitated. After determining the proper culture conditions for BC sphere formation, their ability to encapsulate solid particles was tested using biochar, polymer beads, and mine waste. Spheres were characterized using ImageJ software and thermal gravimetric analysis (TGA). Results indicate that spheres with 7.5 mm diameters can be made in 7 days. Adding various particles increases the average size range of the BC capsules. The spheres encapsulated 10 - 20% of their dry mass. This method shows low-cost sphere production and encapsulation that is possible with easily obtainable materials. BC spheres may be used in the future as a contaminant removal aid, controlled release fertilizer coating, or soil amendment.
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