Notes

Current Advancements inside ROS-Sensitive Nano-Formulations regarding Atherosclerosis Applications.
eserve parathyroid glandular tissue with a lower incidence of post-operative hypocalcemia.
In our cohort of patients who underwent total (pharyngo)laryngectomy with hemi- or total thyroidectomy, the use of near-infrared autofluorescence improved medium term postoperative hypocalcemia rates. This new technology helps to achieve a better calcemic outcome compared to the standard naked eye approach, since it helps the surgeon to identify and preserve parathyroid glandular tissue with a lower incidence of post-operative hypocalcemia.
Familial Mediterranean fever (FMF) is a disease of the innate immune system. The disease is prevalent in the Mediterranean region. A comprehensive bibliometric analysis of the published literature on FMF indexed in the SCI-Expanded is lacking.

To review the global research trend, developments, leading authors, journals, institutions, and countries, and visualization mapping of the published scientific literature on FMF.

The data were obtained from SCI-Expanded of the WoSCC database. The obtained data were analyzed using Bibliometrix An R-tool and an online Bibliometric tool. P-value less than 0.05 was considered statistically significant.

In this study, a total of 1665 publications (research article, 92% and review, 8%) on FMF were analyzed and characterized. These publications were authored by 5630 authors, and published in 465 journals. The scientific production in FMF research has been increasing over time (p < 0.0001), with scientific annual growth of 3.96%. The most frequent year of publicatiod recent trend topics in FMF research were validity, reliability, endothelial dysfunction, management, and recommendations. Moreover, regional collaboration between less active countries should be extended in order to expand FMF-related research and thus prevent and control the disease in the near future.
Achieving normal rotational alignment of both components in total knee arthroplasty (TKA) is essential for improved knee survivorship and function. However, malrotation is a known complication resulting in higher revision rates. Understanding malrotation of the components and its concomitant clinical and functional outcomes are important for early diagnosis and management. The purpose of this study was to evaluate the effect of malrotation on clinical outcomes and failure modes in both single and combined rotational malalignment.

From our hospital database of 364 revisions, a cohort of 76 knees with patellar maltracking, stiffness, reduced range of motion and early aseptic failure were reviewed and investigated for component malrotation using computed tomography following Berger protocol. CT findings confirmed component malrotation in 70 of these patients. Investigations included (1) measurement of femoral component malrotation using surgical transepicondylar axis, (2) measurement of tibial component malrotation using anteroposterior axis and (3) measurement of combined component rotational errors.

The correlation of CT analysis and clinical outcomes after primary TKA revealed association of patellar maltracking with femoral internal rotation, pain and instability with tibial internal rotation and knee stiffness in patients with combined component malrotation as the commonest mode of presentation. Our study showed that patients with isolated femoral, tibial and combined malrotation presented at a mean period of 3.4 ± 1.34, 1.7 ± 0.8 and 2.3 ± 0.69years, respectively, after the index surgery. Post-revision, the mean Knee Society Score and Oxford Knee Score improved from 29.1 to 78.7, and 10.5 to 32.8, respectively, and the mean range of motion improved from 74.9 ± 24.8 to 97.1 ± 12.7 degrees at a mean follow-up of 42months.

Early detection of malrotation in TKA and its management with revision of both components can lead to better clinical and functional outcomes.

III.
III.
The purpose of this study was to compare the image quality of the 3D T2-weighted images accelerated using conventional method (CAI-SPACE) with the images accelerated using compressed sensing (CS-SPACE) in pediatric brain imaging.

A total of 116 brain MRI (53 with CAI-SPACE and 63 with CS-SPACE) were obtained from children 16years old or younger. Quantitative image quality was evaluated using the apparent signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). The sequences were qualitatively evaluated for overall image quality, general artifact, cerebrospinal fluid (CSF)-related artifact, and grey-white matter differentiation. The two sequences were compared for the total and two age groups (< 24months vs. ≥ 24months).

Compressed sensing application in 3D T2-weighted imaging resulted in 8.5% reduction in scanning time. Gefitinib-based PROTAC 3 Quantitative image quality analysis showed higher apparent SNR (median [Interquartile range]; 29 [25] vs. 23 [14], P = 0.005) and CNR (0.231 [0.121] vs. 0.165 [0.120], P = 0.027) with CS-SPACE compared to CAI-SPACE. Qualitative image quality analysis showed better image quality with CS-SPACE for general (P = 0.024) and CSF-related artifact (P < 0.001). CSF-related artifacts reduction was prominent in the older age group (≥ 24months). Overall image quality (P = 0.162) and grey-white matter differentiation (P = 0.397) were comparable between CAI-SPACE and CS-SPACE.

Compressed sensing application in 3D T2-weighted images modestly reduced acquisition time and lowered CSF-related artifact compared to conventional images of the pediatric brain.
Compressed sensing application in 3D T2-weighted images modestly reduced acquisition time and lowered CSF-related artifact compared to conventional images of the pediatric brain.
The utility of incidental appendectomy, appendectomy during another index surgery in the absence of appendicitis, has not been evaluated in the pediatric population during cholecystectomy. This study sought to compare nationwide outcomes after cholecystectomy with incidental appendectomy in children.

Patients ≤ 18years old who underwent cholecystectomy from 2010-2014 were identified from the Nationwide Readmissions Database. A propensity score-matched analysis (PSMA) with > 40 covariates including demographics, comorbidities, and hospitalization factors was performed between those receiving cholecystectomy alone versus incidental appendectomy at the time of cholecystectomy.

34,390 patients underwent cholecystectomy (median age 15 [13-17] years). Laparoscopic (92%) approach was utilized most frequently, with 2% requiring conversion to open cholecystectomy. PSMA demonstrated a higher frequency of perforation or laceration of adjacent organs occurring in those receiving cholecystectomy alone during index admission. No significant differences in readmissions within 30days or the calendar year were detected. Those undergoing cholecystectomy alone had higher overall readmission costs ($11,783 [$4942-$39,836] vs. $6,100 [$2358-$19,719] cholecystectomy with appendectomy; p = 0.010).

This nationwide PSMA indicates that incidental appendectomy in pediatric cholecystectomies is not associated with higher postoperative complications, cost, or readmissions. This suggests that incidental appendectomy during cholecystectomy is safe, cost-effective, and worthy of future study.

Level III.
Level III.Antifogging coatings for infrastructures and transparent objects have attracted much attention lately from the perspective of safety and visibility. We have developed a one-pot process to fabricate transparent composite films showing long-lasting antifogging and fast repeatable self-healing properties based on an integral blend (IB) method. This method does not require any specific pretreatments of inorganic fillers/particles. Thus, the precursor solutions could be prepared in a single step by simply mixing raw materials, e.g., poly(vinylpyrrolidone) (PVP) having different molecular weights (MWs 55, 360, and 1300 k), nano-clay particles (NCPs), and amino-terminated organosilane (AOS). In this study, to control the degree of cross-linking between the PVP matrices and NCPs, addition of AOS as a cross-linker to the PVP matrices (weight percentage of AOS to the PVP matrices, α = 0.01-300%) was carefully controlled. Transparency and self-healing abilities/kinetics of the resulting samples were found to be strongly influenced by both the MWs of PVP and α values. Samples spin-coated with the lowest MW of PVP (55 k) and α values of 0.01-1% gave highly transparent and durable antifogging performance. For example, no fogging was observed for 7 days under >80% relative humidity, and scratches about 30 μm in width could be completely self-healed within a few hours. However, samples with α > 10% gave opaque/grayish films that did not show any self-healing abilities because of an increase in cross-linking of the matrices. The optimized precursor solution was also deposited directly onto the glass slides covered with a transparent porous silica nano-framework (SNF) by a spray-coating method. Due to the formation of the hard and superhydrophilic/hygroscopic SNF with a large surface area, durability of antifogging and self-healing properties of the composite films were moderately improved, compared to those on the flat glass slides.
Oral submucous fibrosis (OSF) is a common chronic condition with poor prognosis, and existing therapies for OSF are limited in effectiveness. This study was designed to explore the role of miR-497 in arecoline (AR)-induced OSF.

After miR-497 was silenced or overexpressed in buccal mucosa fibroblasts (BMFs), different concentrations of AR (5-200 μg/ml) were applied to incubate BMFs, and 50 μg/ml of AR was chosen for subsequent experiments. Thereafter, collagen gel contraction assay was used to detect the contractile capacity of BMFs. Transwell assay and wound healing assay were applied to detect migration and invasiveness of the cells. In addition, immunofluorescence staining, qRT-PCR and western blot were conducted to measure the expression of miR-497, collagen I and α-SMA, as well as the phosphorylation of Smad2 and Smad3.

After successful inhibition or overexpression of miR-497 in AR-induced BMFs, the results showed that miR- 497 inhibition suppressed the contractility, migration and invasiveness of AR-induced BMFs, whereas overexpression of miR-497 produced the opposite. In addition, miR-497 inhibition down-regulated the expression level of collagen I and α-SMA in AR-exposed BMFs. Furthermore, TGF-β1 expression, Smad2 and Smad3 phosphorylation were also repressed in AR-induced BMFs after miR-497 inhibition. Correspondingly, overexpression of miR-497 reversed the expression of the aforementioned proteins.

miR-497 inhibition may attenuate OSF by inhibiting myofibroblast transdifferentiation in BMFs via the TGF-β1/Smads signaling pathway, indicating that miR-497 might represent an underlying target for treating OSF.
miR-497 inhibition may attenuate OSF by inhibiting myofibroblast transdifferentiation in BMFs via the TGF-β1/Smads signaling pathway, indicating that miR-497 might represent an underlying target for treating OSF.
This study compared the success of dental students with flipped classroom and traditional classroom learning in the restorative dentistry course for the first time at the Faculty of Dentistry of Reims during the 2019- 2020 academic year, influenced by the Covid-19 pandemic, and analysed the correlation with students' feelings. The use of an active learning method can improve success during final exams and increase the motivation of students.

The same teacher taught half of the restorative dentistry course in the flipped classroom approach and the other half as traditional classroom. For the flipped classroom, students were required to complete their homework online before the face-to-face sessions. An exam at the beginning and the end of the semester was conducted with questions about concepts learned with each learning method. Statistical analysis was performed using a t-test at the 0.05 significance level. A questionnaire on satisfaction was conducted to determine the students' opinion on this new learning method in the flipped classroom compared to the traditional classroom.
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