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Thereby, substantial acquisition time reduction with SIPs seems possible without image quality degradation.Herein, we report the synthesis of 2-spirocyclohexylindolines based on a Lewis acid mediated cyclization. This diastereoselective procedure provides the target structures in a straightforward way via dual activation.Targeting the gut-liver axis by manipulating the intestinal microbiome is a promising therapy for nonalcoholic fatty liver disease (NAFLD). This study modulated the intestinal microbiota to explore whether resistant dextrin, as a potential prebiotic, could ameliorate high-fat diet (HFD)-induced hepatic steatosis in C57BL/6J mice. After two months of feeding, significant hepatic steatosis with mitochondrial dysfunction was observed in the HFD-fed mice. However, the concentrations of triglycerides and malondialdehyde in liver tissue and the levels of alanine aminotransferase and aspartate aminotransferase in the serum of mice fed an HFD plus resistant dextrin diet (HFID) were significantly decreased compared to the HFD-fed mice. Additionally, hepatic mitochondrial integrity and reactive oxygen species accumulation were improved in HFID-fed mice, ameliorating hepatic steatosis. The fecal microbiome of HFD-fed mice was enriched in Bifidobacterium, Lactobacillus, and Globicatella, while resistant dextrin increased the abundance of Parabacteroides, Blautia, and Dubosiella. Major changes in fecal metabolites were confirmed for HFID-fed mice, including those related to entero-hepatic circulation (i.e., bile acids), tryptophan metabolism (e.g., indole derivatives), and lipid metabolism (e.g., lipoic acid), as well as increased antioxidants including isorhapontigenin. Furthermore, resistant dextrin decreased inflammatory cytokine levels and intestinal permeability and ameliorated intestinal damage. Together, these findings augmented current knowledge on prebiotic treatment for NAFLD.A transition-metal-free strategy for the synthesis of 2-(cyclobut-1-en-1-yl)-1H-indoles under mild conditions is described herein. L-α-Phosphatidylcholine A series of substituted 2-(cyclobut-1-en-1-yl)-1H-indoles are accessed by a one-pot cyclobutenylation/deprotection cascade from N-Boc protected indoles. Preliminary experimental and density functional theory calculations suggest that a Boc-group transfer is involved in the underlying mechanism.Correction for 'A novel concept of two-component dielectric function for gold nanostars theoretical modelling and experimental verification' by Nikolai G. Khlebtsov et al., Nanoscale, 2020, 12, 19963-19981, DOI 10.1039/D0NR02531C.Hybrid electrocatalysts derived from surface self-reconstruction during reaction processes can facilitate charge transfer between different phases and nanostructures by their unique interfaces. Herein, amorphous/crystalline hybrid iron disulfide obtained by self-reconstruction is developed for the first time for the oxygen evolution reaction (OER). The amorphous/crystalline hybrid FeS2 catalyst exhibited a high OER activity with an overpotential of only 189.5 mV (IR-corrected) to deliver 10 mA cm-2 in 1.0 M KOH, which was superior to that of the commercial RuO2. Notably, in the two-electrode system with the amorphous/crystalline hybrid FeS2 as the anode electrocatalyst and Pt/C as the cathode, the catalytic activity towards the overall water splitting was enhanced with a voltage of only 1.43 V at 10 mA cm-2. The phase, composition and surface structure were changed greatly before and after the reaction. All these surface reconstructions after the OER reaction may play significant roles in the high electronic catalytic efficiency. Therefore, the study of the surface reconstruction of catalysts during the reaction process is very important for the structure-performance relationship and the design of efficient hybrid electrocatalysts.The coupling of piezoelectric properties with Rashba spin-orbit coupling (SOC) has proven to be the limit breaker that paves the way for a self-powered spintronic device (ACS Nano, 2018, 12, 1811-1820). For further advancement in next-generation devices, a new class of buckled, hexagonal magnesium-based chalcogenide monolayers (MgX; X = S, Se, Te) have been predicted which are direct band gap semiconductors satisfying all the stability criteria. The MgTe monolayer shows a strong SOC with a Rashba constant of 0.63 eV Å that is tunable to the extent of ±0.2 eV Å via biaxial strain. Also, owing to its broken inversion symmetry and buckling geometry, MgTe has a very large in-plane as well as out-of-plane piezoelectric coefficient. These results indicate its prospects for serving as a channel semiconducting material in self-powered piezo-spintronic devices. Furthermore, a prototype for a digital logic device can be envisioned using the ac pulsed technology via a perpendicular electric field. Heat transport is significantly suppressed in these monolayers as observed from their intrinsic low lattice thermal conductivity at room temperature MgS (9.32 W m-1 K-1), MgSe (4.93 W m-1 K-1) and MgTe (2.02 W m-1 K-1). Further studies indicate that these monolayers can be used as photocatalytic materials for the simultaneous production of hydrogen and oxygen on account of having suitable band edge alignment and high charge carrier mobility. This work provides significant theoretical insights into both the fundamental and applied properties of these new buckled MgX monolayers, which are highly suitable for futuristic applications at the nanoscale in low-power, self-powered multifunctional electronic and spintronic devices and solar energy harvesting.Twenty-nine triterpenes were obtained from the fruits of Ziziphus jujuba Mill. through various chromatography methods, and their stereo-structures were confirmed by spectroscopic methods. Among them, 2α,3β,20-trihydroxylupane-28-oic acid (1) was identified as a new compound, and the 1H and 13C NMR data of 7, 8 and 23, as well as the 13C NMR data of 17 are reported here for the first time. Meanwhile, the nitric oxide (NO) inhibitory activities of all compounds were examined in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. As results, compounds 2, 7, 10-13, 15, 16, 18-21, 26-29 were found to play important roles in suppressing NO production at 5 μM. The structure-activity relationships (SARs) on NO inhibition indicated that the ursolic and oleanolic acid skeletons, p-coumaroyl group substitution, six-membered A ring, and deoxygenation (loss of C[double bond, length as m-dash]O) in the C ring showed a more positive effect on the NO inhibitory activity of triterpenes, while the reduction of the A ring C[double bond, length as m-dash]O to OH was a negative factor.
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