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The review ends with a critical conclusion on existing assays and suggests constructive improvements on how to develop an adequate and universal antioxidant assay.Objective High-grade serous ovarian cancers (HGSOC) are heterogeneous, often diagnosed at an advanced stage, and associated with poor overall survival (OS, 39% at five years). There are few data about the prognostic factors of late relapses in HGSOC patients who survived ≥five years, long-term survivors (LTS). The aim of our study is to assess the probability of survival according to the already survived time from diagnosis. Methods Data from HGSOC patients treated between 1995 and 2016 were retrospectively collected to estimate the conditional probability of survival (CPS), probability of surviving Y years after diagnosis when the patient had already survived X years, and to determine the LTS prognostic factors. The primary endpoint was OS. Results 404 patients were included; 120 of them were LTS. Patients were aged 61 years (range 20-89), WHO performance status 0-1 in 86.9% and 2 in 13.1%, and Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) staging III and IV in 82.7% and 17.3% patients. Breast cancer (BRCA) status was available in 116 patients (33% mutated), including 58 LTS (36% mutated). No macroscopic residual disease was observed in 58.4% patients. First-line platinum-based chemotherapy plus paclitaxel was administered in 80.4% of patients (median six cycles (range 1-14)). After a 9 point 3-year follow-up, median OS was four years (95% CI 3.6-4.5). The CPS at five years after surviving one year was 42.8% (95% CI 35.3-48.3); it increased to 81.7% (95% CI 75.5-87.8) after four survived years. Progression-free interval>18 months was the only LTS prognostic factor in the multivariable analysis (hazard ratio (HR) = 0.23; 95% CI 0.13-0.40; p less then 0.001). Conclusion The CPS provided relevant and encouraging clinical information on the life expectancy of HGSOC patients who already survived a period of time after diagnosis. LTS prognostic factors are useful for clinicians and patients.Allometric scaling can be used for the extrapolation of pharmacokinetic parameters from adults to children. The objective of this study was to predict clearance of therapeutic proteins (monoclonal and polyclonal antibodies and non-antibody proteins) allometrically in preterm neonates to adolescents. There were 13 monoclonal antibodies, seven polyclonal antibodies, and nine therapeutic proteins (non-antibodies) in the study. The clearance of therapeutic proteins was predicted using the age dependent exponents (ADE) model and then compared with the observed clearance values. There were in total 29 therapeutic proteins in this study with 75 observations. The number of observations with ≤30%, ≤50%, and >50% prediction error was 60 (80%), 72 (96%), and 3 (4%), respectively. Overall, the predicted clearance values of therapeutic proteins in children was good. The allometric method proposed in this manuscript can be used to select first-in-pediatric dose of therapeutic proteins in pediatric clinical trials.This study aims to evaluate the safety and efficacy of a poly lactic-co-glycolic acid (PLGA)-coated β-tricalcium phosphate (β-TCP) with N-methyl-2-pyrrolidone (NMP) liquid activator (PLGA/β-TCP) on alveolar ridge preservation after tooth extraction in dog mandible. Thirty-two extraction sites were prepared in eight dog mandibles. A distal root of the mandibular premolar was extracted and randomly grafted with one of the following bone substitutes (1) PLGA/β-TCP, (2) β-TCP, or (3) left empty as a control, and wounds were closed with keratinized mucosa graft. Post-operative wound healing was observed and scored to evaluate safety. After 12 and 24 weeks, the bone regeneration was evaluated with micro-computed tomography (CT) images and histomorphometric analyses. Gingival epithelization progressed over time without complication or infection. Micro-CT images and histological observation revealed that both PLGA/β-TCP and β-TCP granules supported sufficient new bone formation. Citarinostat Although bone formation and substrate resorption were delayed slightly with the PLGA and the NMP-containing plasticizer as compared to those treated with conventional β-TCP, it can be concluded that the PLGA and the NMP-containing plasticizer that facilitated the in situ hardening properties of the material had no negative influence on the biocompatibility of the material.Global Navigation Satellite System (GNSS) technology is widely used for geodetic monitoring purposes. However, in cases where a higher risk of receiver damage is expected, geodetic GNSS receivers may be considered too expensive to be used. As an alternative, low-cost GNSS receivers that are cheap, light, and prove to be of adequate quality over short baselines, are considered. The main goal of this research is to evaluate the positional precision of a multi-frequency low-cost instrument, namely, ZED-F9P with u-blox ANN-MB-00 antenna, and to investigate its potential for displacement detection. We determined the positional precision within static survey, and the displacement detection within dynamic survey. In both cases, two baselines were set, with the same rover point equipped with a low-cost GNSS instrument. The base point of the first baseline was observed with a geodetic GNSS instrument, whereas the second baseline was observed with a low-cost GNSS instrument. The results from static survey for both baselines showed comparable results for horizontal components; the precision was on a level of 2 mm or better. For the height component, the results show a better performance of low-cost instruments. This may be a consequence of unknown antenna calibration parameters for low-cost GNSS antenna, while statistically significant coordinates of rover points were obtained from both baselines. The difference was again more significant in the height component. For the displacement detection, a device was used that imposes controlled movements with sub-millimeter accuracy. Results, obtained on a basis of 30-min sessions, show that low-cost GNSS instruments can detect displacements from 10 mm upwards with a high level of reliability. On the other hand, low-cost instruments performed slightly worse as far as accuracy is concerned.
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