Notes

A robotically pushed form of Kirigami like a route to 3D mesostructures within micro/nanomembranes.
Three patients have elected to discontinue enzyme therapy.Altered energy metabolism of cancer cells shapes the immune cell response in the tumor microenvironment that facilitates tumor progression. Herein, we reported the novel of tumor cell-expressed Piwi Like RNA-Mediated Gene Silencing 1 (PIWIL1) in mediating the crosstalk of fatty acid metabolism and immune response of human hepatocellular carcinoma (HCC). PIWIL1 expression in HCC was increased compared to normal hepatic tissues and was positively correlated with the proliferation rate of HCC cell lines. PIWIL1 overexpression accelerated in vitro proliferation and in vivo growth of HCC tumors, while PIWIL1 knockdown showed opposite effects. PIWIL1 increased oxygen consumption and energy production via fatty acid metabolism without altering aerobic glycolysis. Inhibition of fatty acid metabolism abolished PIWIL1-induced HCC proliferation and growth. RNA-seq analysis revealed that immune system regulation might be involved, which was echoed by the experimental observation that PIWIL1-overexpressing HCC cells attracted myeloid-derived suppressor cells (MDSCs) into the tumor microenvironment. MDSCs depletion reduced the proliferation and growth of PIWIL1-overexpressing HCC tumors. Complement C3, whose secretion was induced by PIWIL1 in HCC cells, mediates the interaction of HCC cells with MDSCs by activated p38 MAPK signaling in MDSCs, which in turn initiated expression of immunosuppressive cytokine IL10. Neutralizing IL10 secretion reduced the immunosuppressive activity of MDSCs in the microenvironment of PIWIL1-overexpressing HCC. Taken together, our study unraveled the critical role of PIWIL1 in initiating the interaction of cancer cell metabolism and immune cell response in HCC. Cannabinoid Receptor agonist Tumor cells-expressed PIWIL1 may be a potential target for the development of novel HCC treatment.
Topical administration of oral gel may reduce radiotherapy-related oral complications. The aim of this study was to examine clinical and microbiological effects of self-administration of different gel formulations to oral mucosa in head and neck cancer patients.

Twenty-seven subjects were recruited from outpatients who underwent radiotherapy of at least 50 Gy to the head and neck area. They were randomly assigned to oral gel with the following different ingredients placebo, chlorhexidine, curry leaf, propolis, and turmeric. Before and after intervention, oral symptoms were evaluated, and nine oral pathogens in saliva were also quantified using real-time PCR.

Twenty-five subjects completed the study and their data were analyzed. The number of Porphyromonas gingivalis in saliva significantly decreased after treatment with propolis gel, but not after any other treatments. Propolis gel treatment also relieved oral pain in all subjects who had oral pain at the baseline.

Topical administration with propolis gel may not only reduce P. gingivalis carriage in saliva, but also relieve oral pain.

A future larger-scale clinical trial of oral propolis gel is needed to determine its clinical efficacy in radiotherapy-related oral complications of head and neck cancer patients.
A future larger-scale clinical trial of oral propolis gel is needed to determine its clinical efficacy in radiotherapy-related oral complications of head and neck cancer patients.Cigarette smoking contributes to numerous diseases and is one of the leading causes of death in the United States. Smoking behaviors vary widely across race/ethnicity, but it is not clear why. Here, we examine the contribution of genetic ancestry to variation in two smoking-related traits in 43,485 individuals from four race/ethnicity groups (non-Hispanic white, Hispanic/Latino, East Asian, and African American) from a single U.S. healthcare plan. Smoking prevalence was the lowest among East Asians (22.7%) and the highest among non-Hispanic whites (38.5%). We observed significant associations between genetic ancestry and smoking-related traits. Within East Asians, we observed higher smoking prevalence with greater European (versus Asian) ancestry (P = 9.95 × 10-12). Within Hispanic/Latinos, higher cigarettes per day (CPD) was associated with greater European ancestry (P = 3.34 × 10-25). Within non-Hispanic whites, the lowest number of CPD was observed for individuals of southeastern European ancestry (P = 9.06 × 10-5). These associations remained after considering known smoking-associated loci, education, socioeconomic factors, and marital status. Our findings support the role of genetic ancestry and socioeconomic factors in cigarette smoking behaviors in non-Hispanic whites, Hispanic/Latinos, and East Asians.
Sarcopenia is a geriatric syndrome characterised by the progressive loss of skeletal muscle mass, muscular strength, and physical performance; it carries the risk of physical incapacity and reduced quality of life. This work reported the prevalence of sarcopenia in people aged ≥65 years, all in-patients at the Hospital Central de la Defensa Gómez Ulla, as determined by three sets of diagnostic criteria. The suitability of the indistinct use of these criteria sets was discussed.

This was a cross sectional study. Sarcopenia was diagnosed depending on muscle mass, strength and functionality according to the European Working Group on Sarcopenia in Older People (EWGSOP), EWSOP2 and SARCF criteria. This study involved 295 people, all aged ≥65 years, and all of whom had been admitted to the above hospital between 1st March and 30th September 2018. Sampling was consecutive and performed at the internal medicine ward.

The overall prevalence of sarcopenia was 43.7% [95%CI 38-49.4%] according to the EWGSOP criteria, 28.5% [23.3-33.7%] according to EWGSOP2, and 37.6% [32-43.1%] according to SARCF. The EWGSOP criteria showed sarcopenia to be significantly more common among men than women (p<0.05).

The prevalence of sarcopenia recorded differed depending on the set of criteria used; they cannot, therefore, be used indistinctly for the diagnosis of this condition. Rather, given the results obtained, it would seem reasonable, in Europe, to continue using the EGSWOP criteria while research continues in this area.
The prevalence of sarcopenia recorded differed depending on the set of criteria used; they cannot, therefore, be used indistinctly for the diagnosis of this condition. Rather, given the results obtained, it would seem reasonable, in Europe, to continue using the EGSWOP criteria while research continues in this area.
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