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Topological Analysis of Regulating Networks Unveils Functionally Essential Family genes and miRNAs Mixed up in Difference regarding Mesenchymal Come Cells.
Missed, migrated disc fragments can be implicated as a cause of low back pain, radiculopathy or cauda equina syndrome, especially in the absence of visible disc herniation. A high index of suspicion needs to be maintained in those cases with unexplained and persistent symptoms and/or no obvious disc herniation on MR images.We aimed to investigate the effect of aquatic exercise on immune response in pre-frailty elderly women. Forty pre-frailty elderly women were recruited from the Community Center. The 12-week supervised aquatic exercise program intervention consisted of 3 days per week. IgA, IgG, and IgM were significantly increased, and IgE was significantly decreased in the exercise group. Tension-anxiety, depression, and confusion were significantly decreased, and anger-hostility was significantly increased in the exercise group. This study indicates that an aquatic exercise is an effective lifestyle intervention strategy for improving immune function and mood state in pre-frailty elderly women.Purpose Sampling lesbian, gay, and bisexual (LGB) people to recruit a national probability sample is challenging for many reasons, including the low base rate of LGB people in the population. To address this challenge, researchers have relied on diverse approaches to sampling LGB people. We aimed to test an innovative method to assemble a U.S. national probability sample of non-transgender sexual minority adults. Methods Our approach used two phases. In Phase 1, we identified LGBT respondents in a probability general population sample. These respondents were then queried about their sexual orientation and gender identity using short screening questions to identify non-transgender sexual minority respondents. In Phase 2, the identified sexual minority respondents completed the targeted survey online or on a mailed questionnaire. Results In Phase 1, using random-digit dialing, a nationally representative sample of 366,644 respondents were screened in a brief telephone interview. Of them, 3.5% (n = 12,837) identified as LGB or transgender. In Phase 2, eligible respondents were asked to participate in a self-administered survey questionnaire. Eligibility was based on gender identity, age, race and ethnicity, and educational restrictions. Of the 3525 who were eligible, 81% (n = 2840) agreed to participate in the study (78% agreed to use the web version and 22% the mailed questionnaire), and 49% of web surveys and 46% of mailed surveys were completed. The final sample included 1331 respondents. Conclusion The benefits of this approach include the ability to assess sexual minority-specific content in a national probability sample; challenges include high cost and low base rates for Asian and American Indian or Alaska Native individuals in the United States.Purpose Sexual minority women (SMW) may have a different distribution of breast cancer risk factors than their heterosexual peers. Epidemiologic studies of breast cancer in SMW have been limited, and many use only proxy variables to identify SMW in data sets, introducing selection bias. We utilized National Health Interview Survey (NHIS) data to compare breast cancer risk factors, screening, and prevalence between SMW and non-SMW. Methods We identified female respondents to the NHIS from 2013 to 2017, selected women ≥40 years old and stratified by sexual orientation. We compared demographics and health maintenance variables and prevalence of breast cancer diagnosis between groups and performed a multivariable analysis of breast cancer risk. Results Of 58,378 women ≥40 years old, 1162 (2.0%) were identified as SMW. SMW were younger and more likely to use tobacco and alcohol, be younger at menarche, and be nulliparous. SMW also reported less preventive care, and despite reporting equivalent rates of mammography, were more likely to obtain mammograms due to an identifiable problem and not simply for screening purposes. Prevalence of breast cancer was similar between SMW and non-SMW (4.7% vs. 5.0%, p = 0.67), and SMW status was not associated with breast cancer diagnosis on univariate and multivariable logistic regression (p = 0.14 and p = 0.07, respectively). Conclusion Despite finding no difference in breast cancer prevalence between SMW and non-SMW, there was evidence for differences in the utilization of breast care. Further studies of breast cancer incidence, characteristics (including subtype and stage), treatment, and survival for SMW are needed.Sexual minority adolescents from religious contexts may be at high risk of mental health issues due to religious identity dissonance. This study investigated the cognitive strategies used to manage antihomosexual religious messages and resolve religious identity dissonance among sexual minority adolescents. In 2014, 46 adolescents were interviewed in Los Angeles, CA. Youths were prompted to discuss experiences with religion, antihomosexual messages, and their strategies for managing these messages. Ninety-one percent of the sample reported hearing antihomosexual religious messages. PMSF purchase Messages came from multiple sources (e.g., parents, pastors) and contained three types of content (i.e., creation, sin, and afterlife). A quarter of the sample reported religious identity dissonance. Three primary strategies to manage antihomosexual messages emerged. Findings indicate that all youths, including nonreligious youths, use cognitive strategies to manage negative messages and that these strategies relate to current religious identification.Non-pathological aging is associated with significant cognitive deficits. Thus, the underlying neurobiology of aging-associated cognitive decline warrants investigation. In a recent study, Chong et al. (2019) provided insights into the association between cognitive decline and the loss of functional specialization in the brains of older adults. Here, we introduce the novel graph theoretical approach utilized, and discuss the significance of their findings and broader implications on aging. We also provide alternate perspectives of their findings, and suggest directions for future work.The mediating effect of perceived social support on the influence of insecure attachment orientations on internalized homophobia was assessed in a group of 70 Italian gay men (mean age = 28.8, SD = 6.2, range 19-46 years). Participants completed self-report measures of adult attachment (Experiences in Close Relationships-Revised), perceived social support (Multidimensional Scale of Perceived Social Support), and internalized homophobia (Measure of Internalized Sexual Stigma for Lesbians and Gay). Higher levels of attachment anxiety and avoidance, and perceptions of lower social support were correlated with higher levels of internalized homophobia. The mediation analyses showed that only attachment anxiety, but not avoidance, may have a direct link with internalized homophobia, while both anxiety and avoidance may have an indirect influence on internalized homophobia mediated by perceived social support. Improving social support can reduce the negative effects of homophobia on gay men, thus mitigating the detrimental fallout of any insecure attachment orientations.
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