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ension should be added.Few African studies have focused on resilience factors related to engagement in HIV-related care among people living with HIV; instead, many studies have identified health risk factors and barriers within this population. Informed by the Disability-Stress-Coping Model of Adjustment, a qualitative study was conducted to develop a better understanding of psychosocial factors that can promote positive behaviours and subjective wellness for people living with HIV in Accra, Ghana. Thirty patients from the two largest HIV clinics in Accra participated in in-depth individual interviews. Using a thematic analysis approach, three individual-level factors related to resilience and subjective wellness were identified (1) holding positive attitudes towards the pathway from HIV testing and diagnosis to healthy living with HIV; (2) placing appropriate (but not absolute) levels of trust in the clinical care environment; and (3) judicious disclosure of their HIV status to key individuals. Findings support a resilience framework that focuses on individual strengths and positive adaptations to HIV diagnosis in order to enhance understanding and promote the HIV care continuum for people living with HIV in this context. Development of resilience-focused approaches to public health intervention is particularly important in low-resource settings such as Ghana where research tends to focus on deficiencies and healthcare inadequacies for people living with HIV.Background Despite the availability of prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) services, many factors and reasons prevent mothers from accessing these services. HIV prevalence is still high among South African women of reproductive age and mother-to-child-transmission (MTCT) is a concern. This study ascertained the perspectives of healthcare workers regarding availability and accessibility of the PMTCT programme.Objective To explore and describe the perspectives of healthcare workers regarding availability and accessibility of the PMTCT programme.Method Qualitative research with exploratory-descriptive design was utilised. Data were collected from 21 healthcare workers using three focus-group discussions. The participants were selected based on rendering the PMTCT programme services for more than two years. Moreover, the participants had undergone training, formal education and continuous support on the PMTCT programme. Three large clinics were selected as the main clusters of the sub-district. Tesch's method was used to analyse the qualitative data.Results Healthcare workers indicated ineffective utilisation of the PMTCT programme services by HIV-positive pregnant women. Most women had challenges with child feeding owing to limited knowledge. Another challenge indicated by healthcare workers was lack of resources. It is important that recommendations be implemented to assist with availability and accessibility of the PMTCT programme.Conclusion Availability and accessibility of PMTCT programme services are still problematic. The study has the potential to inform development of strategies that may facilitate access to care for PMTCT programme clients.This article assesses the history of HIV testing among community-based HIV counselling and testing (CBCT) clients between 2014 and 2018 in 13 South African districts. Consenting clients were tested for HIV and interviewed to categorise as first-time testers or repeat testers. Of the 1 800 753 clients tested for HIV, 15.7% (95% CI [15.6-15.7]) were first-time testers. The rate of identifying first-time testers decreased by 10.7% in four years from 18.4% in year one to 7.7% in year four. A substantial proportion (5.5% [5.4-5.6]) of HIV-positive people not yet on antiretroviral treatment sought HIV re-test, of whom nearly half (48.4% [47.1-49.6]) did not disclose their HIV-positive status during pre-counselling and were re-tested. A decreasing proportion of first-time testers may signal positive progress towards universal HIV testing. This downward trend should be sustained to control the HIV epidemic.Background The interrelationships among the different stages of impaired glucose metabolism, insulin resistance, and hypertension are not fully understood. Methods and Results We investigated the impact of insulin resistance, plasma glucose, and serum immunoreactive insulin levels on hypertension in 19 166 participants with different stages of impaired glucose metabolism (7114 normal fasting glucose/normal glucose tolerance, 3543 isolated impaired fasting glucose [IFG], 2089 isolated impaired glucose tolerance, 2922 IFG plus impaired glucose tolerance, and 3498 diabetes mellitus]) determined by 75-g oral glucose tolerance tests. Participants were recruited from examinees who finished a general health checkup for atomic bomb survivors between 1982 and 2017. The profiles of plasma glucose and immunoreactive insulin during oral glucose tolerance tests were assessed using the total area under the curve. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance. The rate of hyperon only in the early stages of impaired insulin metabolism.Background Renal artery stenosis is a common cause of renal ischemia, contributing to the development of chronic kidney disease. Cell Cycle inhibitor To investigate the role of local CD40 expression in renal artery stenosis, Goldblatt 2-kidney 1-clip surgery was performed on hypertensive Dahl salt-sensitive rats (S rats) and genetically modified S rats in which CD40 function is abolished (Cd40mutant). Methods and Results Four weeks following the 2-kidney 1-clip procedure, Cd40mutant rats demonstrated significantly reduced blood pressure and renal fibrosis in the ischemic kidneys compared with S rat controls. Similarly, disruption of Cd40 resulted in reduced 24-hour urinary protein excretion in Cd40mutant rats versus S rat controls (46.2±1.9 versus 118.4±5.3 mg/24 h; P less then 0.01), as well as protection from oxidative stress, as indicated by increased paraoxonase activity in Cd40mutant rats versus S rat controls (P less then 0.01). Ischemic kidneys from Cd40mutant rats demonstrated a significant decrease in gene expression of the profibrotic mediator, plasminogen activator inhibitor-1 (P less then 0.
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