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NAC treatment or AON overexpression effectively prevented HFD-induced intracellular ROS production and reduction of BM lin- /CD117+ population. These data suggested that long-term HFD selectively decreased BM lin- /CD117+ cell population in aging mice through increased ROS production. © 2020 John Wiley & Sons, Ltd.Early detection surveillance is used for various purposes, including the early detection of non-communicable diseases (e.g., cancer screening), of unusual increases of disease frequency (e.g., influenza or pertussis outbreaks), and the first occurrence of a disease in a previously free population. This latter purpose is particularly important due to the high consequences and cost of delayed detection of a disease moving to a new population. Quantifying the sensitivity of early detection surveillance allows important aspects of the performance of different systems, approaches and authorities to be evaluated, compared and improved. While quantitative evaluation of the sensitivity of other branches of surveillance have been available for many years, development has lagged in the area of early detection, arguably one of the most important purposes of surveillance. This paper, using mostly animal health examples, develops a simple approach to quantifying the sensitivity of early detection surveillance, in terms of population coverage, temporal coverage, and detection sensitivity. SCH58261 purchase This approach is extended to quantify the benefits of risk-based approaches to early detection surveillance. Population-based clinical surveillance (based on either farmers and their veterinarians, or patients and their local health services) provides the best combination of sensitivity, practicality and cost-effectiveness. These systems can be significantly enhanced by lifting disincentives to reporting, for instance by implementing effective strategies to improve farmer awareness and engagement with health services and addressing the challenges of well-intentioned disease notification policies that inadvertently impose barriers to reporting. This article is protected by copyright. All rights reserved.Zero-dimensional (0D) lead-free perovskites have unique structures and optoelectronic properties. Here, we report undoped and Sb-doped all inorganic, lead-free, 0D perovskite single crystals A 2 InCl 5 (H 2 O) (A = Rb, Cs), which exhibit greatly enhanced yellow emission. To study the effect of coordination H 2 O, Sb-doped A 3 InCl 6 (A = Rb, Cs) are also synthesized and further studied. The photoluminescence (PL) color changes from yellow to green emission. Interestingly, the photoluminescence quantum yield (PLQY) realizes a great boost from less then 2% to 85-95% through doping Sb 3+ . We further explore the effect of Sb 3+ dopants and the origin of bright emission by ultrafast transient absorption techniques. In addition, undoped and Sb-doped 0D rubidium indium chloride perovskites show excellent stability. These findings not only provide a way to design a set of new high-performance 0D lead-free perovskites, but also reveal the relationship between structure and PL properties. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Older adults recently discharged from hospital are at high risk of functional decline and falls. A tailored fall prevention education provided at hospital discharge aimed to improve the capacity of older adults to engage in falls prevention activities. What remains unknown are the factors affecting behaviour change after hospital discharge. This study identified the perceived barriers and enablers of older adults to engagement in fall prevention activities during the 6-month period post-discharge. An exploratory approach using interpretative phenomenological analysis focused on the lived experience of a purposive sample (n = 30) of participants. All were recruited as a part of an RCT (n = 390) that delivered a tailored fall prevention education program at three hospital rehabilitation wards in Perth, Australia. Data were collected at 6-month post-discharge using semi-structured telephone surveys. Personal stories confirmed that some older adults have difficulty recovering functional ability after hospital dismissions is required. © 2020 John Wiley & Sons Ltd.Lung ultrasound has recently been suggested by the Chinese Critical Care Ultrasound Study Group and Italian Academy of Thoracic Ultrasound as an accurate tool to detect lung involvement during COVID-19. Although chest Computer Tomography (CT) represents the gold standard to assess lung involvement, with a specificity even superior to the nasal/pharyngeal swab for diagnosis, lung ultrasound examination can be a valid alternative to CT scan, with some advantages, particularly desirable for pregnant women. Indeed, ultrasound can be performed directly at bed side by a single operator, reducing the risk of spreading the outbreak among health professionals, as well as it is a radiation free exam making to be easier monitoring those patients who require serial exams. In the present study, we reported four cases of pregnant women affectd by COVID-19 infection who have been monitoring with lung ultrasound examination. All patients showed ultrasound features indicative of COVID-19 pneumonia at admission irregular pleural lines and vertical artifacts (B-lines) were observed in all four cases, whereas patchy areas of white lung in two cases. LUS was more sensitive than chest X-ray in detecting COVID-19. Three patients had resolution of lung pathology at ultrasound after 96 h of admission. Two pregnancies are ongoing, whereas two patients had cesarean delivery with no fetal complications. PCR testing of both cord blood and newborn swabs were negative in both cases. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.AIM The Sodergren score was developed to objectively measure the severity of haemorrhoidal symptoms. This study aimed to determine if there was a difference in the Sodergren scores between patients who were offered surgery and patients who underwent successful rubber band ligation of internal haemorrhoidal disease and to assess its performance in guiding management. METHOD This is a prospective, observational study. The pre-intervention Sodergren scores of subjects with internal haemorrhoidal disease were recorded and blinded to the surgeon in-charge. Sodergren scores of subjects in the two arms were un-blinded and compared at the end of the study. RESULTS The results of 290 patients were available for final analysis. The median scores of those offered surgery and those who underwent successful rubber band ligation differed significantly [4 (interquartile range 3-10) versus 0 (interquartile range 0-4), P = 0.001]. In predicting treatment, the Sodergren score had an area under the receiver operating characteristic curve of 0.
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