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Purpose The use of technology (e.g., telehealth) in clinical settings has rapidly increased, and its use in research settings continues to grow. The aim of this report is to present one potential solution to a clinical issue that of virtual and remote assessment for the purposes of spoken language research in persons with aphasia (PWA). To do so, we report detailed methods for conducting a multitimepoint (test-retest) virtual paradigm, assessing lifestyle, physiological, cognitive, and linguistic factors in persons with and without aphasia. Method Procedures for virtual assessment are detailed in a sample of adults with no brain damage (N = 24) and PWA (N = 25) on a test-retest paradigm (data collection approximately 10 ± 3 days apart). This report provides practical information about pre-assessment (e.g., recruitment, scheduling), assessment (e.g., aphasia-friendly consent presentation, investigator fidelity), and postassessment (e.g., data storage, quality check) procedures for human behavior research using a virtual platform. Results Preliminary study data are provided, indicating high retention rates, high rates of data acquisition, and feasibility. Common technological troubles and solutions are discussed, and solutions are offered. The results suggest that our pre-assessment, assessment, and postassessment procedures contributed to the success of our study. Conclusions We provide a practical methodology for conducting a multitimepoint study, with considerations for PWA, adding to the body of research on telehealth in clinical populations. Future studies should continue to evaluate telemethodology, which may be core for diversifying studies, improving study retention, and enrolling larger sample sizes. Supplemental Material https//doi.org/10.23641/asha.14608101.Sensitization to a contact allergen brings with it a lifelong risk to develop allergic contact dermatitis. Inflammation is an important part of the skin sensitizing mechanism, and understanding how different haptens stimulate the immune system, as well as the role played by different cell types present in skin, may be helpful for developing optimized in vitro models for risk assessment of new chemicals or mixtures. The aim of this study was to compare the cytokine profile following exposure of cells representing keratinocytes (HaCaT), monocytes (THP-1) and a co-culture of these cells to three clinically important skin sensitizers cobalt (II) chloride (CoCl2), methylisothiazolinone (MI) and p-phenylenediamine (PPD). Secretion of ten pro-inflammatory cytokines was measured using multiplexing. The results showed that the cytokine response differed substantially between the three cell assays. CoCl2 caused an increase of IL-8 in HaCaT cells, while the induction of also IL-13 and IL-1β was observed in THP-1 cells and co-cultures. MI induced six cytokines in HaCaT cells but only IL-1β in the THP-1 cells and four cytokines in the co-culture. Interestingly, the IL-1β response was massive in the co-culture. PPD caused release of IL-1β in all three models as well as IL-8 in the co-culture. Control experiments with two non-sensitizers and irritants (lactic acid and sodium dodecyl sulfate) showed no effect on IL-8 or IL-1β in the co-culture. Taken together, results from this exploratory analysis show unique cytokine profiles dependent on the type of hapten and cell model. Importantly, all three haptens triggered secretion of IL-1β and IL-8 in a co-culture of HaCaT cells and THP-1 cells, representing the most robust test system.Broussonetia papyrifera, Cryptomeria fortunei, Arundo donax, and Robinia pseudoacacia were planted on a zinc smelting slag site. The habitat conditions and spatial distribution of arsenic (As) and antimony (Sb) in slag were analyzed after seven years of restoration. The results showed that the pH, conductivity (EC), and moisture content of phytoremediated slag were lower than those of the control slag. The redox potential (Eh) and EC decreased with increasing slag depth. Phytostabilization significantly increased the contents of total nitrogen (TN), total phosphorus (TP), available nitrogen (AN), available phosphorus (AP), and dissolved organic carbon (DOC) in slag. TN, AN, AP, and DOC in slag showed obvious surface polymerization. Phytostabilization increased the content of calcite and gypsum in the slag. As and Sb concentrations were significantly lower than control slag, with an average decrease of 651-844 and 422-693 mg·kg -1, respectively. Residual As and Sb in phytoremediated slag was the most present fThe results obtained can be used as necessary information for the large-scale ecological restoration or vegetation reconstruction of zinc smelting slag yards.Purpose This study compares online word recognition and prediction in preschoolers with (a suspicion of) a developmental language disorder (DLD) and typically developing (TD) controls. Furthermore, it investigates correlations between these measures and the link between online and off-line language scores in the DLD group. https://www.selleckchem.com/products/au-15330.html Method Using the visual world paradigm, Dutch children ages 3;6 (years;months) with (a suspicion of) DLD (n = 51) and TD peers (n = 31) listened to utterances such as, "Kijk, een hoed!" (Look, a hat!) in a word recognition task, and sentences such as, "Hé, hij leest gewoon een boek" (literal translation Hey, he reads just a book) in a word prediction task, while watching a target and distractor picture. Results Both groups demonstrated a significant word recognition effect that looked similar directly after target onset. However, the DLD group looked longer at the target than the TD group and shifted slower from the distractor to target pictures. Within the DLD group, word recognition was linked to off-line expressive language scores. For word prediction, the DLD group showed a smaller effect and slower shifts from verb onset compared to the TD group. Interestingly, within the DLD group, prediction behavior varied considerably, and was linked to receptive and expressive language scores. Finally, slower shifts in word recognition were related to smaller prediction effects. Conclusions While the groups' word recognition abilities looked similar, and only differed in processing speed and dwell time, the DLD group showed atypical verb-based prediction behavior. This may be due to limitations in their processing capacity and/or their linguistic knowledge, in particular of verb argument structure.
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