Notes

Molybdenum Disulfide-Zinc Oxide Photocathodes with regard to Photo-Rechargeable Zinc-Ion Batteries.
Therefore, a hub RBP-circRNA network was generated based on TARDBP. RNA immunoprecipitation and RNA pull-down confirmed that hsa_circ_0004913 binds to TARDBP. These findings indicated certain RBP-circRNA regulatory network potentially involved in the pathogenesis of HCC, which provides novel insights into the mechanism study and biomarker identification for HCC.Prostate adenocarcinoma is one of the leading adult malignancies. Identification of multiple causative biomarkers is necessary and helpful for determining the occurrence and prognosis of prostate adenocarcinoma. We aimed to identify the potential prognostic genes in the prostate adenocarcinoma microenvironment and to estimate the causal effects simultaneously. We obtained the gene expression data of prostate adenocarcinoma from TCGA project and identified the differentially expressed genes based on immune-stromal components. Among these genes, 68 were associated with biochemical recurrence at 3 years after prostatectomy in prostate adenocarcinoma. After adjusting for the minimal sets of confounding covariates, 14 genes (TNFRSF4, ZAP70, ERMN, CXCL5, SPINK6, SLC6A18, CHRM2, TG, CLLU1OS, POSTN, CTSG, NETO1, CEACAM7, and IGLV3-22) related to the microenvironment were identified as prognostic biomarkers using the targeted maximum likelihood estimation. Both the average and individual causal effects were obtained to measure the magnitude of the effect. CIBERSORT and gene set enrichment analyses showed that these prognostic genes were mainly associated with immune responses. POSTN and NETO1 were correlated with androgen receptor expression, a main driver of prostate adenocarcinoma progression. Finally, five genes were validated in another prostate adenocarcinoma cohort (GEO GSE70770). These findings might lead to the improved prognosis of prostate adenocarcinoma.Methicillin-resistant Staphylococcus aureus (MRSA) constitutes a constant threat for the public health. Aim of the present study was to analyse the whole genome sequences of two MRSA strains belonging to Staphylococcus protein A (spa) type t127 isolated from humans working in two distantly located dairy production farms in Greece.MRSA strains were isolated from the nasal cavity of a food handler in a milk industry in Epirus, northwestern Greece (E-MRSA), and a person working in a cattle farm in Thrace, northeastern Greece (T-MRSA). Whole genome sequences taken using next generation sequencing were analysed for resistance and virulence genes applying various bioinformatic tools.Both isolates were assigned to ST1-IVa-t127 type, and they were transferring genes conferring resistance to tetracycline, β-lactams, and aminoglycosides; T-MRSA was carrying additional genes leading to macrolide, lincosamide and streptogramin B (MLSB) resistance. Both isolates were carrying three plasmid replicon types, rep5, rep7 and rep16, while T-MRSA harboured also rep10 and rep15. E-MRSA carried scn and sak genes which were absent from T-MRSA.In conclusion, the genetic characterization of two unrelated ST1-IVa-t127 MRSA strains isolated from humans in close contact with livestock in Greece can be used as basis for further epidemiological and evolutionary studies.Összefoglaló. NSC 66389 Célkitűzés A már több mint egy évtizede alkalmazott lézeres aranyérműtét technikai tapasztalatai alapján kidolgozott mikrohullámú termo-koagulációs műtét bevezetésének korai eredményeinek bemutatása. Közleményünkben a lézeres és microwave elven működő eszközökkel végzett aranyérműtéti eredményeinket mutatjuk be. Betegek és módszerek A 26 lézerszállal és a 14 mikrohullámú merev antennával végzett műtét összehasonlítását végeztük el. Eredmények Mindkét csoportban az átlagos panaszmentesség 2 hét alatt alakult ki, a két módszer között jelentős különbséget nem találtunk. Megbeszélés Az új műtéti eljárásokat kereső világunkban az általunk most kipróbált lehetőség lehetővé teszi a gyors és teljes gyógyulást adó kezelést. A termo elven működő rendszerek kevesebb fizikai roncsolással érik el a kívánt hatást. A microwave technika a lézeres beavatkozások biztonsági előírásainak szükségessége és körülményessége nélkül alkalmazható.
Abstract In addition to the traditional surgical options for hemorrhoid dity requirements of laser interventions.Összefoglaló. Esetismertetés A gyomor subepitheliális tumorainak laparoszkópos ékresectiója egy széleskörűen elfogadott és alkalmazott eljárás. A gastro-oesophagealis junctio (GOJ) közeli elváltozások esetén ez a technika azonban a gyomorbemenet szűkületének magas kockázata miatt erősen korlátozott. Ilyen lokalizáció esetén megfelelő technika lehet a laparoszkópos transgastricus resectio. Esetünkben egy 44 éves férfi dysphagiájának hátterében azonosított subepitheliális tumor resectióját végeztük el ilyen módon. A műtét során a pneumoperitoneum készítését követően a gyomrot orogastricus szonda segítségével insuffláltuk, majd 3 darab ballonnal rendelkező portot vezettünk a gyomorba. A 6 × 3 × 3 cm-es elváltozás intragastricus kimetszését követően a nyálkahártyát tovafutó öltéssorral zártuk. A speciment zsákba helyeztük, majd a gyomorból és a hasüregből eltávolítottuk. link2 A portok gastrotomiás nyílásait zártuk. 24 órán át nasogastricus szondát hagytunk hátra, hasűri draint nem hagytunk vissza. A pneumoperitoneum ihaving a higher risk for recurrence.
Even though the follow-up of the patient is ongoing, according to the scientific literature, transgastric resection of subepithelial tumors located near the GEJ is a safe and effective technique, which provides good functional results, without having a higher risk for recurrence.Összefoglaló. Bevezetés A neoadjuváns radio-kemoterápia után végzett rektum tumorok műtéte során általános gyakorlattá kezd válni a tehermentesítő ileosztóma képzése a súlyos varratelégtelenségekből származó szövődmények csökkentése érdekében. Maga az ileosztóma is 20-60%-os előfordulási gyakorisággal lehet szövődmények forrása, 16,9-40%-ban pedig a dehidráció képezi a visszavétel okát. Célkitűzés Vizsgálatunk célja az volt, hogy áttekintsük saját beteganyagunkat az ileosztóma szövődményei alapján, különös tekintettel a dehidrációra és az abból fakadó következményekre, ennek segítségével pedig kidolgozzunk egy kezelési protokollt, amely a betegek segítségére van ezen súlyos szövődmények megelőzésében. Eredmények Retrospektív módon elemeztük az osztályunkon 2017. 09. 01. és 2019. 12. 31. között különböző indikáció alapján készített tehermentesítő kacs ileosztóma képzésben részesült betegek morbiditási és mortalitási adatait. link3 Ezen idő alatt 252 rektoszigmoideális reszekciót és 33 abdominoperineális rektum exstihigh risk of readmission caused by ileostomy, it is important to estimate the risk of patients, to educate the inpatients as early as possible, to commence the prevention of dehydration, and regularly monitor in the outpatient setting. Provided the conditions are given, the early closure of ileostomy should be considered.
Trans people face multiple barriers within healthcare. Primary care practitioners are key to trans healthcare but they often lack training in, and understanding of trans identities, and healthcare options. Few studies have examined health professionals' understanding of the barriers that exist in healthcare for trans people.

To map out barriers to providing good quality healthcare to trans and gender diverse people and ways to address them.

A qualitative interview study involving 20 health professionals working with trans and gender diverse people.

Participants were recruited through purposive and snowball sampling. Data were generated using semi-structured qualitative interviews. A thematic analysis involved coding and categorising data using Nvivo software and further conceptual analysis in which developing themes were identified.

The study identified four barrier domains to good quality care for trans and gender diverse people structural (related to lack of guidelines, long waiting times, shortage of specialist centres), educational (based on lack of training on trans health), cultural and social (reflecting negative attitudes towards trans people) and technical (related to information systems and technology).

There is an urgent need to address the barriers trans and gender diverse people face in healthcare. Structural level solutions include health policy, professional education and standards; at the practice level, GPs can act as potential drivers of change in addressing the cultural and technical barriers to better meet the needs of their trans and gender diverse patients.
There is an urgent need to address the barriers trans and gender diverse people face in healthcare. Structural level solutions include health policy, professional education and standards; at the practice level, GPs can act as potential drivers of change in addressing the cultural and technical barriers to better meet the needs of their trans and gender diverse patients.
There is no published algorithm predicting asthma crisis events (Accident and Emergency (A&E) attendance, hospitalisation or death) using routinely available electronic health record (EHR) data.

To develop an algorithm to identify individuals at high risk of an asthma crisis event.

Database analysis from primary care EHRs.

Multivariable logistic regression was applied to a dataset of 61,861 people with asthma from England and Scotland using the Clinical Practice Research Datalink. External validation was performed using the Secure Anonymised Information Linkage databank of 174,240 patients from Wales. Outcomes were one or more hospitalisation (development dataset) and asthma-related hospitalisation, A&E attendance or death (validation dataset) within a 12-month period.

Risk factors for asthma-related crisis events included previous hospitalisation, older age, underweight, smoking and blood eosinophilia. The prediction algorithm had acceptable predictive ability with a Receiver Operating Characteristic (ROC) of 0.71 (0.70, 0.72) in the validation dataset. Using a cut-point based on the 7% of the population at greatest risk results in a positive predictive value of 5.7% (95% CI 5.3 - 6.1) and a negative predictive value of 98.9% (98.9 - 99.0), with sensitivity of 28.5% (26.7 - 30.3) and specificity of 93.3% (93.2 - 93.4); they had an event risk of 6.0% compared 1.1% for the remaining population. Eighteen people would be "needed to follow" to identify one admission.

This externally validated algorithm has acceptable predictive ability for identifying patients at high risk of asthma-related crisis events and excluding individuals not at high risk.
This externally validated algorithm has acceptable predictive ability for identifying patients at high risk of asthma-related crisis events and excluding individuals not at high risk.
With improved accessibility to social media globally, health researchers are capitalizing on social media platforms to recruit participants for research studies. This has particularly been the case during the COVID-19 pandemic, when researchers were not able to use traditional methods of recruitment. Nevertheless, there is limited evidence on the feasibility of social media for recruiting a national sample.

This paper describes the use of social media as a tool for recruiting a national sample of adults to a web-based survey during the COVID-19 pandemic.

Between August and October 2020, participants were recruited through Facebook via two advertisement campaigns (paid option and no-cost option) into a web-based survey exploring the relationship between social determinants of health and well-being of adults during the COVID-19 pandemic. Data were analyzed using SPSS software and Facebook metrics that were autogenerated by Facebook Ads Manager. Poststratification weights were calculated to match the Australian population on the basis of gender, age, and state or territory based on the 2016 Australian census data.
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