Notes

Introduction with the Efficient Photon Attention Varied for Checking Procedure regarding Crystal Crimson Photodegradation.
15 ± 2.47 pg/ml).A decrease in serum gastrin levels in patients with HP-associated CG and DM type 2 leads to an improvement in the clinical course of the diseases, namely a decrease in nausea, diarrhea, abdominal pain, and discomfort incidence.
Conclusions Patients with DM type 2 and CG associated with HP should include yeast SB to standard AHT as they reduce side effects from this treatment (by an average of 20%), increase the eradication frequency (by 10%), and also lead to significant decrease in serum gastrin (up to 82.15 ± 2.47 pg/ml).A decrease in serum gastrin levels in patients with HP-associated CG and DM type 2 leads to an improvement in the clinical course of the diseases, namely a decrease in nausea, diarrhea, abdominal pain, and discomfort incidence.
The aim Of the work is to investigate and prove the effectiveness of medicinal products of plant origin for the treatment of cardiovascular diseases.

Materials and methods Pharmacoeconomic, social, medical demographic and statistical studies were studied. The study involved cardiologists, pharmacists, consumers of pharmacies and patients of cardiology departments.

Results Forecasting the need for cardiac medicines in general, and in medicinal products of plant origin (MP PO), in particular, is increasing as the population, life expectancy, under the influence of socio-demographic factors, and, most importantly, the increase in the number of elderly people. When solving problems facing public health in the field of drug provision of the population, a regular analysis of the pharmaceutical market and a forecast of the need for medicines in the context of the pharmacotherapeutic group that is being studied are necessary. An important stage in the choice of forecasting methods is the possibility of attracting the required number of indicators, which is a characteristic of the normative method, whose accessibility and simplicity make it possible to use it by specialists who do not have special mathematical training at the level of medical and pharmaceutical organizations.

Conclusions Prevention of diseases should be based on the implementation of government programs for prevention and promotion of health. This will improve and actively use methods of early detection of social and economic factors, which is a threat of development of diseases of the cardiovascular system.
Conclusions Prevention of diseases should be based on the implementation of government programs for prevention and promotion of health. This will improve and actively use methods of early detection of social and economic factors, which is a threat of development of diseases of the cardiovascular system.
The aim To determine the effect of prolonged use of H2-histamine receptor blockers on the degree of contamination of the gastric mucosa with HP infection in patients with chronic non-atrophic gastritis.

Materials and methods 28 patients with chronic atrophic gastritis (the main group), who regularly took H2-histamine receptor blockers for 2 to 7 years, and 30 patients (control group), who never used them were comprehensively examined. Comprehensive examination included step-by-step intragastric pH-metry, esophagogastroduodenoscopy, helicobacter infection test (НР) (helicobacter urease test and microscopic examination of stained smears), histological investigations of the gastric stump mucous, material for which was taken during endoscopy from 4 topographical zones from the middle third of the gastric antrum and body of stomach on the big and small curvature.

Results All the patients in 100% of cases have confirmed the existence of chronic non-atrophic gastritis in both active and inactive stages of vary, with blockers of Н2-histamine receptors.
The aim is to evaluate the effects of L-arginine and L-ornithine on the processes of lipid peroxidation in homogenates of renal cortex, renal medulla and renal papilla under conditions of acute toxic hepatitis.

Materials and methods The study was performed on 40 outbred white male rats with experimental hepatitis, caused by carbon tetrachloride. The animals were divided into five groups control group (the rats were simulated carbon tetrachloride poisoning and its correction by administering of olive oil and normal saline in equivalent doses), acute carbon tetrachloride hepatitis (single intraperitoneal injection of 50% carbon tetrachloride oil solution at the dose of 2 mlxkg-1 of body weight and simulation of treatment by administration of normal saline in equivalent doses), acute carbon tetrachloride hepatitis + L-ornithine (1000 mgxkg-1), acute carbon tetrachloride hepatitis + L-arginine (500 mgxkg-1) and acute carbon tetrachloride hepatitis + combination of substances.

Results On the background of acich are the most important requirements for modern drugs for the treatment of hepato-renal syndrome.
The aim To study the effectiveness of using medicine meldonium in standard therapy to the correction of prooxidant-antioxidant and kallikrein-kinin disorders in patients with chronic pancreatitis andstable coronary artery disease.

Materials and methods The study included 90 patients with chronic pancreatitis andstable coronary artery disease.They were divided into two groups I group (45 patients) received standard treatment; II group (45 patients) along with basic therapy received medication meldonium (Vazonat) for 2 capsules (500 mg) once daily for two months. Indicators prooxidant-antioxidant system in blood plasma was determined by biochemical method, indicators of kallikrein-kinin system- by chromatographic method.

Results The better status of the prooxidant-antioxidant system and kallikrein-kinin system was observed in patients who received in addition to standard protocol treatment with meldonium.

Conclusions Adding to the complex therapy of patients with chronic pancreatitis and stable coronary artery disease of the medicine meldonium helps to improve the prooxidation-antioxidant status and disorders in the kallikrein-kinin system more significantly compared with standard basic therapy.
Conclusions Adding to the complex therapy of patients with chronic pancreatitis and stable coronary artery disease of the medicine meldonium helps to improve the prooxidation-antioxidant status and disorders in the kallikrein-kinin system more significantly compared with standard basic therapy.
The aim To identify the significance of biomarkers characterizing the role of lipid disorders and the processes of destruction atherosclerotic plaque for the early diagnosis of CHD in patients with COPD.

Materials and methods There were examined 153 patients, men aged 40-70 years, including 53 patients with COPD, 56 with a combination of COPD and CHD and 44 patients with stable CHD. The level of LP (a) and PAPP-A in the serum was determined by ELISA.

Results There was increased level of LP (a) and PAPP-A in patients with CHD and with a combination of COPD and CHD. This increased level of LP (a) and PAPP-A was associated with the level of C-reactive protein. The mid level of LP (a) and PAPP-A in patients with COPD did not significantly differ from the reference values.

Conclusions The increase level of lipoprotein (a) more than 18 mg/dl in patients with COPD may be regarded as a predictor of the development of CHD. The level PAPP-A more than 5 mIU/L in plasma of patients with COPD makes it possible to isolate the groups for CHD risk. The definition of LP (a) and PAPP-A in patients with COPD may contribute to the early diagnostics of coronary heart disease in the absence of its pronounced clinical manifestations.
Conclusions The increase level of lipoprotein (a) more than 18 mg/dl in patients with COPD may be regarded as a predictor of the development of CHD. The level PAPP-A more than 5 mIU/L in plasma of patients with COPD makes it possible to isolate the groups for CHD risk. The definition of LP (a) and PAPP-A in patients with COPD may contribute to the early diagnostics of coronary heart disease in the absence of its pronounced clinical manifestations.
The aim To conduct a marketing audit of the pharmaceutical market of Ukraine for acne and demodicosis medications.

Materials and methods The study used marketing methods of analysis, survey, observation methods and reference literature - State Register of Medicines of Ukraine of the State Expert Center of the Ministry of Health of Ukraine.

Results As a result of marketing audit of retail audit data of pharmacy sales revealed that the leading sales in packaging is MNL benzylbenzoate, the share of which reached in different years from 45% to 32%, which was 1380902 and 647576 packages per year, respectively, in second place - metronidazole , benzoyl peroxide, zinc ointment and sulfur ointment respectively.

Conclusions According to our analysis, it has been found that the highest sales volume (in packs) are of the low-cost brands, which are the most economically available and have the most effective therapeutic effect. Therefore, it is important to create multicomponent soft drugs in the form of cream and gel based on metronidazole, benzyl benzoate and benzoyl peroxide.
Conclusions According to our analysis, it has been found that the highest sales volume (in packs) are of the low-cost brands, which are the most economically available and have the most effective therapeutic effect. Therefore, it is important to create multicomponent soft drugs in the form of cream and gel based on metronidazole, benzyl benzoate and benzoyl peroxide.
The aim Of our work was to study the level of proinflammatory cytokines in patients with diabetic arthropathy and to investigate their possible effect on the development of this complication.

Materials and methods 118 patients were examined, which were divided into groups by type of diabetes, the presence and severity of diabetic arthropathy. The content of IL-1, TNF-α, IL-6 and receptors to S IL-6-R in serum was determined by immunoassay.

Results In patients with diabetic arthropathy, levels of TNF-α (with type 1 diabetes 44.5%, type 2 diabetes 42.9%) and IL-6 (with type 1 diabetes 52.1%, with diabetes 2 types by 64.4%) significantly increased. There is a direct correlation between the severity of joint damage and the level of TNF-α and IL-6. N6-methyladenosine For IL -1, receptors for S IL-6-R have not been detected.

Conclusions The chances of detecting arthropathy with type 1 diabetes with increasing TNF levels increase by 1.7 times, with an increase in IL-6 by 1.5 times. For type 2 diabetes, it is 1.8 and 1.3 times, respectively. Thus, TNF-α and IL-6 may be markers of the presence and progression of arthropathy in patients with diabetes mellitus.
Conclusions The chances of detecting arthropathy with type 1 diabetes with increasing TNF levels increase by 1.7 times, with an increase in IL-6 by 1.5 times. For type 2 diabetes, it is 1.8 and 1.3 times, respectively. Thus, TNF-α and IL-6 may be markers of the presence and progression of arthropathy in patients with diabetes mellitus.
The aim With the help of biochemical and morphological methods of investigation to identify the causes of a false postoperative recurrence of varicose veins after the EVLC.

Materials and methods In 173 patients with varicose veins of the lower extremities, the level of markers of endothelial dysfunction was determined P-selectin, E-selectin, tissue plasminogen activator, endothelin-1, adhesion molecules of type 1 vascular endothelium (sVCAM-1-soluble vascularcellularmolecula), circulating endothelial cells (CEC) before surgery (EVLC), on the 10th and 60th day of the postoperative period.At the same time, a morphological and electron microscopic examination of the state of the deep venous system in 31 patients with varicose vein disease of the lower extremities who died from acute heart failure, was performed.

Results Increased values of markers of endothelial dysfunction in patients with varicose veins of the lower extremitiesbefore surgery of EVLC were established. We found that, despite the operation, the parameters of endothelial dysfunction decrease, but in the remote postoperative period do not come to the norm.
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