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Development of cytokine manufacturing capability throughout old as well as contemporary Western european communities.
g arthroscopic surgery, knotless anchors could be used safely for the fixation of the meniscal root ligament.OBJECTIVE The aim of this study was to assess the clinical and radiological results of our high tibial osteotomy technique combining fixator-assisted nailing and subtubercle tibial osteotomy in varus malalignment. METHODS This was a retrospective study of a consecutive series of 32 knees in 32 patients ('2 follow-up loss' 12 males and 18 females; mean age at the time of operation 50.6±7.8 (36-62) years) operated on between 2014 and 2016. CB1954 nmr Radiographic and clinical measurements were assessed pre- and postoperatively. Kolmogorov-Smirnov, paired t and Wilcoxon rank tests were used in the statistical analyses. RESULTS The mean follow-up period was 36.1±8.15 (31-53) months, the mean duration of the hospital stay was 3.6±0.1 (2-6) days, and the mean Kellgren-Lawrence score was 2.4±0.6 (2-4). Time to bony union was an average of 16.17 (12-29) weeks. Compared to the preoperative mechanical medial proximal tibial angle, femorotibial angle and mechanical axis deviation measurements, all the postoperative values showed significant changes (p0.05). The postoperative visual analog scale, Knee Society Score, and Modified Hospital for Special Surgery Knee Scoring System measures showed significant improvement compared to the preoperative values (p less then 0.01). The postoperative walking distance increased to 1137.50±845.1 meters, from 359.4±306.2 meters (p less then 0.01). CONCLUSION This percutaneous technique is minimally invasive, corrects the alignment in two planes, and does not affect patellar height. We believe that this technique could be a promising alternative to other knee preserving surgeries in correcting varus malalignment. LEVEL OF EVIDENCE Level IV, Therapeutic Study.OBJECTIVE The aim of this prospective randomized trial was to compare cemented (CHA) and uncemented bipolar hemiarthroplasty (UCH) in patients with femoral neck fractures (FNF). METHODS The study included 158 patients aged ≥76 years who underwent bipolar HA for displaced FNF. Patients were randomized in two groups the cemented group (CHA, n=79) was treated with cement and the uncemented group (UCH, n=79) without cement. The groups were compared for operating time, blood loss and peroperative morbidity and mortality rates. RESULTS Both the CHA and the UCH group did not differ significantly in terms of age (86±5 vs. 84±4 years), sex (58.3% male vs. 60.7% female), and comorbidities (p=0.49). The CHA group had a significantly longer operating time (p=0.038) and a greater intraoperative blood loss (p=0.024). In the CHA group there were 8 (10.1%) events of intraoperative drop in the oxygen saturation (SaO2), whereas no such events were noted in the UCH group (p=0.009). Despite no significant difference between thesvel II, Randomized Controlled Trial.OBJECTIVE This study aimed to evaluate whether a history of a pelvic osteotomy or proximal femoral osteotomy compromises the outcomes of total hip arthroplasty in patients with dysplastic coxarthrosis. METHODS The results of total hip arthroplasty in 240 hips of 172 patients without previous pelvic osteotomy or proximal femoral osteotomy were compared to 118 hips of 88 patients with a previous pelvic osteotomy or proximal femoral osteotomy (osteotomy group). Technical difficulties and rates of complications during surgery, operative time, estimated blood loss, rates of postoperative complications, and pre- and postoperative Harris Hip Scores and visual analog scale pain scores were compared between the two groups. RESULTS In the osteotomy, the rate of complications was higher and the operative time was longer. The estimated blood loss was also higher, and the latest follow-up Harris Hip Scores and visual analog scale pain scores were worse in this group. Total hip arthroplasty was more demanding and the revision rate was higher in the osteotomy group (six vs four revisions). CONCLUSION Our data showed that a previous history of pelvic osteotomy or proximal femoral osteotomy compromised the clinical outcomes of subsequent total hip arthroplasty and is related to an increased rate of complications, prolonged operative time, and increased amount of blood loss. LEVEL OF EVIDENCE Level III, Therapeutic Study.OBJECTIVE The aim of this study was compare the clinical success of treatments for avascular necrosis and osteochondritis dissecans in cases who underwent matrix autologous chondrocyte implantations, and evaluate cartilage thickness on the clinical outcomes after implantation. METHODS A total of 37 patients (29 men, and 8 women; mean age 23.8 years (16-38)) were treated prospectively with a two-stage matrix autologous chondrocyte implantation (avascular necrosis, n=21; osteochondritis dissecans, n=18). Clinical improvements and follows-up were assessed based on the patients' International Cartilage Repair Society (ICRS) scores with simultaneous cartilage thickness measurement using short-TI inversion recovery magnetic resonance imaging. The patients were divided into four subgroups based on their clinical scores, as group D less then 65 points, Group C 65-83 points, Group B 84-90 and Group A ≥90. RESULTS The mean ICRS score was 28.33±7.14 in the preoperative period in the avascular necrosis group, which increased to 70.88±12.61 at 60 months; while the mean ICRS score increased from 29.75±7.15 preoperatively to 87.58±12.83 at 60 months in the osteochondritis dissecans group. A statistically significant difference in the ICRS scores was noted between the two groups, and also between the ICRS scores and cartilage thicknesses of the subgroups (p less then 0.05). CONCLUSION Our study results revealed that greater clinical improvement was achieved in patients with osteochondritis dissecans undergoing matrix autologous chondrocyte implantation than in those with avascular necrosis. In addition, cartilage thickness greater than 3.7 mm following an autologous chondrocyte transplantation showed excellent clinical improvement. LEVEL OF EVIDENCE Level III, Therapeutic Study.OBJECTIVE The aim of this study was to investigate the immunohistochemical stain profiling of adipocytic tumors. METHODS From our archive files between the years of 2012-2018, excised, formalin-fixed and paraffin-embedded adipocytic tumors were retrospectively screened and 61 subjects were selected. The gender, age, tumor location and tumor diameter were evaluated. The cases were investigated in terms of p16, CD34, MDM2 expression and clinicopathological information. RESULTS Of the 61 patients included in the study, we found that 2 had hibernoma, 4 had lipoblastoma, 14 had spindle cell lipoma (SCL), 10 had lipoma, 20 had atypical lipomatous tumor/well differentiated liposarcoma (ALT/WDL), and 11 had dedifferentiated liposarcoma (DDL). In terms of diameter, ALT/WDL and DDL were significantly different from the others (p=0.001, p=0.001, respectively). There was a significant difference between the groups according to the location (p=0.001). 35% (7/20) of ALT/WDLs were in the lower extremities (thighs) and 35% (7/20) were located in the retroperitoneal region.
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